An innovative route for incorporating pharmaceuticals into biodegradable metal matrices for drug delivery implants
Source abstract
Abstract
Metal particles can be welded without significant heating due to severe plastic deformation caused by high pressure torsion. This process has been used to consolidate metallic particles and incorporate ceramic materials into a metallic matrix. The present study demonstrates for the first time that this technique can also be used to incorporate pharmaceuticals into a metallic matrix. In addition, it shows that embedding pharmaceuticals in a biodegradable metal matrix enables the creation of composites with drug delivery capabilities. The results obtained here indicate the successful incorporation of ofloxacin, amphotericin B, and diclofenac sodium into a continuous magnesium matrix. The antifungal and antibacterial activities of the different composites are evaluated along with their drug release kinetics. A new class of biomaterials, biodegradable metals with integrated drug delivery functionality, is introduced in this study.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Aluminum Alloys Composites Properties · Corrosion Behavior and Inhibition
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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