TPMS-based gyroid cellular Ni@Al2O3/CoCrMo alloys fabricated by selective laser melting: An In vitro and In vivo study
Source abstract
Abstract
In this study, the cancellous-bone like and cortical-bone like TPMS-based Gyroid porous Ni@Al 2 O 3 /CoCrMo scaffolds with homogenous porosity of 60% (G60), 75% (G75) and radially graded porosity of 50%-80% (F70) were fabricated by Selective Laser Melting (SLM) process. The effects of porosity on the compressive behavior and elastic modulus were investigated, where the F70 scaffold with radially graded porosity performed the best match with healthy adults. By measuring the release of cobalt and chromium ions in the extracting liquid and cytotoxicity of porous scaffolds, both G75 and F70 scaffolds presented lower ion release rate and excellent biocompatibility. After implantation in rabbits for 8 weeks, the F70 scaffold demonstrated approximately 90% bone ingrowth with enhanced osteointegration. The outstanding biological properties of SLM-processed TPMS porous Ni@Al 2 O 3 /CoCrMo scaffolds have made it suitable for the metallic orthopedic implants in the field of hip joint replacement.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cellular and Composite Structures · Additive Manufacturing Materials and Processes · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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