Electrophoretic deposition of spray-dried Sr-containing mesoporous bioactive glass spheres on glass–ceramic scaffolds for bone tissue regeneration
Source abstract
Abstract
The development of strong and bioactive scaffolds with a trabecular architecture mimicking that of cancellous bone is one of the major and still partially unmet challenges of modern biomaterials science and regenerative medicine. In this work, we exploited the electrophoretic process to deposit highly bioactive particles of mesoporous glass on the struts of a mechanically strong but almost inert glass–ceramic scaffold produced by the sponge replica method. A SiO2–CaO–SrO mesoporous glass was innovatively synthesized by aerosol-assisted spray drying in order to obtain spherical particles with high control over shape and morphology. The glass microspheres underwent morphological, chemical and textural characterizations, and the release kinetics of strontium—known for its ability to stimulate new bone formation in osteoporotic bone—were assessed upon immersion in simulated body fluid. Sr-containing mesoporous glass particles electrophoretically deposited on the scaffold walls retained a fast apatite-forming ability and formed a highly bioactive coating on the macroporous substrate without occluding the pores. The meso-macroporous hierarchical constructs produced in this research could be proposed as bioactive and mechanically strong implants for potential applications in bone tissue engineering.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Layered Double Hydroxides Synthesis and Applications · Advanced Photocatalysis Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
Show source-provided references
1. Hench LL (2006) The story of Bioglass®. J Mater Sci Mater Med 17:967–978. doi: 10.1007/s10856-006-0432-z10.1007/s10856-006-0432-z ↗
2. Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB, Bonewald LF, Tomsia AP (2011) Bioactive glass in tissue engineering. Acta Biomater 7:2355–2373. doi: 10.1016/j.actbio.2011.03.01610.1016/j.actbio.2011.03.016 ↗
3. Baino F, Fiorilli S, Vitale-Brovarone C (2016) Bioactive glass-based materials with hierarchical porosity for medical applications: review of recent advances. Acta Biomater 42:18–32. doi: 10.1016/j.actbio.2016.06.03310.1016/j.actbio.2016.06.033 ↗
4. Izquierdo-Barba I, Vallet-Regi M (2015) Mesoporous bioactive glasses: relevance of their porous structure compared to that of classical bioglasses. Biomed Glasses 1:140–150. doi: 10.1515/bglass-2015-001410.1515/bglass-2015-0014 ↗
5. Vallet-Regi M (2009) Nanostructured mesoporous silica matrices in nanomedicine. J Intern Med 267:22–43. doi: 10.1111/j.1365-2796.2009.02190.x10.1111/j.1365-2796.2009.02190.x ↗
6. Wu C, Chang J (2012) Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application. Interface Focus 2:292–306. doi: 10.1098/rsfs.2011.012110.1098/rsfs.2011.0121 ↗
7. Hong Y, Chen X, Zhang X (2010) Preparation, bioactivity, and drug release of hierarchical nanoporous bioactive glass ultrathin fibers. Adv Mater 22:754–758. doi: 10.1002/adma.20090165610.1002/adma.200901656 ↗
8. Zhu Y, Wu C (2007) Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering. Microporous Mesoporous Mater 112:494–503. doi: 10.1016/j.micromeso.2007.10.02910.1016/j.micromeso.2007.10.029 ↗
9. Ostomel TA, Shi Q, Tsung CK (2006) Spherical bioactive glass with enhanced rates of hydroxyapatite deposition and hemostatic activity. Small 11:1261–1265. doi: 10.1002/smll.20060017710.1002/smll.200600177 ↗
10. Vichery C, Nedelec JM (2016) Bioactive glass nanoparticles: from synthesis to materials design for biomedical applications. Materials 9:288–304. doi: 10.3390/ma904028810.3390/ma9040288 ↗
11. Arcos D, Lopez-Noriega A, Vallet-Regi M (2009) Ordered mesoporous microspheres for bone grafting and drug delivery. Chem Mater 21:1000–1009. doi: 10.1021/cm801649z10.1021/cm801649z ↗
12. Fiorilli S, Pontiroli L, Vitale-Brovarone C (2013) Spray-dried mesoporous silica spheres functionalized with carboxylic groups. Mater Lett 108:118–121. doi: 10.1016/j.matlet.2013.06.04010.1016/j.matlet.2013.06.040 ↗
13. Pontiroli L, Dadkhah M, Novajra G, Tcacencu I, Fiorilli S, Vitale-Brovarone C (2016) An aerosol-spray-assisted approach to produce mesoporous bioactive glass microspheres under mild acidic aqueous conditions. Mater Lett 190:111–114. doi: 10.1016/j.matlet.2016.12.12510.1016/j.matlet.2016.12.125 ↗
14. Habibovic P, Barralet JE (2011) Bioinorganics and biomaterials: bone repair. Acta Biomater 7:3013–3026. doi: 10.1016/j.actbio.2011.03.02710.1016/j.actbio.2011.03.027 ↗
15. Jones J (2013) Review of bioactive glass: from Hench to hybrids. Acta Biomater 9:4457–4486. doi: 10.1016/j.actbio.2012.08.02310.1016/j.actbio.2012.08.023 ↗
16. Baino F, Caddeo S, Novajra G, Vitale-Brovarone C (2016) Using porous bioceramic scaffolds to mimic healthy and osteoporotic bone. J Eur Ceram Soc 36:2175–2182. doi: 10.1016/j.jeurceramsoc.2016.01.01110.1016/j.jeurceramsoc.2016.01.011 ↗
17. Baino F, Vitale-Brovarone C (2014) Mechanical properties and reliability of glass-ceramic foam scaffolds for bone repair. Mater Lett 118:27–30. doi: 10.1016/j.matlet.2013.12.03710.1016/j.matlet.2013.12.037 ↗
18. Vitale-Brovarone C, Baino F, Tallia F, Gervasio C, Verné E (2012) Bioactive glass-derived trabecular coating: a smart solution for enhancing osteointegration of prosthetic elements. J Mater Sci Mater Med 23:2369–2380. doi: 10.1007/s10856-012-4643-110.1007/s10856-012-4643-1 ↗
19. Laxmidhar B, Meilin L (2006) A review on fundamentals and applications of electrophoretic deposition (EPD). Prog Mater Sci 52:1–61. doi: 10.1016/j.pmatsci.2006.07.00110.1016/j.pmatsci.2006.07.001 ↗
20. Boccaccini AR, Keim S, Ma R, Li Y, Zhitomirsky I (2010) Electrophoretic deposition of biomaterials. J R Soc Interface 7:S581–S613. doi: 10.1098/rsif.2010.0156.focus10.1098/rsif.2010.0156.focus ↗
21. Chen Q, Cordero-Arias L et al (2013) Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition. Surf Coat Technol 233:49–56. doi: 10.1016/j.surfcoat.2013.01.04210.1016/j.surfcoat.2013.01.042 ↗
22. Chen Q, Cabanas-Polo S et al (2014) Electrophoretic co-deposition of polyvinyl alcohol (PVA) reinforced alginate—Bioglass® composite coating on stainless steel: mechanical properties and in vitro bioactivity assessment. Mater Sci Eng C 40:55–64. doi: 10.1016/j.msec.2014.03.01910.1016/j.msec.2014.03.019 ↗
23. Chen Q, Garcia RP et al (2015) Cellulose nanocrystals—bioactive glass hybrid coating as bone substitutes by electrophoretic co-deposition. In situ control of mineralization of bioactive glass and enhancement of osteoblastic performance. ACS Appl Mater Interfaces 7:24715–24725. doi: 10.1021/acsami.5b0729410.1021/acsami.5b07294 ↗
24. Fiorilli S, Baino F, Vitale-Brovarone C (2015) Electrophoretic deposition of mesoporous bioactive glass on glass–ceramic foam scaffolds for bone tissue engineering. J Mater Sci Mater Med 26:1–12. doi: 10.1007/s10856-014-5346-610.1007/s10856-014-5346-6 ↗
25. Ma H, Baino F, Fiorilli S, Vitale Brovarone C (2013) Al-MCM-41 inside a glass–ceramic scaffold: a meso–macroporous system for acid catalysis. J Eur Ceram Soc 33:1535–1543. doi: 10.1016/j.jeurceramsoc.2013.01.00410.1016/j.jeurceramsoc.2013.01.004 ↗
26. Mehdipour M, Afshar A, Mohebali M (2012) Electrophoretic deposition of bioactive glass coating on 316L stainless steel and electrochemical behaviour study. Appl Surf Sci 258:9832–9839. doi: 10.1016/j.apsusc.2012.06.03810.1016/j.apsusc.2012.06.038 ↗
27. Xiu FX, Rong FL (2006) Effect of suspension stability on electrophoretic deposition of hydroxyapatite coatings. Mater Lett 60:2627–2632. doi: 10.1016/j.matlet.2006.01.04810.1016/j.matlet.2006.01.048 ↗
28. Boccaccini AR et al (2007) Carbon nanotube coatings on Bioglass-based tissue engineering scaffolds. Adv Funct Mater 17:2815–2822. doi: 10.1002/adfm.20060088710.1002/adfm.200600887 ↗
29. Landers L, Gor GY, Neimark AV (2013) Density functional theory methods for characterization of porous materials. Colloids Surf A 437:3–32. doi: 10.1016/j.colsurfa.2013.01.00710.1016/j.colsurfa.2013.01.007 ↗
30. Kokubo T, Takadama H (2006) How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27:2907–2915. doi: 10.1016/j.biomaterials.2006.01.01710.1016/j.biomaterials.2006.01.017 ↗
31. Fredholm YC, Karpukhina N, Law RV, Hill RG (2010) Strontium containing bioactive glasses: glass structure and physical properties. J Non Cryst Solids 356:2546–2551. doi: 10.1016/j.jnoncrysol.2010.06.07810.1016/j.jnoncrysol.2010.06.078 ↗
32. Thommes M, Kaneko K, Neimark AV (2015) Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC technical report). Pure Appl Chem 87:1051–1069. doi: 10.1515/pac-2014-111710.1515/pac-2014-1117 ↗
33. Midha S, Kim TB, Van Den Bergh W, Lee PD, Jones JR, Mitchell CA (2013) Preconditioned 70S30C bioactive glass foams promote osteogenesis in vivo. Acta Biomater 9:9169–918210.1016/j.actbio.2013.07.014 ↗
34. Lopez-Noriega A, Arcos D, Vallet-Regi M (2006) Ordered mesoporous bioactive glasses for bone tissue regeneration. Chem Mater 18:3137–3144. doi: 10.1021/cm060488o10.1021/cm060488o ↗
35. Gentleman E, Fredholm YC, Jell G, Lotfibakhshaiesh N, O’Donnell MD, Hill RG, Stevens MM (2010) The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. Biomaterials 31:3949–3956. doi: 10.1016/j.biomaterials.2010.01.12110.1016/j.biomaterials.2010.01.121 ↗
36. Zhu Y, Zhu M, He X (2013) Substitutions of strontium in mesoporous calcium silicate and their physicochemical and biological properties. Acta Biomater 9:6723–6731. doi: 10.1016/j.actbio.2013.01.02110.1016/j.actbio.2013.01.021 ↗
37. Wang J et al (2015) Effect of cetyltrimethylammonium bromide on morphology and porous structure of mesoporous hydroxyapatite. Trans Nonferrous Met Soc China 25:483–489. doi: 10.1016/S1003-6326(15)63628-710.1016/S1003-6326(15)63628-7 ↗
38. Kaysinger KK, Ramp WK (1998) Extracellular pH modulates the activity of cultured human osteoblasts. J Cell Biochem 68:83–89. doi: 10.1002/(SICI)1097-4644(19980101)68:110.1002/(SICI)1097-4644(19980101)68:1 ↗
39. Doostmohammadi A et al (2011) Bioactive glass nanoparticles with negative zeta potential. Ceram Int 37:2311–2316. doi: 10.1016/j.ceramint.2011.03.02610.1016/j.ceramint.2011.03.026 ↗
40. Gerhardt LC, Boccaccini AR (2010) Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials 3:3867–3910. doi: 10.3390/ma307386710.3390/ma3073867 ↗
41. Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26:5474–5491. doi: 10.1016/j.biomaterials.2005.02.00210.1016/j.biomaterials.2005.02.002 ↗
42. Kabel J, Odgaard A, Van Rietbergen B, Huiskes R (1999) Connectivity and the elastic properties of cancellous bone. Bone 24:115–12010.1016/S8756-3282(98)00164-1 ↗