Magnetic nanoparticles: material engineering and emerging applications in lithography and biomedicine
Source abstract
Abstract
We present an interdisciplinary overview of material engineering and emerging applications of iron oxide nanoparticles. We discuss material engineering of nanoparticles in the broadest sense, emphasizing size and shape control, large-area self-assembly, composite/hybrid structures, and surface engineering. This is followed by a discussion of several non-traditional, emerging applications of iron oxide nanoparticles, including nanoparticle lithography, magnetic particle imaging, magnetic guided drug delivery, and positive contrast agents for magnetic resonance imaging. We conclude with a succinct discussion of the pharmacokinetics pathways of iron oxide nanoparticles in the human body -- an important and required practical consideration for any in vivo biomedical application, followed by a brief outlook of the field.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Iron oxide chemistry and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
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1. Casbeer E, Sharma VK, Li XZ (2012) Synthesis and photocatalytic activity of ferrites under visible light: a review. Sep Purif Technol 87:1–1410.1016/j.seppur.2011.11.034 ↗
2. Mangrulkar PA, Polshettiwar V, Labhsetwar NK, Varma RS, Rayalu SS (2012) Nano-ferrites for water splitting: unprecedented high photocatalytic hydrogen production under visible light. Nanoscale 4:5202–520910.1039/c2nr30819c ↗
3. Han SB, Kang TB, Joo OS, Jung KD (2007) Water splitting for hydrogen production with ferrites. Sol Energy 81:623–62810.1016/j.solener.2006.08.012 ↗
4. Pankhurst QA, Connolly J, Jones SK, Dobson J (2003) Applications of magnetic nanoparticles in biomedicine. J Phys D 36:R167–R18110.1088/0022-3727/36/13/201 ↗
5. Krishnan KM (2010) Biomedical nanomagnetics: a spin through possibilities in imaging, diagnostics, and therapy. IEEE Trans Magn 46:2523–255810.1109/TMAG.2010.2046907 ↗
6. Plank C, Vlaskou D, Schillinger U, Mykhaylyk O (2011) MagnetofectionTM platform: from magnetic nanoparticles to novel nucleic acid therapeutics. Ther Deliv 2:717–72610.4155/tde.11.37 ↗
7. Massoud TF, Gambhir SS (2003) Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 17:545–58010.1101/gad.1047403 ↗
8. Jain RK (1998) The next frontier of molecular medicine: delivery of therapeutics. Nat Med 4:655–65710.1038/nm0698-655 ↗
9. Ito A, Shinkai M, Honda H, Kobayashi T (2005) Review: medical application of functionalized magnetic nanoparticles. J Biosci Bioeng 100:1–1110.1263/jbb.100.1 ↗
10. Liang QL, Macher T, Xu YL, Bao YP, Cassady CJ (2014) MALDI MS in-source decay of glycans using a glutathione-capped iron oxide nanoparticle matrix. Anal Chem 86:8496–850310.1021/ac502422a ↗
11. Baldi G, Bonacchi D, Innocenti C, Lorenzi G, Sangregorio C (2007) Cobalt ferrite nanoparticles: the control of the particle size and surface state and their effects on magnetic properties. J Magn Magn Mater 311:10–1610.1016/j.jmmm.2006.11.157 ↗
12. Vestal CR, Zhang ZJ (2003) Effects of surface coordination chemistry on the magnetic properties of MnFe2O4 spinel ferrite nanoparticles. J Am Chem Soc 125:9828–983310.1021/ja035474n ↗
13. Song O, Zhang ZJ (2004) Shape control and associated magnetic properties of spinel cobalt ferrite nanocrystals. J Am Chem Soc 126:6164–616810.1021/ja049931r ↗
14. Palchoudhury S, Xu Y, Goodwin J, Bao Y (2011) Synthesis of iron oxide nanoworms. J Appl Phys 109:07E31410.1063/1.3549600 ↗
15. Palchoudhury S, Xu YL, Rushdi A, Holler RA, Bao YP (2012) Controlled synthesis of iron oxide nanoplates and nanoflowers. Chem Commun 48:10499–1050110.1039/c2cc35945f ↗
16. Palchoudhury S, An W, Xu YL, Qin Y, Zhang ZT, Chopra N et al (2011) Synthesis and growth mechanism of iron oxide nanowhiskers. Nano Lett 11:1141–114610.1021/nl200136j ↗
17. Peddis D, Cannas C, Musinu A, Piccaluga G (2009) Magnetism in nanoparticles: beyond the effect of particle size. Chem-A Eur J 15:7822–782910.1002/chem.200802513 ↗
18. Peddis D, Cannas C, Musinu A, Ardu A, Orru F, Fiorani D et al (2013) Beyond the effect of particle size: influence of CoFe2O4 nanoparticle arrangements on magnetic properties. Chem Mater 25:2005–201310.1021/cm303352r ↗
19. Lee J-H, Jang J-T, Choi J-S, Moon SH, Noh S-H, Kim J-W et al (2011) Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nano 6:418–42210.1038/nnano.2011.95 ↗
20. Mohapatra J, Mitra A, Bahadur D, Aslam M (2013) Surface controlled synthesis of MFe2O4 (M = Mn, Fe Co, Ni and Zn) nanoparticles and their magnetic characteristics. CrystEngComm 15:524–53210.1039/C2CE25957E ↗
21. Li QL, Wang YF, Chang CB (2010) Study of Cu Co, Mn and La doped NiZn ferrite nanorods synthesized by the coprecipitation method. J Alloy Compd 505:523–52610.1016/j.jallcom.2010.06.132 ↗
22. Xu Y, Sherwood J, Qin Y, Holler RA, Bao Y (2015) A general approach to the synthesis and detailed characterization of magnetic ferrite nanocubes. Nanoscale 7:12641–1264910.1039/C5NR03096J ↗
23. Scherer C, Neto AMF (2005) Ferrofluids: properties and applications. Braz J Phys 35:718–72710.1590/S0103-97332005000400018 ↗
24. Xie J, Huang J, Li X, Sun S, Chen X (2009) Iron oxide nanoparticle platform for biomedical applications. Curr Med Chem 16:1278–129410.2174/092986709787846604 ↗
25. Namdeo M, Saxena S, Tankhiwale R, Bajpai M, Mohan YM, Bajpai SK (2008) Magnetic nanoparticles for drug delivery applications. J Nanosci Nanotechnol 8:3247–327110.1166/jnn.2008.399 ↗
26. Gazeau F, Levy M, Wilhelm C (2008) Optimizing magnetic nanoparticle design for nanothermotherapy. Nanomedicine 3:831–84410.2217/17435889.3.6.831 ↗
27. Reimer P, Balzer T (2003) Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications. Eur Radiol 13:1266–127610.1007/s00330-002-1721-7 ↗
28. Park M, Lee N, Choi SH, An K, Yu SH, Kim JH et al (2011) Large-scale synthesis of ultrathin manganese oxide nanoplates and their applications to T1 MRI contrast agents. Chem Mater 23:3318–332410.1021/cm200414c ↗
29. Macher T, Totenhagen J, Sherwood J, Qin Y, Gurler D, Bolding MS et al (2015) Ultrathin iron oxide nanowhiskers as positive contrast agents for magnetic resonance imaging. Adv Funct Mater 25:490–49410.1002/adfm.201403436 ↗
30. Park JH, von Maltzahn G, Zhang LL, Schwartz MP, Ruoslahti E, Bhatia SN et al (2008) Magnetic iron oxide nanoworms for tumor targeting and imaging. Adv Mater 20:1630–163510.1002/adma.200800004 ↗
31. Lee N, Choi Y, Lee Y, Park M, Moon WK, Choi SH et al (2012) Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r2 relaxivity for highly sensitive in vivo MRI of tumors. Nano Lett 12:3127–313110.1021/nl3010308 ↗
32. Guardia P, Di Corato R, Lartigue L, Wilhelm C, Espinosa A, Garcia-Hernandez M et al (2012) Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment. ACS Nano 6:3080–309110.1021/nn2048137 ↗
33. Ferguson RM, Khandhar AP, Kemp SJ, Arami H, Saritas EU, Croft LR et al (2015) Magnetic particle imaging with tailored iron oxide nanoparticle tracers. IEEE Trans Med Imaging 34:1077–108410.1109/TMI.2014.2375065 ↗
34. Majetich SA, Sachan M (2006) Magnetostatic interactions in magnetic nanoparticle assemblies: energy, time and length scales. J Phys D 39:R407–R42210.1088/0022-3727/39/21/R02 ↗
35. Majetich SA, Wen T, Mefford OT (2013) Magnetic nanoparticles. MRS Bull 38:899–90310.1557/mrs.2013.230 ↗
36. Talapin DV, Murray CB (2005) PbSe nanocrystal solids for n- and p-channel thin film field-effect transistors. Science 310:86–8910.1126/science.1116703 ↗
37. Kim TH, Cho KS, Lee EK, Lee SJ, Chae J, Kim JW et al (2011) Full-colour quantum dot displays fabricated by transfer printing. Nat Photonics 5:176–18210.1038/nphoton.2011.12 ↗
38. Han ST, Zhou Y, Xu ZX, Huang LB, Yang XB, Roy VAL (2012) Microcontact printing of ultrahigh density gold nanoparticle monolayer for flexible flash memories. Adv Mater 24:3556–356110.1002/adma.201201195 ↗
39. Nie ZH, Petukhova A, Kumacheva E (2010) Properties and emerging applications of self-assembled structures made from inorganic nanoparticles. Nat Nanotechnol 5:15–2510.1038/nnano.2009.453 ↗
40. Zhang W, Wen TL, Krishnan KM (2012) Positive exchange bias and upward magnetic relaxation in a Fe-film/CoO-nanoparticle hybrid system. Appl Phys Lett 101:132401 (6 pp)10.1063/1.4754610 ↗
41. Majetich SA, Wen T, Booth RA (2011) Functional magnetic nanoparticle assemblies: formation, collective behavior, and future directions. ACS Nano 5:6081–608410.1021/nn202883f ↗
42. Bao YP, Beerman M, Krishnan KM (2004) Controlled self-assembly of colloidal cobalt nanocrystals mediated by magnetic interactions. J Magn Magn Mater 272:E1367–E136810.1016/j.jmmm.2003.12.219 ↗
43. Grzelczak M, Vermant J, Furst EM, Liz-Marzan LM (2010) Directed self-assembly of nanoparticles. ACS Nano 4:3591–360510.1021/nn100869j ↗
44. Bigioni TP, Lin XM, Nguyen TT, Corwin EI, Witten TA, Jaeger HM (2006) Kinetically driven self assembly of highly ordered nanoparticle monolayers. Nat Mater 5:265–27010.1038/nmat1611 ↗
45. Huang JX, Kim F, Tao AR, Connor S, Yang PD (2005) Spontaneous formation of nanoparticle stripe patterns through dewetting. Nat Mater 4:896–90010.1038/nmat1517 ↗
46. Whitesides GM, Grzybowski B (2002) Self-assembly at all scales. Science 295:2418–242110.1126/science.1070821 ↗
47. Talapin DV, Shevchenko EV, Murray CB, Titov AV, Kral P (2007) Dipole-dipole interactions in nanoparticle superlattices. Nano Lett 7:1213–121910.1021/nl070058c ↗
48. Liddle JA, Cui Y, Alivisatos P (2004) Lithographically directed self-assembly of nanostructures. J Vac Sci Technol B 22:3409–341410.1116/1.1821572 ↗
49. Lin XM, Jaeger HM, Sorensen CM, Klabunde KJ (2001) Formation of long-range-ordered nanocrystal superlattices on silicon nitride substrates. J Phys Chem B 105:3353–335710.1021/jp0102062 ↗
50. Yin YD, Lu Y, Gates B, Xia YN (2001) Template-assisted self-assembly: a practical route to complex aggregates of monodispersed colloids with well-defined sizes, shapes, and structures. J Am Chem Soc 123:8718–872910.1021/ja011048v ↗
51. Bishop KJM, Wilmer CE, Soh S, Grzybowski BA (2009) Nanoscale forces and their uses in self-assembly. Small 5:1600–163010.1002/smll.200900358 ↗
52. Cheng GJ, Romero D, Fraser GT, Walker ARH (2005) Magnetic-field-induced assemblies of cobalt nanoparticles. Langmuir 21:12055–1205910.1021/la0506473 ↗
53. Shevchenko EV, Talapin DV, Kotov NA, O’Brien S, Murray CB (2006) Structural diversity in binary nanoparticle superlattices. Nature 439:55–5910.1038/nature04414 ↗
54. Gao YH, Bao YP, Beerman M, Yasuhara A, Shindo D, Krishnan KM (2004) Superstructures of self-assembled cobalt nanocrystals. Appl Phys Lett 84:3361–336310.1063/1.1723687 ↗
55. Wen TL, Majetich SA (2011) Ultra-large-area self-assembled mono layers of nanoparticles. ACS Nano 5:8868–887610.1021/nn2037048 ↗
56. Wen T, Zhang D, Wen Q, Zhang H, Liao Y, Li Q et al (2015) Magnetic nanoparticle assembly arrays prepared by hierarchical self-assembly on a patterned surface. Nanoscale 7:4906–491110.1039/C4NR07489K ↗
57. Wen TL, Brush LN, Krishnan KM (2014) A generalized diffusion model for growth of nanoparticles synthesized by colloidal methods. J Colloid Interface Sci 419:79–8510.1016/j.jcis.2013.12.018 ↗
58. Puntes VF, Krishnan KM, Alivisatos AP (2001) Colloidal nanocrystal shape and size control: the case of cobalt. Science 291:2115–211710.1126/science.1057553 ↗
59. Bao YP, An W, Turner CH, Krishnan KM (2010) The critical role of surfactants in the growth of cobalt nanoparticles. Langmuir 26:478–48310.1021/la902120e ↗
60. Lee D-E, Koo H, Sun I-C, Ryu JH, Kim K, Kwon IC (2012) Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem Soc Rev 41:2656–267210.1039/C2CS15261D ↗
61. Jin YD, Jia CX, Huang SW, O’Donnell M, Gao XH (2010) Multifunctional nanoparticles as coupled contrast agents. Nat Commun 1:1–810.1038/ncomms1042 ↗
62. Bao YP, Calderon H, Krishnan KM (2007) Synthesis and characterization of magnetic-optical Co-Au core-shell nanoparticles. J Phys Chem C 111:1941–194410.1021/jp066871y ↗
63. Corr SA, Rakovich YP, Gun’ko YK (2008) Multifunctional magnetic-fluorescent nanocomposites for biomedical applications. Nanoscale Res Lett 3:87–10410.1007/s11671-008-9122-8 ↗
64. Xu YL, Palchoudhury S, Qin Y, Macher T, Bao YP (2012) Make conjugation simple: a facile approach to integrated nanostructures. Langmuir 28:8767–877210.1021/la301200g ↗
65. Arami H, Khandhar AP, Tomitaka A, Yu E, Goodwill PW, Conolly SM et al (2015) In vivo multimodal magnetic particle imaging (MPI) with tailored magneto/optical contrast agents. Biomaterials 52:251–26110.1016/j.biomaterials.2015.02.040 ↗
66. Arami H, Krishnan KM (2014) Intracellular performance of tailored nanoparticle tracers in magnetic particle imaging. J Appl Phys 115:17B306 (3 pp)10.1063/1.4867756 ↗
67. Gonzales-Weimuller M, Zeisberger M, Krishnan KM (2009) Size-dependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia. J Magn Magn Mater 321:1947–195010.1016/j.jmmm.2008.12.017 ↗
68. Gonzales M, Krishnan KM (2005) Synthesis of magnetoliposomes with monodisperse iron oxide nanocrystal cores for hyperthermia. J Magn Magn Mater 293:265–27010.1016/j.jmmm.2005.02.020 ↗
69. Clift MJD, Rothen-Rutishauser B, Brown DM, Duffin R, Donaldson K, Proudfoot L et al (2008) The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line. Toxicol Appl Pharmacol 232:418–42710.1016/j.taap.2008.06.009 ↗
70. Chouly C, Pouliquen D, Lucet I, Jeune JJ, Jallet P (1996) Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. J Microencapsul 13:245–25510.3109/02652049609026013 ↗
71. Moghimi SM, Hunter AC, Murray JC (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 53:283–31810.1016/S0031-6997(24)01494-7 ↗
72. Lunov O, Syrovets T, Rocker C, Tron K, Nienhaus GU, Rasche V et al (2010) Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes. Biomaterials 31:9015–902210.1016/j.biomaterials.2010.08.003 ↗
73. Ferguson RM, Khandhar AP, Arami H, Hua L, Hovorka O, Krishnan KM (2013) Tailoring the magnetic and pharmacokinetic properties of iron oxide magnetic particle imaging tracers. Biomed Eng 58:493–50710.1515/bmt-2012-0058 ↗
74. Kittel C (1949) Physical theory of ferromagnetic domains. Rev Modern Phys 21:541–58910.1103/RevModPhys.21.541 ↗
75. Krishnan KM, Pakhomov AB, Bao Y, Blomqvist P, Chun Y, Gonzales M et al (2006) Nanomagnetism and spin electronics: materials, microstructure and novel properties. J Mater Sci 41:793–815. doi: 10.1007/s10853-006-6564-110.1007/s10853-006-6564-1 ↗
76. Frei SSEH, Treves D (1957) Critical size and nucleation field of ideal ferromagnetic particles. Phys Rev 106:446–45510.1103/PhysRev.106.446 ↗
77. Puntes VF, Krishnan K, Alivisatos AP (2002) Synthesis of colloidal cobalt nanoparticles with controlled size and shapes. Top Catal 19:145–14810.1023/A:1015252904412 ↗
78. Bao YP, Beerman M, Pakhomov AB, Krishnan KM (2005) Controlled crystalline structure and surface stability of cobalt nanocrystals. J Phys Chem B 109:7220–722210.1021/jp044363n ↗
79. Bao Y, An W, Turner CH, Krishnan K (2009) The critical role of surfactants in the growth of cobalt nanoparticles. Langmuir 26:478–48310.1021/la902120e ↗
80. Carpenter EE (2001) Iron nanoparticles as potential magnetic carriers. J Magn Magn Mater 225:17–2010.1016/S0304-8853(00)01222-1 ↗
81. Guo DD, Wu CH, Li XM, Jiang H, Wang XM, Chen BA (2008) In vitro cellular uptake and cytotoxic effect of functionalized nickel nanoparticles on leukemia cancer cells. J Nanosci Nanotechnol 8:2301–230710.1166/jnn.2008.311 ↗
82. Bao Y, Pakhomov AB, Krishnan KM (2005) A general approach to synthesis of nanoparticles with controlled morphologies and magnetic properties. J Appl Phys 97:10J317 (3 pp)10.1063/1.1853991 ↗
83. Sun SH, Murray CB, Weller D, Folks L, Moser A (2000) Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices. Science 287:1989–199210.1126/science.287.5460.1989 ↗
84. Joseyphus RJ, Shinoda K, Sato Y, Tohji K, Jeyadevan B (2008) Composition controlled synthesis of fcc-FePt nanoparticles using a modified polyol process. J Mater Sci 43:2402–2406. doi: 10.1007/s10853-007-1951-910.1007/s10853-007-1951-9 ↗
85. Wang HL, Zhang Y, Huang Y, Zeng Q, Hadjipanayis GC (2004) CoPt nanoparticles by chemical reduction. J Magn Magn Mater 272:E1279–E128010.1016/j.jmmm.2004.01.050 ↗
86. Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995–402110.1016/j.biomaterials.2004.10.012 ↗
87. Hyeon T, Lee SS, Park J, Chung Y, Na HB (2001) Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. J Am Chem Soc 123:12798–1280110.1021/ja016812s ↗
88. Rockenberger J, Scher EC, Alivisatos AP (1999) A new nonhydrolytic single-precursor approach to surfactant-capped nanocrystals of transition metal oxides. J Am Chem Soc 121:11595–1159610.1021/ja993280v ↗
89. Xie J, Peng S, Brower N, Pourmand N, Wang SX, Sun SH (2006) One-pot synthesis of monodisperse iron oxide nanoparticles for potential biomedical applications. Pure Appl Chem 78:1003–101410.1351/pac200678051003 ↗
90. Park J, An KJ, Hwang YS, Park JG, Noh HJ, Kim JY et al (2004) Ultra-large-scale syntheses of monodisperse nanocrystals. Nat Mater 3:891–89510.1038/nmat1251 ↗
91. Yu WW, Falkner JC, Yavuz CT, Colvin VL (2004) Synthesis of monodisperse iron oxide nanocrystals by thermal decomposition of iron carboxylate salts. Chem Commun 2306–2307
92. Xu YL, Qin Y, Palchoudhury S, Bao YP (2011) Water-soluble iron oxide nanoparticles with high stability and selective surface functionality. Langmuir 27:8990–899710.1021/la201652h ↗
93. Xu YL, Baiu DC, Sherwood JA, McElreath MR, Qin Y, Lackey KH et al (2014) Linker-free conjugation and specific cell targeting of antibody functionalized iron-oxide nanoparticles. J Mater Chem B 2:6198–620610.1039/C4TB00840E ↗
94. Kim BH, Lee N, Kim H, An K, Park YI, Choi Y et al (2011) Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T-1 magnetic resonance imaging contrast agents. J Am Chem Soc 133:12624–1263110.1021/ja203340u ↗
95. Palchoudhury S, Xu YL, An W, Turner CH, Bao YP (2010) Platinum attachments on iron oxide nanoparticle surfaces. J Appl Phys 107:09B311 (3 pp)10.1063/1.3355899 ↗
96. Young AG, Al-Salim N, Green DP, McQuillan AJ (2008) Attenuated total reflection infrared studies of oleate and trioctylphosphine oxide ligand adsorption and exchange reactions on CdS quantum dot films. Langmuir 24:3841–384910.1021/la703655v ↗
97. Hufschmid R, Arami H, Ferguson RM, Gonzales M, Teeman E, Brush LN, Browning ND, Krishnan KM (2015) Nanoscale 7:11142–1115410.1039/C5NR01651G ↗
98. Hai HT, Yang HT, Kura H, Hasegawa D, Ogata Y, Takahashi M et al (2010) Size control and characterization of wustite (core)/spinel (shell) nanocubes obtained by decomposition of iron oleate complex. J Colloid Interface Sci 346:37–4210.1016/j.jcis.2010.02.025 ↗
99. Kovalenko MV, Bodnarchuk MI, Lechner RT, Hesser G, Schaffler F, Heiss W (2007) Fatty acid salts as stabilizers in size- and shape-controlled nanocrystal synthesis: the case of inverse spinel iron oxide. J Am Chem Soc 129:6352–635310.1021/ja0692478 ↗
100. Xu ZC, Shen CM, Tian YA, Shi XZ, Gao HJ (2010) Organic phase synthesis of monodisperse iron oxide nanocrystals using iron chloride as precursor. Nanoscale 2:1027–103210.1039/b9nr00400a ↗