MgB2-based biodegradable materials for orthopedic implants
Source abstract
Abstract
Bulk high density MgB2 and a composite material made of a PLA matrix and MgB2 powder inclusions were in vivo tested as candidates for biodegradable materials for orthopedic implants. A rat model was used. Implants were introduced into femoral bone, in transversal and longitudinal directions. Assessment of the implant–tissue interaction was performed by X-ray imaging, X-ray computer tomography, electron microscopy, cytology, and histopathology on samples at 40 and 90 days after surgery. Both materials are biocompatible, bone and adjacent soft tissue showing good tolerance of implants. Biodegradation of MgB2 is faster than for PLA-MgB2 composite, but in both cases, it is accompanied by bone regeneration. Results suggest that use of MgB2-containing composites can promote space and time control of degradation and promotes MgB2 as a promising material for fracture repair.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Layered Double Hydroxides Synthesis and Applications · Aluminum Alloys Composites Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (60)
Show source-provided references
1. Evaluation of in vitro corrosion behavior of zinc–hydroxyapatite and zinc–hydroxyapatite–iron as biodegradable composites10.1002/jbm.b.34712 ↗
2. A bioabsorbable microclip for laryngeal microsurgery: design and evaluation10.1016/j.actbio.2012.03.051 ↗
3. Biodegradable magnesium implants for orthopedic applications10.1007/s10853-012-6572-2 ↗
4. Biodegradable wound-closing devices for gastrointestinal interventions: degradation performance of the magnesium tip10.1016/j.msec.2011.03.012 ↗
5. A review on biomaterials in orthopedic bone plate application
6. Biocompatibility issues with modern implants in bone - a review for clinical orthopedics10.2174/1874325000802010066 ↗
7. Metallic biomaterials: current Challenges and Opportunities10.3390/ma10080884 ↗
8. Bone grafts and biomaterials substitutes for bone defect repair: a review
9. Recent advances on the development of magnesium alloys for biodegradable implants10.1016/j.actbio.2014.07.005 ↗
10. Magnesium and its alloys as orthopedic biomaterials: a review10.1016/j.biomaterials.2005.10.003 ↗
11. Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta10.1016/j.biomaterials.2006.05.029 ↗
12. Progress of biodegradable metals10.1016/j.pnsc.2014.08.014 ↗
13. First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby
14. Drug-eluting bioabsorbable magnesium stent10.1111/j.1540-8183.2004.04081.x ↗
15. Preliminary results after application of absorbable metal stents in patients with critical limb ischemia10.1583/04-1349R.1 ↗
16. Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial10.1016/S0140-6736(07)60853-8 ↗
17. Magnesium deficiency and increased inflammation: current perspectives10.2147/JIR.S136742 ↗
18. Synthesis and characterization of magnesium diboride nanosheets in alginate/polyvinyl alcohol scaffolds for bone tissue engineering10.1016/j.colsurfb.2021.111771 ↗
19. Evaluation of pristine and Eu₂O₃-added MgB₂ ceramics for medical applications: hardness, corrosion resistance, cytotoxicity and antibacterial activity10.1016/j.msec.2014.05.046 ↗
20. MgB2 powders and bioevaluation of their interaction with planktonic microbes, biofilms, and tumor cells10.1016/j.jmrt.2021.04.003 ↗
21. The importance of boron in biological systems10.1016/j.jtemb.2017.10.008 ↗
22. Chemistry and biochemistry of magnesium10.1016/S0098-2997(02)00087-0 ↗
23. Lithium and boron in human blood
24. Regulation of enzymatic activity − one possible role of dietary boron in higher animals and humans10.1007/BF02783139 ↗
25. Physiological roles and transport mechanisms of boron: perspectives from plants10.1007/s00424-007-0370-8 ↗
26. Dietary boron intake and prostate cancer risk
27. Boron sources, speciation and its potential impact on health10.1007/s11157-008-9140-0 ↗
28. Boron in human and animal nutrition10.1023/A:1004276311956 ↗
29. Antibacterial composite coatings of MgB2 powders embedded in PVP matrix10.1038/s41598-021-88885-2 ↗
30. In vitro evaluation of MgB2 powders as novel tools to fight fungal biodeterioration of heritage buildings and objects10.3389/fmats.2020.601059 ↗
31. Applicability of existing magnesium alloys as biomedical implant materials
32. Dual alloying improves the corrosion resistance of biodegradable Mg alloys prepared by selective laser melting10.1016/j.jma.2020.03.016 ↗
33. Degradable biomaterials based on magnesium corrosion10.1016/j.cossms.2009.04.001 ↗
34. Corrosion behavior of pristine and added MgB2 in phosphate buffered saline solution10.1088/1757-899X/40/1/012032 ↗
35. Modeling the neck for impact scenarios
36. Mechanical properties of MgB2 bulk fabricated by spark plasma sintering10.1016/j.phpro.2015.05.128 ↗
37. Biodegradable magnesium alloys: a review of material development and applications10.4028/www.scientific.net/JBBTE.12.25 ↗
38. Biodegradable surgical implants based on magnesium alloys - a review of current research10.1088/1757-899X/4/1/012011 ↗
39. Biodegradable orthopedic magnesium-Calcium (MgCa) alloys, processing, and corrosion performance10.3390/ma5010135 ↗
40. Compressive properties of pristine and SiC-Te-added MgB2 powders, green compacts and spark-plasma-sintered bulks10.1016/j.ceramint.2018.03.008 ↗
41. Infiltration behavior of molten Mg and its influence on microstructural evolution in SiC-doped MgB2 wires prepared by internal Mg diffusion process10.1016/j.jallcom.2018.01.012 ↗
42. High density MgB2 obtained by reactive liquid Mg infiltration10.1142/S0217979203016091 ↗
43. Spark plasma sintering of MgB2 in the two-temperature route10.1016/j.physc.2012.01.023 ↗
44. Sterilization techniques for biodegradable scaffolds in tissue engineering applications10.1177/2041731416648810 ↗
45. Osseointegration of 3D porous and solid Ti–6Al–4V implants - narrow gap push-out testing and experimental setup considerations10.1016/j.jmbbm.2020.104282 ↗
46. Seralp · 2019
47. Balint · 2011
48. Recommandations techniques et règles de bonne pratique pour la coloration de May-Grünwald-Giemsa: revue de la littérature et apport de l’assurance qualité10.1016/j.annpat.2015.05.019 ↗
49. Sharkey · 2021 · 12
50. Ordodi
51. Hematologic assessment in pet rats, mice, hamsters, and gerbils: blood sample collection and blood cell identification10.1016/j.cvex.2014.09.004 ↗
52. Bancroft · 2008
53. X-ray micro-tomography studies on carbon based composite materials for porosity network characterization10.1016/j.fusengdes.2011.04.079 ↗
54. Tiseanu · 2013
55. Vivo corrosion of four magnesium alloys and the associated bone response10.1016/j.biomaterials.2004.09.049 ↗
56. Incorporation of Mg particles into PDLLA regulates mesenchymal stem cell and macrophage responses10.1002/jbm.a.35625 ↗
57. Bioresorbable magnesium-reinforced PLA membrane for guided bone/tissue regeneration10.1016/j.jmbbm.2020.104061 ↗
58. In vitro degradation of a biodegradable polylactic acid/magnesium composite as potential bone augmentation material in the presence of titanium and PEEK dental implants10.1016/j.dental.2018.06.009 ↗
59. Development of biocompatible and fully biosabsorbable PLA/Mg films for tissue regeneration applications10.1016/j.actbio.2019.05.026 ↗
60. Impact of PLA/Mg films degradation on surface physical properties and biofilm survival10.1016/j.colsurfb.2019.110617 ↗