Expanded perlite and barium sulfate as enablers for biomedical applications of 3D-printed PLA biocomposites: Thermo-mechanical properties, bacterial adhesion inhibition, and antimicrobial activity
Source abstract
Abstract
Enhancing the performance of PLA biomaterials for scaffolding requires suitable mechanical properties, controlled surface features, and antibacterial activity. In this work, PLA-based biocomposite filaments were developed using expanded perlite of low (EPL) and high (EPH) density, along with barium sulfate with 10 (BS10) and 20 μm (BS20) particle sizes for 3D printing. Both fillers maintained the thermal stability of PLA, with a Tg around 58 °C. Melt flow indices (EP: 6–13; BS: 6–9 g/10 min) indicated good processability, while rheological analysis showed reduced viscoelasticity. EP tensile strength values remained within the range required for wound healing scaffolds (5–40 MPa). BS composites exhibited improved tensile properties, with BS10 reaching around 40 MPa across all loadings, and BS20 between 35 and 40 MPa, with optimal performance at 5 wt.%. Both EPH and BS20 increased surface roughness and decreased bacterial adhesion (up to 88%), highlighting their potential for functional PLA scaffolds.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: biodegradable polymer synthesis and properties · Bone Tissue Engineering Materials · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (78)
Show source-provided references
1. Tissue engineering: understanding the role of biomaterials and biophysical forces on cell functionality through computational and structural biotechnology analytical methods10.1016/j.csbj.2019.04.008 ↗
2. Current applications of poly(lactic acid) composites in tissue engineering and drug delivery10.1016/j.compositesb.2020.108238 ↗
3. Research progress in 3D printed biobased and biodegradable polyester/ceramic composite materials: applications and challenges in bone tissue engineering10.1021/acsami.4c15719 ↗
4. Three-dimensional printed polylactic acid scaffolds promote bone-like matrix deposition in vitro10.1021/acsami.9b02502 ↗
5. Combining bioresorbable polyesters and bioactive glasses: orthopedic applications of composite implants and bone tissue engineering scaffolds
6. The role of biomaterials-based scaffolds in advancing skin tissue construct10.1016/j.jtv.2025.100858 ↗
7. Three-dimensional bio-derived materials for biomedical applications: challenges and opportunities10.1039/D4RA07531E ↗
8. 3D printed personalized assistive devices: a material, technique, and medical condition perspective
9. 4D printing for minimally invasive biomedical applications: programmable smart materials for deployable devices, drug delivery, and tissue regeneration
10. Recent advances in additive manufacturing of impact-resistant structures with high-performance polymers and their composites
11. Morphological and mechanical characterization of 3D printed PLA scaffolds with controlled porosity for trabecular bone tissue replacement10.1016/j.msec.2020.111528 ↗
12. Printability versus durability in 3D-printed biocomposites: unraveling the distinct roles of flax and hemp fibers in PLA-Based filaments10.1016/j.jmrt.2026.03.120 ↗
13. 3D-printed polylactic acid scaffolds for bone tissue engineering: bioactivity enhancing strategies based on composite filaments and coatings
14. Design of novel poly(l-lactide)-based shape memory multiblock copolymers for biodegradable esophageal stent application
15. Design, fabrication, and characterization of 3D-printed ABS and PLA scaffolds potentially for tissue engineering10.1016/j.rineng.2023.101685 ↗
16. Engineering three-dimensional-printed bioactive polylactic acid alginate composite scaffolds with antibacterial and in vivo osteoinductive capacity10.1021/acsami.2c19300 ↗
17. Silylated softwood and hardwood lignin: impact on thermomechanical and interfacial properties of PLA biocomposites10.1021/acs.biomac.5c01179 ↗
18. 3D printing technology; methods, biomedical applications, future opportunities and trends10.1016/j.jmrt.2021.07.050 ↗
19. Vat photopolymerization of polylactic acid/hydroxyapatite scaffolds with a unique combination of structural and compositional gradient for multiple-tissue regeneration
20. Additive manufacturing of PLA-Mg composite scaffolds for hard tissue engineering applications10.1016/j.jmbbm.2023.105655 ↗
21. Antioxidant pla composites containing lignin for 3D printing applications: a potential material for healthcare applications10.3390/pharmaceutics11040165 ↗
22. Durability of structural lightweight concrete containing expanded perlite aggregate10.1186/s40069-020-00425-w ↗
23. Utilization of waste expanded perlite as new effective supplementary cementitious material10.1016/j.jclepro.2016.10.018 ↗
24. Application of expanded perlite immobilized microorganisms in cementitious materials
25. The potential use of natural expanded perlite as a flame retardant additive for acrylonitrile‐butadiene‐styrene based composites10.1002/vnl.22047 ↗
26. Manufacturing of ABS/Expanded perlite filament for 3D printing of lightweight components through fused deposition modeling10.1016/j.matpr.2021.06.351 ↗
27. The biological synthesis of gold/perlite nanocomposite using Urtica dioica extract and its chitosan-capped derivative for healing wounds infected with methicillin-resistant Staphylococcus aureus10.1016/j.ijbiomac.2021.04.150 ↗
28. Morphological, cytotoxicity, and coagulation assessments of perlite as a new hemostatic biomaterial10.1039/D2RA07795G ↗
29. Understanding the toughness mechanism prompted by submicron rigid particles in polylactide/barium sulfate composites10.1016/j.polymertesting.2018.05.041 ↗
30. Investigation on the environmental‐friendly poly(lactic acid) composites based on precipitated barium sulfate: mechanical, thermal properties, and kinetic study of thermal degradation10.1002/app.47995 ↗
31. Crystallization and rheological properties of the eco-friendly composites based on poly (lactic acid) and precipitated barium sulfate10.1007/s10924-019-01557-1 ↗
32. Benefits of polydopamine as particle/matrix interface in Polylactide/PD-BaSO4 scaffolds10.3390/ijms21155480 ↗
33. PLA/SiO2 composites: influence of the filler modifications on the morphology, crystallization behavior, and mechanical properties10.1002/app.45367 ↗
34. Fly ash/glass fiber/carbon fiber-reinforced thermoset composites
35. Synthesis and characterization of lignin hydrogels for potential applications as drug eluting antimicrobial coatings for medical materials10.1021/acssuschemeng.8b01371 ↗
36. Poly(caprolactone)/lignin-based 3D-printed dressings loaded with a novel combination of bioactive agents for wound-healing applications
37. Comparison of different human tissue processing methods for maximization of bacterial recovery10.1007/s10096-018-3406-4 ↗
38. Jones · 1997 · vol. 18
39. Miles · 1930
40. Morphologies, mechanical properties and thermal stability of poly(lactic acid) toughened by precipitated barium sulfate10.1134/S0036024415110242 ↗
41. Can the melt flow index be used to predict the success of fused deposition modelling of commercial poly(lactic acid) filaments into 3D printed materials?10.1080/14658011.2017.1397308 ↗
42. On the performance of perlite as a mineral adsorbent for heavy metals ions and dye removal from industrial wastewater: a review of the state of the art10.1016/j.cscee.2023.100385 ↗
43. Controlling plasma-functionalized fillers for enhanced properties of PLA/znO biocomposites: effects of excess l -Lactic acid and biomedical implications10.1021/acsami.4c20196 ↗
44. Insights in the physicochemical and mechanical properties and characterization methodology of perlites10.3390/min14010113 ↗
45. Thermal, thermo-oxidative and thermomechanical degradation of PLA: a comparative study based on rheological, chemical and thermal properties10.1016/j.polymdegradstab.2018.02.011 ↗
46. Rotational molding of polylactide (PLA) composites filled with copper slag as a waste filler from metallurgical industry10.1016/j.polymertesting.2021.107449 ↗
47. Utilization of silica filler as reinforcement material of polylactic acid (PLA) in 3D printing applications: thermal, rheological, and mechanical performance10.3390/polym16101326 ↗
48. Uptake, localization and dissolution of barium sulfate nanoparticles in human lung cells explored by the combination of ICP-MS, TEM and NanoSIMS10.1016/j.jtemb.2025.127650 ↗
49. Micro vs nano: influence of filler size on the rheological and mechanical properties of highly-filled PLA/HAp and PCL/HAp composites10.1016/j.jmrt.2025.06.234 ↗
50. Effect of shape and size of filler particle on the aggregation and sedimentation behavior of the polymer composite10.1016/j.powtec.2020.02.054 ↗
51. Processing–property relationships in 3D printed PLA/graphene composites for synergistic enhancement of mechanical strength and electrical conductivity10.1016/j.jmrt.2025.12.269 ↗
52. The thermal properties of FDM printed polymeric materials: a review10.1016/j.polymdegradstab.2024.110902 ↗
53. 4D printing for minimally invasive biomedical applications: programmable smart materials for deployable devices, drug delivery, and tissue regeneration10.1016/j.matdes.2026.115555 ↗
54. Influence of 3D-printing deposition parameters on crystallinity and morphing properties of PLA-based materials10.1007/s40964-024-00608-x ↗
55. Manufacturing of ABS/expanded perlite filament for 3D printing of lightweight components through fused deposition modeling10.1016/j.matpr.2021.06.351 ↗
56. Nanoperlite effect on thermal , rheological , surface and cellular properties of poly lactic acid/nanoperlite nanocomposites for multipurpose applications
57. Wijesinghe · 2019
58. Mechanical properties of human skin in vivo : a comparative evaluation in 300 men and women10.1111/srt.12094 ↗
59. Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis10.1186/s12951-020-00755-7 ↗
60. Role of inorganic fillers on the physical aging and toughness loss of PLLA/BaSO 4 composites10.1021/acsapm.3c02112 ↗
61. X-ray protective materials from barium sulfate/amorphous cellulose/natural rubber composites10.1016/j.radphyschem.2022.110011 ↗
62. Impact of the nanoparticle incorporation in enhancing mechanical properties of polymers10.1016/j.rineng.2025.106151 ↗
63. Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy10.1038/sj.neo.7900071 ↗
64. Structural validation of oral mucosal tissue using optical coherence tomography10.1186/1758-3284-4-29 ↗
65. Non-destructive analysis of tablet coatings with optical coherence tomography10.1016/j.ejps.2011.06.017 ↗
66. Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaine10.1007/s13346-025-01855-3 ↗
67. Reservoir‐Type subcutaneous implantable devices containing porous rate controlling membranes for sustained delivery of risperidone
68. Design, formulation, and evaluation of novel dissolving microarray patches containing rilpivirine for intravaginal delivery10.1002/adhm.201801510 ↗
69. A novel transdermal protein delivery strategy via electrohydrodynamic coating of PLGA microparticles onto microneedles10.1021/acsami.9b22425 ↗
70. 3D-printed radiopaque polymer composites for the in situ monitoring of biodegradable medical implants
71. Enhancing 3D scaffold performance for bone tissue engineering: a comprehensive review of modification and functionalization strategies
72. Recent advances in biomaterials for 3D scaffolds: a review
73. Antibacterial activity of Superhydrophobic-SiO2 coatings to inhibit the growth of Escherichia coli and Staphylococcus aureus10.3390/coatings14091211 ↗
74. Antibacterial potential of Al2O3 nanoparticles against multidrug resistance strains of Staphylococcus aureus isolated from skin exudates10.1007/s11051-013-1970-1 ↗
75. Advances in antimicrobial coatings for preventing infections of head-related implantable medical devices10.3390/coatings14030256 ↗
76. Combating implant infections: shifting focus from bacteria to host
77. New filtering antimicrobial nonwovens with various carriers for biocides as respiratory protective materials against bioaerosol10.1080/10803548.2012.11076944 ↗
78. Nano-BaSO4: a novel antimicrobial additive to pellethane