Responses of rat bone marrow mesenchymal stem cells to graphene oxide films with different alkali treatment

Graphene oxide (GO) has been widely investigated in biomedical fields due to its excellent biocompatibility. In the present study, GO films were fabricated on titanium surface by cathode electrophoretic deposition with the help of Mg2+ and Al3+. Responses of rat bone marrow mesenchymal stem cells to GO films with different alkali treatment, including urea hydrothermal treatment and sodium hydroxide hydrothermal treatment, were investigated. The results indicated that GO films with urea hydrothermal treatment could promote cell proliferation and improve alkaline phosphatase activity. On the contrary, GO films with sodium hydroxide hydrothermal treatment inhibited cell proliferation. Keywords: Biomaterials, Electrodeposition, Alkali treatment, Graphene oxide, Cell proliferation, Titanium