Mesoporous titanium dioxide@ zinc oxide–graphene oxide nanocarriers for colon-specific drug delivery
Source abstract
Abstract
In this project, TiO2@ZnO nanoparticles core–shell nanostructured and titanium dioxide@ mesoporous zinc oxide–graphene oxide (TiO2@ZnO–GO) hybrid nanocomposites as controlled targeted drug delivery systems were synthesized by a facile sono-chemical method. We prepared a novel mesoporous and core–shell structure as a drug nanocarrier (NCs) for the loading and pH-responsive characteristics of the chemotherapeutic curcumin. The structure, surface charge, and surface morphology of NCs were studied using with X-ray diffraction, Fourier transform infrared spectroscopy, dynamic light scattering, brunauer–emmett–teller, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The SEM and TEM images of NCs show the uniform hexagonal mesoporous morphology with average grain size of about ∼ 190 nm. The drug loading was very high about 16 and 19 for TiO2@ZnO and TiO2@ZnO–GO, respectively. The NCs showed pH-dependent drug release behavior. Drug release from TiO2@ZnO–GO in neutral pH were higher than in acidic medium, due to anionic charge of GO nanosheet. MTT assay results showed that the curcumin-loaded NCs showed significant toxicity due to which cell viability reduced to below 50% at 140 μg/mL concentration, thereby confirming its anticancer effects. The goal of this study is the application of water-dispersed TiO2@ZnO–GO with pH-dependent release properties for design a new drug delivery carrier.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery · Graphene research and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
Show source-provided references
1. Yancik R, Ries LA (2000) Aging and cancer in America: demographic and epidemiologic perspectives. Hematol Oncol Clin North Am 14(1):17–2310.1016/S0889-8588(05)70275-6 ↗
2. Schlüter K et al (2006) Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potential. Am J Pathol 169(3):1064–107310.2353/ajpath.2006.050566 ↗
3. Ko F-C et al (1999) Risk and patterns of brain metastases in colorectal cancer. Dis Colon Rectum 42(11):1467–147110.1007/BF02235049 ↗
4. Tournigand C et al (2012) Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial. J Clin Oncol 30:3353–336010.1200/JCO.2012.42.5645 ↗
5. Danafar H et al (2017) Co-delivery of hydrophilic and hydrophobic drugs by micelles: a new approach using drug conjugated PEG–PCLNanoparticles. Drug Dev Ind Pharm 43(11):1908–191810.1080/03639045.2017.1355922 ↗
6. Danafar H et al (2017) Investigation of drug delivery of rattle-structured gold nanorod-mesoporous silica nanoparticles core–shell as curcumin carrier and their effect on MCF7 and 4T1 cell lines. J Zanjan Univ Med Sci Health Serv 25(113):124–136
7. Kheiri Manjili H et al (2017) Pharmacokinetics and in vivo delivery of curcumin by copolymeric mPEG-PCL micelles. Eur J Pharm Biopharm 116:17–3010.1016/j.ejpb.2016.10.003 ↗
8. Danafar H (2017) Study of the composition of polycaprolactone/poly (ethylene glycol)/polycaprolactone copolymer and drug-to-polymer ratio on drug loading efficiency of curcumin to nanoparticles. Jundishapur J Nat Pharm Prod 12(1):e34179
9. Sun Y-M et al (2002) Theoretical elucidation on the antioxidant mechanism of curcumin: a DFT study. Org Lett 4(17):2909–291110.1021/ol0262789 ↗
10. Panchatcharam M et al (2006) Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem 290(1–2):87–9610.1007/s11010-006-9170-2 ↗
11. Sun A et al (2006) Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system. J Med Chem 49(11):3153–315810.1021/jm051141k ↗
12. Tønnesen HH, Karlsen J, van Henegouwen GB (1986) Studies on curcumin and curcuminoids VIII. Photochemical stability of curcumin. Z Lebensm Unters Forsch 183(2):116–12210.1007/BF01041928 ↗
13. Tu H et al (2010) Study of the sigmoidal swelling kinetics of carboxymethylchitosan-g-poly (acrylic acid) hydrogels intended for colon-specific drug delivery. Carbohyd Polym 82(2):440–44510.1016/j.carbpol.2010.04.086 ↗
14. Rao KM et al (2014) pH sensitive halloysite-sodium hyaluronate/poly (hydroxyethyl methacrylate) nanocomposites for colon cancer drug delivery. Appl Clay Sci 97:33–42
15. Chuah LH et al (2014) Cellular uptake and anticancer effects of mucoadhesive curcumin-containing chitosan nanoparticles. Colloids Surf B 116:228–23610.1016/j.colsurfb.2014.01.007 ↗
16. Zhang L et al (2011) Eudragit® S100 coated calcium pectinate microspheres of curcumin for colon targeting. J Microencapsul 28(7):659–66710.3109/02652048.2011.604436 ↗
17. Madan J et al (2014) Cyclodextrin complexes of reduced bromonoscapine in guar gum microspheres enhance colonic drug delivery. Mol Pharm 11(12):4339–434910.1021/mp500408n ↗
18. Dutta RK, Sahu S (2012) Development of a novel probe sonication assisted enhanced loading of 5-FU in SPION encapsulated pectin nanocarriers for magnetic targeted drug delivery system. Eur J Pharm Biopharm 82(1):58–6510.1016/j.ejpb.2012.05.007 ↗
19. Chen G-Y et al (2015) Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. Biomaterials 40:12–2210.1016/j.biomaterials.2014.11.034 ↗
20. Novoselov K et al (2005) Two-dimensional atomic crystals. Proc Natl Acad Sci USA 102(30):10451–1045310.1073/pnas.0502848102 ↗
21. Calizo I et al (2007) Temperature dependence of the Raman spectra of graphene and graphene multilayers. Nano Lett 7(9):2645–264910.1021/nl071033g ↗
22. Liu L et al (2008) Graphene oxidation: thickness-dependent etching and strong chemical doping. Nano Lett 8(7):1965–197010.1021/nl0808684 ↗
23. Huang JC (2002) Carbon black filled conducting polymers and polymer blends. Adv Polym Technol 21(4):299–31310.1002/adv.10025 ↗
24. Ishigami M et al (2007) Atomic structure of graphene on SiO2. Nano Lett 7(6):1643–164810.1021/nl070613a ↗
25. Yan J et al (2007) Raman scattering and tunable electron–phonon coupling in single layer graphene. Solid State Commun 143(1):39–4310.1016/j.ssc.2007.04.022 ↗
26. Chen G-Y et al (2012) A graphene-based platform for induced pluripotent stem cells culture and differentiation. Biomaterials 33(2):418–42710.1016/j.biomaterials.2011.09.071 ↗
27. Zhang L et al (2010) Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small 6(4):537–54410.1002/smll.200901680 ↗
28. Tao Y et al (2014) Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy. Biomaterials 35(37):9963–997110.1016/j.biomaterials.2014.08.036 ↗
29. Chen GY et al (2014) Graphene oxide triggers toll-like receptors/autophagy responses in vitro and inhibits tumor growth in vivo. Adv Healthc Mater 3(9):1486–149510.1002/adhm.201300591 ↗
30. Danafar H et al (2017) Polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as carrier for delivery of hydrophilic and hydrophobic drugs: a comparison study. J Pharm Investig. doi: 10.1007/s40005-017-0334-810.1007/s40005-017-0334-8 ↗
31. Nosrati H et al (2017) Green and one-pot surface coating of iron oxide magnetic nanoparticles (IONPs) with natural amino acids and its biocompatibility investigation. Appl Organomet Chem. doi: 10.1002/aoc.406910.1002/aoc.4069 ↗
32. Gharebaghi F et al (2017) Preparation of wormlike polymeric nanoparticles coated with silica for delivery of methotrexate and evaluation of anticancer activity against MCF7 cells. J Biomater Appl 31(9):1305–131610.1177/0885328217698063 ↗
33. Nosrati H et al (2017) New advances strategies for surface functionalization of iron oxide magnetic nano particles (IONPs). Res Chem Intermed. doi: 10.1007/s11164-017-3084-310.1007/s11164-017-3084-3 ↗
34. Rasmussen JW et al (2010) Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert Opin Drug Deliv 7(9):1063–107710.1517/17425247.2010.502560 ↗
35. Rahimi-Nasrabadi M et al (2016) Synthesis and characterization of ZnFe2−xYbxO4–graphene nanocomposites by sol–gel method. J Mater Sci Mater Electron 27(11):11940–1194510.1007/s10854-016-5340-5 ↗
36. Vallet-Regí M, Balas F, Arcos D (2007) Mesoporous materials for drug delivery. Angew Chem Int Ed 46(40):7548–755810.1002/anie.200604488 ↗
37. Lopez T et al (2009) Kinetic study of controlled release of VPA and DPH antiepileptic drugs using biocompatible nanostructured sol–gel TiO2. J Mater Sci 44(20):5459–5468. doi: 10.1007/s10853-009-3745-810.1007/s10853-009-3745-8 ↗
38. Hamadanian M, Rostami M, Jabbari V (2017) Graphene-supported C–N–S tridoped TiO2 photo-catalyst with improved band gap and charge transfer properties. J Mater Sci Mater Electron 28(20):15637–1564610.1007/s10854-017-7452-y ↗
39. Rostami M et al (2017) Facile synthesis and characterization of TiO2–graphene–ZnFe2−xTbxO4 ternary nano-hybrids. J Mater Sci. doi: 10.1007/s10853-017-0934-810.1007/s10853-017-0934-8 ↗
40. Sun H et al (2014) A comparative study of reduced graphene oxide modified TiO2, ZnO and Ta2O5 in visible light photocatalytic/photochemical oxidation of methylene blue. Appl Catal B 146:162–16810.1016/j.apcatb.2013.03.027 ↗
41. Li M et al (2013) In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide. J Mater Chem B 1(4):475–48410.1039/C2TB00053A ↗
42. Asl SK, Rad MK, Sadrnezhaad S (2011) Hydrothermal preparation of TiO2–ZnO nano core‐shell structure with quantum size effect. In: AIP conference proceedings, vol 1400. doi: 10.1063/1.366315610.1063/1.3663156 ↗
43. Ganesh M et al (2012) Drug release evaluation of mesoporous TiO2: a nano carrier for duloxetine. In: Computer applications for modeling, simulation, and automobile, vol 341. Springer, pp 237–24310.1007/978-3-642-35248-5_33 ↗
44. Anchieta CG et al (2014) Effects of solvent diols on the synthesis of ZnFe2O4 particles and their use as heterogeneous photo-Fenton catalysts. Materials 7(9):6281–629010.3390/ma7096281 ↗
45. Song M, Xu J (2013) Preparation of polyethylenimine-functionalized graphene oxide composite and its application in electrochemical ammonia sensors. Electroanalysis 25(2):523–53010.1002/elan.201200376 ↗
46. Upadhyaya L et al (2015) Efficient water soluble nanostructured ZnO grafted O-carboxymethyl chitosan/curcumin-nanocomposite for cancer therapy. Process Biochem 50(4):678–68810.1016/j.procbio.2014.12.029 ↗
47. Danafar H et al (2017) Drug-conjugated PLA–PEG–PLA copolymers: a novel approach for controlled delivery of hydrophilic drugs by micelle formation. Pharm Dev Technol 22(8):947–95710.3109/10837450.2015.1125920 ↗
48. Al-Johani MS, Al-Zaghayer Y, Al-Mayman SI (2015) TiO2/ZnO photocatalytic activity for hydrogen production. Int Sci J Environ Sci 4:1–8
49. Liang Y et al (2015) Preparation of porous 3D Ce-doped ZnO microflowers with enhanced photocatalytic performance. RSC Adv 5(74):59887–5989410.1039/C5RA08519E ↗
50. Seeli DS et al (2016) Guar gum succinate-sodium alginate beads as a pH-sensitive carrier for colon-specific drug delivery. Int J Biol Macromol 91:45–5010.1016/j.ijbiomac.2016.05.057 ↗
51. Hanley C et al (2008) Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles. Nanotechnology 19(29):29510310.1088/0957-4484/19/29/295103 ↗
52. Wang H et al (2009) Fluorescent dye encapsulated ZnO particles with cell-specific toxicity for potential use in biomedical applications. J Mater Sci Mater Med 20(1):1110.1007/s10856-008-3541-z ↗