Synergistic interaction of copper MOF and ciprofloxacin for enhanced antibacterial activity: A novel approach in biomedical materials and drug design strategy
Source abstract
Abstract
In this study, Ni, Cu, and Zn-based metal–organic frameworks (MOFs) were synthesized and characterized, followed by biological evaluation against selected bacterial and fungal strains. Minimum Inhibitory Concentration study results highlighted the superior antimicrobial efficiency of Cu-MOF with as low as MIC values of 128 µg/ml against the bacterial strains ofEscherichia coli(E. coli)and Staphylococcus aureus (S. aureus). To study synergistic effect of the most potential candidate Cu-MOF with the proven antibiotic ciprofloxacin. The interaction and synergistic effect between the Cu-MOF and ciprofloxacin was confirmed by the Fractional inhibitory concentration index (FICI) values of 0.37 and 0.31 against theS. aureus and E. colibacterial strains and the low amount needed of Cu-MOF 16 µg/ml and 8 µg/ml with the combination of 1 µg/ml and 0.5 µg/ml of the ciprofloxacin respectively. These findings advocate the broader applications of synergistic strategies and novel approaches in biomedical materials to the fight against bacterial infections.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Advanced Nanomaterials in Catalysis · X-ray Diffraction in Crystallography
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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