Next-generation nanomaterials for biomedical integration: Synergy, function, and translation
Source abstract
Abstract
While the first wave of biomedical nanomaterials provided novel tools for drug delivery, imaging, and diagnostics, the field is undergoing a significant transformation, moving beyond single-purpose nanoparticles toward sophisticated, multi-component nanosystems, including metal–organic frameworks (MOFs), nanofibers, and hybrid surface coatings designed for synergistic action. This perspective review analyzes emerging trends in biomedical engineering, highlighting toward integrating diagnostic, therapeutic, and regenerative functions into unified platforms. Examining recent advances—from MOFs that enhance drug efficacy to functionalized nanofibers that direct cell differentiation—we argue that the future lies in “the system is the solution.” We develop three main themes: (1) Synergistic therapeutics, where nanomaterials act as active partners; (2) Smart bio-interfaces, where structure and surface engineering command biological responses; and (3) The challenge of complexity, which emphasizes the need for advanced characterization and scalable synthesis. This perspective review outlines design principles, structure–function relationships, and key barriers that define next-generation biomedical nanomaterials.Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Nanoplatforms for cancer theranostics · Metal-Organic Frameworks: Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (85)
Show source-provided references
1. Y. Mao, J. Xie, F. Yang et al., Advances and prospects of precision nanomedicine in personalized tumor theranostics. Front. Cell Dev. Biol. 12, 1514399 (2024). https://doi.org/10.3389/fcell.2024.151439910.3389/fcell.2024.1514399 ↗
2. H. Azimizonuzi, A. Ghayourvahdat, M.H. Ahmed et al., A state-of-the-art review of the recent advances of theranostic liposome hybrid nanoparticles in cancer treatment and diagnosis. Cancer Cell Int. 25, 3610 (2025). https://doi.org/10.1186/s12935-024-03610-z10.1186/s12935-024-03610-z ↗
3. D.K. Gupta, S. Kumar, M.Y. Wani, MOF magic: zirconium-based frameworks in theranostic and bio-imaging applications. J. Mater. Chem. B 12(13), 2691–2710 (2024). https://doi.org/10.1039/D3TB02562D10.1039/D3TB02562D ↗
4. S. Sadiq, S. Khan, I. Khan et al., A critical review on metal-organic frameworks (MOFs)-based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects. Heliyon 10(3), e25521 (2024)10.1016/j.heliyon.2024.e25521 ↗
5. P. Sezgin, E. Gulcay-Ozcan, M. Vučkovski et al., Biomedical applications of metal-organic frameworks revisited. Ind. Eng. Chem. Res. 64(4), 1907–1932 (2025). https://doi.org/10.1021/acs.iecr.4c0369810.1021/acs.iecr.4c03698 ↗
6. M. Kamaraj, N. Moghimi, J. Chen et al., New dimensions of electrospun nanofiber material designs for biotechnological uses. Trends Biotechnol. 42(5), 631–647 (2024). https://doi.org/10.1016/j.tibtech.2023.11.00810.1016/j.tibtech.2023.11.008 ↗
7. G.G. Flores-Rojas, B. Gómez-Lazaro, F. López-Saucedo et al., Electrospun scaffolds for tissue engineering: a review. Macromol. 3(3), 524–553 (2023). https://doi.org/10.3390/macromol303003110.3390/macromol3030031 ↗
8. M. Zhang, S. Xu, R. Wang et al., Electrospun nanofiber/hydrogel composite materials and their tissue engineering applications. J. Mater. Sci. Technol. 162, 157–178 (2023). https://doi.org/10.1016/j.jmst.2023.04.01510.1016/j.jmst.2023.04.015 ↗
9. B. Gürbüz, E. Balikci, E.T. Baran, Electrospun scaffolds for heart valve tissue engineering. Explorat Biomater-X 2, 101331 (2025). https://doi.org/10.37349/ebmx.2025.10133110.37349/ebmx.2025.101331 ↗
10. M. Mahmoudi, M.P. Landry, A. Moore, R. Coreas, The protein corona from nanomedicine to environmental science. Nat. Rev. Mater. 8, 422–438 (2023). https://doi.org/10.1038/s41578-023-00552-210.1038/s41578-023-00552-2 ↗
11. B. ÖnalAcet, D. Gül, R.H. Stauber, M. Odabaşı, Ö. Acet, A review for uncovering the “protein-nanoparticle alliance”: implications of the protein corona for biomedical applications. Nanomaterials 14(10), 823 (2024). https://doi.org/10.3390/nano1410082310.3390/nano14100823 ↗
12. B. Özcolak, B. Erenay, S. Odabaş, K.D. Jandt, B. Garipcan, Effects of bone surface topography and chemistry on macrophage polarization. Sci. Rep. 14, 12721 (2024). https://doi.org/10.1038/s41598-024-62484-310.1038/s41598-024-62484-3 ↗
13. A.B. Buya, P. Mahlangu, B.A. Witika, From lab to industrial development of lipid nanocarriers using quality by design approach. Int J Pharmaceut: X 8, 100266 (2024). https://doi.org/10.1016/j.ijpx.2024.10026610.1016/j.ijpx.2024.100266 ↗
14. J.G. Duarte, M.G. Duarte, A.P. Piedade et al., Rethinking pharmaceutical industry with quality by design: application in research, development, manufacturing, and quality assurance. AAPS J. 27, 96 (2025). https://doi.org/10.1208/s12248-025-01079-w10.1208/s12248-025-01079-w ↗
15. X. Zhang, H.W. Chan, Z. Shao, Q. Wang, S. Chow, S.F. Chow, Navigating translational research in nanomedicine: a strategic guide to formulation and manufacturing. Int. J. Pharm. 671, 125202 (2025). https://doi.org/10.1016/j.ijpharm.2025.12520210.1016/j.ijpharm.2025.125202 ↗
16. C. Peng, Editorial: Nanomedicine development and clinical translation. Front. Chem. 12, 1458690 (2024). https://doi.org/10.3389/fchem.2024.145869010.3389/fchem.2024.1458690 ↗
17. H. Azimizonuzi, A. Ghayourvahdat, M.H. Ahmed, R.A. Kareem, A.J. Zrzor, A.S. Mansoor, Z.H. Athab, S. Kalavi, A state-of-the-art review of the recent advances of theranostic liposome hybrid nanoparticles in cancer treatment and diagnosis. Cancer Cell Int. 25(1), 26 (2025). https://doi.org/10.1186/s12935-024-03610-z10.1186/s12935-024-03610-z ↗
18. D.S.R. Khafaga, M.T. El-Morsy, H. Faried, A.H. Diab, S. Shehab, A.M. Saleh, G.A.M. Ali, Metal–organic frameworks in drug delivery: engineering versatile platforms for therapeutic applications. RSC Adv. 14, 30201–30229 (2024). https://doi.org/10.1039/D4RA04441J10.1039/D4RA04441J ↗
19. H.D. Lawson, S.P. Walton, C. Chan, Metal-organic frameworks for drug delivery: a design perspective. ACS Appl. Mater. Interfaces 13(6), 7004–7020 (2021). https://doi.org/10.1021/acsami.1c0108910.1021/acsami.1c01089 ↗
20. A.K. Mehata, M.K. Viswanadh, M.S. Muthu, Theranostics of metal-organic frameworks: image-guided nanomedicine for clinical translation. Nanomedicine (Lond.) 18(8), 695–703 (2023). https://doi.org/10.2217/nnm-2022-027810.2217/nnm-2022-0278 ↗
21. F.D. Duman, R.S. Forgan, Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine. J. Mater. Chem. B 9, 3423–3449 (2021). https://doi.org/10.1039/D1TB00358E10.1039/D1TB00358E ↗
22. Z. Guo, Y. Xiao, W. Wu, M. Zhe, P. Yu, S. Shakya, Z. Li, F. Xing, Metal–organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives. J. Nanobiotechnol. 23, 157 (2025). https://doi.org/10.1186/s12951-025-03252-x10.1186/s12951-025-03252-x ↗
23. D. Menon, D. Fairen-Jimenez, Guiding the rational design of biocompatible metal-organic frameworks for drug delivery. Matter 8(3), 101958 (2025). https://doi.org/10.1016/j.matt.2025.10195810.1016/j.matt.2025.101958 ↗
24. H.D. Cornell, A.T. Sose, S. Ilic, S. Chinnabattigalla, N.E. Lidman, C.M. Oldmixon, X. Yang, S.A. Deshmukh, A.J. Morris, Photoactivated multivariate metal-organic frameworks for on-demand drug release: the role of host-guest interactions. J. Am. Chem. Soc. 147(9), 7423–7432 (2025). https://doi.org/10.1021/jacs.4c1522210.1021/jacs.4c15222 ↗
25. L. Li, R. Hao, J. Qin, J. Song, X. Chen, F. Rao, J. Zhai, Y. Zhao, L. Zhang, J. Xue, Electrospun fibers control drug delivery for tissue regeneration and cancer therapy. Adv. Fiber Mater. 4, 1375–1413 (2022). https://doi.org/10.1007/s42765-022-00198-910.1007/s42765-022-00198-9 ↗
26. R. Jiffrin, S.I. Abd Razak, M.I. Jamaludin, A.S.A. Hamzah, M.A. Mazian, M.A.T. Jaya, M.Z. Nasrullah, M. Majrashi, A. Theyab, A.A. Aldarmahi, Z. Awan, M.M. Abdel-Daim, A.K. Azad, Electrospun nanofiber composites for drug delivery: a review on current progresses. Polymers 14(18), 3725 (2022). https://doi.org/10.3390/polym1418372510.3390/polym14183725 ↗
27. N. Palani, P. Vijayakumar, P. Monisha, S. Ayyadurai, S. Rajadesingu, Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing. J. Nanobiotechnol. 22, 211 (2024). https://doi.org/10.1186/s12951-024-02491-810.1186/s12951-024-02491-8 ↗
28. Z. Xiang, X. Guan, Z. Ma, Q. Shi, M. Panteleev, F.I. Ataullakhanov, Bioactive fibrous scaffolds with programmable release of polypeptides regulate inflammation and extracellular matrix remodeling. Regen. Biomater. 10, rbad010 (2023). https://doi.org/10.1093/rb/rbad01010.1093/rb/rbad010 ↗
29. W. Yi, P. Xiao, X. Liu, Z. Zhao, X. Sun, J. Wang, L. Zhou, G. Wang, H. Cao, D. Wang, Y. Li, Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry. Signal Transduct. Target. Ther. 7, 386 (2022). https://doi.org/10.1038/s41392-022-01250-110.1038/s41392-022-01250-1 ↗
30. R.L. Pinals, L. Chio, F. Ledesma, M.P. Landry, Engineering at the nano-bio interface: harnessing the protein corona towards nanoparticle design and function. Analyst 145, 5090–5112 (2020). https://doi.org/10.1039/D0AN00633E10.1039/D0AN00633E ↗
31. A. Salvati, The biomolecular corona of nanomedicines: effects on nanomedicine outcomes and emerging opportunities. Curr. Opin. Biotechnol. 87, 103101 (2024). https://doi.org/10.1016/j.copbio.2024.10310110.1016/j.copbio.2024.103101 ↗
32. M.J. Mitchell, M.M. Billingsley, R.M. Haley, M.E. Wechsler, N.A. Peppas, R. Langer, Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug Discov. 20, 101–124 (2021). https://doi.org/10.1038/s41573-020-0090-810.1038/s41573-020-0090-8 ↗
33. N. Singh, C. Marets, J. Boudon, N. Millot, L. Saviot, L. Maurizi, In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior? Nanoscale Adv. 3, 1209–1229 (2021). https://doi.org/10.1039/D0NA00863J10.1039/D0NA00863J ↗
34. M. Overchuk, R.A. Weersink, B.C. Wilson, G. Zheng, Photodynamic and photothermal therapies: synergy opportunities for nanomedicine. ACS Nano 17(9), 7979–8003 (2023). https://doi.org/10.1021/acsnano.3c0089110.1021/acsnano.3c00891 ↗
35. Z. Shen, Q. Ma, X. Zhou, G. Zhang, G. Hao, Y. Sun, J. Cao, Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment. NPG Asia Mater. 13, 39 (2021). https://doi.org/10.1038/s41427-021-00303-110.1038/s41427-021-00303-1 ↗
36. H.F. Abed, W.H. Abuwatfa, G.A. Husseini, Redox-responsive drug delivery systems: a chemical perspective. Nanomaterials 12(18), 3183 (2022). https://doi.org/10.3390/nano1218318310.3390/nano12183183 ↗
37. K. Chen, Y. Li, Y. Li, Y. Tan, Y. Liu, W. Pan, G. Tan, Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering. J. Nanobiotechnol. 21, 237 (2023). https://doi.org/10.1186/s12951-023-01987-z10.1186/s12951-023-01987-z ↗
38. J. Li, X. Gao, Y. Wang, T. Xia, Y. Zhao, H. Meng, Precision design of engineered nanomaterials to guide immune systems for disease treatment. Matter 5(4), 1162–1191 (2022). https://doi.org/10.1016/j.matt.2022.03.00510.1016/j.matt.2022.03.005 ↗
39. N. Bian, C. Chu, S. Rung, V. Huangphattarakul, Y. Man, J. Lin, C. Hu, Immunomodulatory biomaterials and emerging analytical techniques for probing the immune micro-environment. Tissue Eng. Regen. Med. 20(1), 11–24 (2022). https://doi.org/10.1007/s13770-022-00491-z10.1007/s13770-022-00491-z ↗
40. H. Amani, M. Alipour, E. Shahriari, J.M. Taboas, Immunomodulatory biomaterials: tailoring surface properties to mitigate foreign body reaction and enhance tissue regeneration. Adv. Healthc. Mater. 13, e2401253 (2024). https://doi.org/10.1002/adhm.20240125310.1002/adhm.202401253 ↗
41. M. Rawal, A. Singh, M.M. Amiji, Quality-by-design concepts to improve nanotechnology-based drug development. Pharm. Res. 36, 153 (2019). https://doi.org/10.1007/s11095-019-2692-610.1007/s11095-019-2692-6 ↗
42. T. Bastogne, Quality-by-design of nanopharmaceuticals — a state of the art. Nanomedicine 13(7), 2151–2157 (2017). https://doi.org/10.1016/j.nano.2017.05.01410.1016/j.nano.2017.05.014 ↗
43. P.D. Fernandes, F.D. Magalhães, R.F. Pereira, A.M. Pinto, Metal-organic frameworks applications in synergistic cancer photo-immunotherapy. Polymers 15, 1490 (2023). https://doi.org/10.3390/polym1506149010.3390/polym15061490 ↗
44. S. Puri, M. Mazza, G. Roy, R.M. England, L. Zhou, S. Nourian, J.A. Subramony, Evolution of nanomedicine formulations for targeted delivery and controlled release. Adv. Drug Deliv. Rev. 200, 114962 (2023). https://doi.org/10.1016/j.addr.2023.11496210.1016/j.addr.2023.114962 ↗
45. R.J. Hickman, P. Bannigan, Z. Bao, A. Aspuru-Guzik, C. Allen, Self-driving laboratories: a paradigm shift in nanomedicine development. Matter 6(4), 1071–1081 (2023). https://doi.org/10.1016/j.matt.2023.02.00710.1016/j.matt.2023.02.007 ↗
46. H. Zhao, Y. Wang, L. Bao, C. Chen, Engineering nano-bio interfaces from nanomaterials to nanomedicines. Acc. Mater. Res. 3(8), 812–823 (2022). https://doi.org/10.1021/accountsmr.2c0007210.1021/accountsmr.2c00072 ↗
47. S. Waheed, Z. Li, F. Zhang, A. Chiarini, U. Armato, J. Wu, Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery. J. Nanobiotechnol. 20, 395 (2022). https://doi.org/10.1186/s12951-022-01605-410.1186/s12951-022-01605-4 ↗
48. M. Barbalinardo, J. Bertacchini, L. Bergamini, M.S. Magarò, L. Ortolani, A. Sanson, C. Palumbo, M. Cavallini, D. Gentili, Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles. Nanoscale 13, 14119–14129 (2021). https://doi.org/10.1039/D0NR08259G10.1039/D0NR08259G ↗
49. T. Cedervall, I. Lynch, S. Lindman, T. Berggård, E. Thulin, H. Nilsson, K.A. Dawson, S. Linse, Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc. Natl. Acad. Sci. U. S. A. 104(7), 2050–2055 (2007). https://doi.org/10.1073/pnas.060858210410.1073/pnas.0608582104 ↗
50. T. Zhao, M. Ren, J. Shi, H. Wang, J. Bai, W. Du, B. Xiang, Engineering the protein corona: strategies, effects, and future directions in nanoparticle therapeutics. Biomed. Pharmacother. 175, 116627 (2024). https://doi.org/10.1016/j.biopha.2024.11662710.1016/j.biopha.2024.116627 ↗
51. H. Zhang, J. Wang, R. Han, B. Sun, C. Luo, Bioorthogonal chemistry-driven anticancer nanotherapeutics. Trends Chem. 5(9), 697–710 (2023). https://doi.org/10.1016/j.trechm.2023.05.00610.1016/j.trechm.2023.05.006 ↗
52. K. Li, L. Lv, D. Shao, Y. Xie, Y. Cao, X. Zheng, Engineering nanopatterned structures to orchestrate macrophage phenotype by cell shape. J. Funct. Biomater. 13(1), 31 (2022). https://doi.org/10.3390/jfb1301003110.3390/jfb13010031 ↗
53. P.K. Chocholata, J. Dvorakova, V. Babuska et al., Biomaterial strategies of macrophage behaviour in bone regeneration. Regen. Eng. Transl. Med. (2025). https://doi.org/10.1007/s40883-025-00443-810.1007/s40883-025-00443-8 ↗
54. T. Yang, Z. Fang, J. Zhang, S. Zheng, Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review. Front. Bioeng. Biotechnol. 13, 1640560 (2025). https://doi.org/10.3389/fbioe.2025.164056010.3389/fbioe.2025.1640560 ↗
55. H. Mitwalli, R. Alsahafi, A.A. Balhaddad, M.D. Weir, H.H.K. Xu, M.A.S. Melo, Emerging contact-killing antibacterial strategies for developing anti-biofilm dental polymeric restorative materials. Bioengineering 7(3), 83 (2020). https://doi.org/10.3390/bioengineering703008310.3390/bioengineering7030083 ↗
56. M. Fatima, W.H. Almalki, T. Khan, A. Sahebkar, P. Kesharwani, Harnessing the power of stimuli-responsive nanoparticles as an effective therapeutic drug delivery system. Adv. Mater. 36(24), 2312939 (2024). https://doi.org/10.1002/adma.20231293910.1002/adma.202312939 ↗
57. U.S. Food and Drug Administration. Roadmap to Reducing Animal Testing in Preclinical Safety Studies. FDA White Paper; 2025. Available at: https://www.fda.gov/media/186092/download (accessed 14 September 2025).
58. U.S. Food and Drug Administration. Use of International Standard ISO 10993–1, “Biological Evaluation of Medical Devices—Part 1: Evaluation and Testing Within a Risk Management Process.” Guidance for Industry and FDA Staff; 2023. Available at: https://www.fda.gov/media/142959/download (accessed 12 October 2025).
59. ASTM International. ASTM E3427–24: Standard Guide for Measuring Intensity, Polydispersity, Size, Zeta Potential, Molecular Weight, and Concentration of Nanoparticles in Liquid Suspension Using Laser-Amplified Detection/Power Spectrum Analysis (LAD/PSA). West Conshohocken, PA: ASTM; 2024. https://store.astm.org/e3427-24.html
60. ISO. ISO 10993–1:2018 — Biological evaluation of medical devices — Part 1: Evaluation and testing within a risk management process. ISO; 2018. Available at: https://www.iso.org/standard/68936.html (accessed 12 October 2025).
61. A.A. Ashkarran, H. Gharibi, S.M. Modaresi, A.A. Saei, M. Mahmoudi, Standardizing protein corona characterization in nanomedicine: a multicenter study to enhance reproducibility and data homogeneity. Nano Lett. 24(32), 9874–9881 (2024). https://doi.org/10.1021/acs.nanolett.4c0207610.1021/acs.nanolett.4c02076 ↗
62. C. Camacho Vieira, L. Peltonen, A.P. Karttunen, A.J. Ribeiro, Is it advantageous to use quality by design (QbD) to develop nanoparticle-based dosage forms for parenteral drug administration? Int. J. Pharm. 657, 124163 (2024). https://doi.org/10.1016/j.ijpharm.2024.12416310.1016/j.ijpharm.2024.124163 ↗
63. S. Nagpal, T. Palaniappan, J.-W. Wang, M.G. Wacker, Revisiting nanomedicine design strategies for follow-on products: a model-informed approach to optimize performance. J. Control. Release 376, 1251–1270 (2024). https://doi.org/10.1016/j.jconrel.2024.11.00410.1016/j.jconrel.2024.11.004 ↗
64. Y. Wu, L. Yin, S. Xu et al., Room-temperature synthesis of a Zr–UiO-66 metal–organic framework via mechanochemical pretreatment. Dalton Trans. (2024). https://doi.org/10.1039/D4DT01671H10.1039/D4DT01671H ↗
65. V.S. Chernonosova, I.E. Kuzmin, I.K. Shundrina et al., Effect of sterilization methods on electrospun scaffolds produced from a polyurethane–gelatin blend. J. Funct. Biomater. 14(2), 70 (2023). https://doi.org/10.3390/jfb1402007010.3390/jfb14020070 ↗
66. U.E. Ewii, A.A. Attama, E.O. Olorunsola, A.L. Onugwu, F.U. Nwakpa, C. Anyiam, C. Chijioke, T. Ogbulie, Nanoparticles for drug delivery: insight into in vitro and in vivo drug release from nanomedicines. Nano TransMed 4, 100083 (2025). https://doi.org/10.1016/j.ntm.2025.10008310.1016/j.ntm.2025.100083 ↗
67. U.S. Government Accountability Office. Human Organ-on-a-Chip, Technologies Offer Benefits Over Animal Testing but Challenges Limit Wider Adoption; 2025. Available at: https://www.gao.gov/assets/gao-25-107335.pdf (accessed 12 October 2025).
68. N. Desai, D. Rana, M. Patel, N. Bajwa, R. Prasad, L.K. Vora, Nanoparticle therapeutics in clinical perspective: classification, marketed products, and regulatory landscape. Small (2025). https://doi.org/10.1002/smll.20250231510.1002/smll.202502315 ↗
69. C.L. Mustoe, A.J. Turner, S.J. Urwin, I. Houson, H. Feilden, D. Markl et al., Quality by digital design to accelerate sustainable medicines development. Int. J. Pharm. 681, 125625 (2025). https://doi.org/10.1016/j.ijpharm.2025.12562510.1016/j.ijpharm.2025.125625 ↗
70. C.L. Mustoe, A.J. Turner, S.J. Urwin et al., Quality by digital design to accelerate sustainable medicines development. Int. J. Pharm. 681, 125625 (2025). https://doi.org/10.1016/j.ijpharm.2025.12562510.1016/j.ijpharm.2025.125625 ↗
71. Z. Wei, S. Zhuo, Y. Zhang, Wu. Lianlian, X. Gao, S. He, X. Bo, W. Zhou, Machine learning reshapes the paradigm of nanomedicine research. Acta Pharmaceutica Sinica B (2025). https://doi.org/10.1016/j.apsb.2025.05.01410.1016/j.apsb.2025.05.014 ↗
72. Q. Wang, Y. Liu, C. Li, B. Xu, S. Xu, B. Liu, Machine learning-enhanced nanoparticle design for precision cancer drug delivery. Adv. Sci. 12(00), 2303138 (2025). https://doi.org/10.1002/advs.20250313810.1002/advs.202503138 ↗
73. Z. Ban, P. Yuan, F. Yu, T. Peng, Q. Zhou, X. Hu, Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles. Proc. Natl. Acad. Sci. U. S. A. 117, 10492–10499 (2020). https://doi.org/10.1073/pnas.191975511710.1073/pnas.1919755117 ↗
74. S. Han, J. Wu, Artificial intelligence (AI) meets biomaterials and biomedicine. Smart Mater. Med. 5(2), 251–255 (2024). https://doi.org/10.1016/j.smaim.2024.03.00110.1016/j.smaim.2024.03.001 ↗
75. U. Bozuyuk, P. Wrede, E. Yıldız, M. Sitti, Roadmap for clinical translation of mobile microrobotics. Adv. Mater. 36(23), 2311462 (2024). https://doi.org/10.1002/adma.20231146210.1002/adma.202311462 ↗
76. H. Han, X. Ma, W. Deng, J. Zhang, S. Tang, O.S. Pak, L. Zhu, E. Criado-Hidalgo, C. Gong et al., Imaging-guided bioresorbable acoustic hydrogel microrobots. Sci. Robot. 9(97), eadp3593 (2024). https://doi.org/10.1126/scirobotics.adp359310.1126/scirobotics.adp3593 ↗
77. Y. Zou, Y. Liu, Y. Li, L. Yang, Y. Liu, K. He, Y. Xiang, J. Ouyang, P. Li et al., Magnetically actuated multimaterial fiberbot for precise minimally invasive knee laser surgery. Sci. Adv. 11(35), adt1809 (2025). https://doi.org/10.1126/sciadv.adt180910.1126/sciadv.adt1809 ↗
78. Y. Hong, W. Ma, M. Wang, H. Wang, Advances in programmable DNA nanostructures enabling stimuli-responsive drug delivery and multimodal biosensing. RSC Chem. Biol. 6(9), 1366–1385 (2025). https://doi.org/10.1039/d5cb00057b10.1039/d5cb00057b ↗
79. H. Abdollahzadeh, T.L. Peeples, M. Shahcheraghi, DNA nanotechnology in oligonucleotide drug delivery systems: prospects for bio-nanorobots in cancer treatment. Adv. Drug Deliv. Rev. 225, 115673 (2025). https://doi.org/10.1016/j.addr.2025.11567310.1016/j.addr.2025.115673 ↗
80. S. Sun, J.-D. Wen, Q.-R. Xiao, X.-L. Qiang, X.-L. Shi, Molecular logic gates based on programmable self-assembly of DNA origami triangles for the detection of nucleic acid molecules. Sci. Rep. 15(1), 29178 (2025). https://doi.org/10.1038/s41598-025-15119-010.1038/s41598-025-15119-0 ↗
81. J. Gołąbek, M. Strankowski, A review of recent advances in human-motion energy harvesting nanogenerators, self-powering smart sensors and self-charging electronics. Sensors 24(4), 1069 (2024). https://doi.org/10.3390/s2404106910.3390/s24041069 ↗
82. J.-H. Kim, H. Yoon, S. Viswanath, C. Dagdeviren, Conformable piezoelectric devices and systems for advanced wearable and implantable biomedical applications. Annu. Rev. Biomed. Eng. 27(1), 255–282 (2025). https://doi.org/10.1146/annurev-bioeng-020524-12143810.1146/annurev-bioeng-020524-121438 ↗
83. A. Khan, R. Joshi, M.K. Sharma, A. Ganguly, P. Parashar, T.-W. Wang, S. Lee, F.-C. Kao, Z.-H. Lin, Piezoelectric and triboelectric nanogenerators: promising technologies for self-powered implantable biomedical devices. Nano Energy 119, 109051 (2024). https://doi.org/10.1016/j.nanoen.2023.10905110.1016/j.nanoen.2023.109051 ↗
84. S. Chen, Z. Zhou, K. Hou, X. Wu, Q. He, C.G. Tang, T. Li, X. Zhang, J. Jie, Z. Gao, N. Mathews, W.L. Leong, Artificial organic afferent nerves enable closed-loop tactile feedback for intelligent robots. Nat. Commun. 15, 7056 (2024). https://doi.org/10.1038/s41467-024-51403-910.1038/s41467-024-51403-9 ↗
85. S. Zhou, Y. Li, Q. Wang, Z. Lyu, Integrated actuation and sensing: toward intelligent soft robots. Cyborg Bionic Syst. 5, 0105 (2024). https://doi.org/10.34133/cbsystems.010510.34133/cbsystems.0105 ↗