GQDs-ε-PL and GQDs-ε-PL-based self-healing hydrogel: Synthesis, characterization and in vitro chemo-photothermal combined antibacterial
Source abstract
Abstract
Surface amino-rich GQDs-ε-PL is prepared by changing the addition amount of ε-PL. Then, GQDs-ε-PL@4-arm PEG-BA/QCS hydrogels (GQDs-ε-PL@Gel) are synthesized through dynamic imine bonds cross-linking. The sol can transform quickly to gel and the gelation time can be controlled by adjusting the specific gravity of the input raw materials to water. FT-IR and thermogravimetric analyses indicate the successful synthesis of GQDs-ε-PL and GQDs-ε-PL@Gel. The microstructure observation reveals that GQDs-ε-PL has a sheet-like structure with an average size of 65 nm, while GQDs-ε-PL@Gel has a porous network structure. Both GQDs-ε-PL and GQDs-ε-PL@Gel have good fluorescence stability, photothermal and cytocompatibility, and display better antibacterial effect againstEscherichia coli,Staphylococcus aureusandPseudomonas aeruginosathrough chemical and photothermal synergistic sterilization. More importantly, GQDs-ε-PL@Gel can repeatedly self-heal after being damaged, which is more beneficial to provide an effective wound closure environment for wounds and to be used as wound dressings.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoplatforms for cancer theranostics · Carbon and Quantum Dots Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (32)
Show source-provided references
1. T.N. Pham, P. Loupias, A. Dassonville-Klimpt, P. Sonnet, Drug delivery systems designed to overcome antimicrobial resistance. Med. Res. Rev. 39(6), 2343 (2019)10.1002/med.21588 ↗
2. Y. Cheng, H. Cheng, C. Jiang, X. Qiu, K. Wang, W. Huan, A. Yuan, J. Wu, Y. Hu, Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy. Nat. Commun. 6, 8785 (2015)10.1038/ncomms9785 ↗
3. J. Sun, L. Song, Y. Fan, L. Tian, S. Luan, S. Niu, L. Ren, W. Ming, J. Zhao, Synergistic photodynamic and photothermal antibacterial nanocomposite membrane triggered by single NIR light source. ACS Appl. Mater. Interfaces 11(30), 26581 (2019)10.1021/acsami.9b07037 ↗
4. X. Cui, S. Xu, X. Wang, C. Chen, The nano-bio interaction and biomedical applications of carbon nanomaterials. Carbon 138, 436 (2018)10.1016/j.carbon.2018.07.069 ↗
5. J. Wang, J. Zhang, K. Liu, J. He, Y. Zhang, S. Chen, G. Ma, Y. Cui, L. Wang, D. Gao, Synthesis of gold nanoflowers stabilized with amphiphilic daptomycin for enhanced photothermal antitumor and antibacterial effects. Int. J. Pharm. 580, 119231 (2020)10.1016/j.ijpharm.2020.119231 ↗
6. F. Peng, F. Zhao, L. Shan, R. Li, S. Jiang, P. Zhang, Black phosphorus nanosheets-based platform for targeted chemo-photothermal synergistic cancer therapy. Colloids Surf. B 198, 111467 (2021)10.1016/j.colsurfb.2020.111467 ↗
7. X. Xu, X. Liu, L. Tan, Z. Cui, X. Yang, S. Zhu, Z. Li, X. Yuan, Y. Zheng, K.W.K. Yeung, P.K. Chu, S. Wu, Controlled-temperature photothermal and oxidative bacteria killing and acceleration of wound healing by polydopamine-assisted Au-hydroxyapatite nanorods. Acta Biomater. 77, 352 (2018)10.1016/j.actbio.2018.07.030 ↗
8. M.C. Wu, A.R. Deokar, J.H. Liao, P.Y. Shih, Y.C. Ling, Graphene-based photothermal agent for rapid and effective killing of bacteria. ACS Nano 7(2), 1281 (2013)10.1021/nn304782d ↗
9. M.R. Detty, S.L. Gibson, S.J. Wagner, Current clinical and preclinical photosensitizers for use in photodynamic therapy. J. Med. Chem. 47(16), 3897 (2004)10.1021/jm040074b ↗
10. Z. Zhu, J. Ma, Z. Wang, C. Mu, Z. Fan, L. Du, Y. Bai, L. Fan, H. Yan, D.L. Phillips, S. Yang, Efficiency enhancement of perovskite solar cells through fast electron extraction: the role of graphene quantum dots. J. Am. Chem. Soc. 136(10), 3760 (2014)10.1021/ja4132246 ↗
11. Z. Zeng, S. Chen, T.T.Y. Tan, F.-X. Xiao, Graphene quantum dots (GQDs) and its derivatives for multifarious photocatalysis and photoelectrocatalysis. Catal. Today 315, 171 (2018)10.1016/j.cattod.2018.01.005 ↗
12. Y. Lei, J. Hu, Z. Zhang, Z. Ouyang, Z. Jiang, Y. Lin, Photoelectric properties of SnO2 decorated by graphene quantum dots. Mater. Sci. Semicond. Process. 102, 104582 (2019)10.1016/j.mssp.2019.06.017 ↗
13. L. Zhang, L. He, Q. Wang, Q. Tang, F. Liu, Theoretical and experimental studies of a novel electrochemical sensor based on molecularly imprinted polymer and GQDs-PtNPs nanocomposite. Microchem. J. 158, 105196 (2020)10.1016/j.microc.2020.105196 ↗
14. Y. Pang, R. Zhao, Y. Lu, J. Liu, X. Dong, F. Xi, Facile preparation of N-doped graphene quantum dots as quick-dry fluorescent ink for anti-counterfeiting. New J. Chem. 42(20), 17091 (2018)10.1039/C8NJ03375G ↗
15. S. Campuzano, P. Yanez-Sedeno, J.M. Pingarron, Carbon dots and graphene quantum dots in electrochemical biosensing. Nanomaterials (Basel) 9(4), 634 (2019)10.3390/nano9040634 ↗
16. S. Chung, R.A. Revia, M. Zhang, Graphene quantum dots and their applications in bioimaging, biosensing, and therapy. Adv Mater. 33(22), e1904362 (2021)10.1002/adma.201904362 ↗
17. S.F. Seyedpour, A. Rahimpour, A.A. Shamsabadi, M. Soroush, Improved performance and antifouling properties of thin-film composite polyamide membranes modified with nano-sized bactericidal graphene quantum dots for forward osmosis. Chem. Eng. Res. Des. 139, 321 (2018)10.1016/j.cherd.2018.09.041 ↗
18. C. Zhao, X. Song, Y. Liu, Y. Fu, L. Ye, N. Wang, F. Wang, L. Li, M. Mohammadniaei, M. Zhang, Q. Zhang, J. Liu, Synthesis of graphene quantum dots and their applications in drug delivery. J. Nanobiotechnol. 18(1), 142 (2020)10.1186/s12951-020-00698-z ↗
19. Y. Dong, C.X. Guo, Y. Chi, C.M. Li, Reply to comment on “one-step and high yield simultaneous preparation of single-and multi-layer graphene quantum dots from CX-72 carbon black.” J. Mater. Chem. 22(40), 21777 (2012)10.1039/c2jm34130a ↗
20. A.E. Stoica, C. Chircov, A.M. Grumezescu, Hydrogel dressings for the treatment of burn wounds: an up-to-date overview. Materials (Basel) 13(12), 2853 (2020)10.3390/ma13122853 ↗
21. H. Cheng, Z. Shi, K. Yue, X. Huang, Y. Xu, C. Gao, Z. Yao, Y.S. Zhang, J. Wang, Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities. Acta Biomater. 124, 219 (2021)10.1016/j.actbio.2021.02.002 ↗
22. B. Zhang, Y. Lv, C. Yu, W. Zhang, S. Song, Y. Li, Y. Chong, J. Huang, Z. Zhang, Au-Pt nanozyme-based multifunctional hydrogel dressing for diabetic wound healing. Biomater. Adv. 137, 212869 (2022)10.1016/j.bioadv.2022.212869 ↗
23. M.T. Khorasani, A. Joorabloo, H. Adeli, P.B. Milan, M. Amoupour, Enhanced antimicrobial and full-thickness wound healing efficiency of hydrogels loaded with heparinized ZnO nanoparticles: in vitro and in vivo evaluation. Int. J. Biol. Macromol. 166, 200 (2021)10.1016/j.ijbiomac.2020.10.142 ↗
24. Y. Tu, N. Chen, C. Li, H. Liu, R. Zhu, S. Chen, Q. Xiao, J. Liu, S. Ramakrishna, L. He, Advances in injectable self-healing biomedical hydrogels. Acta Biomater. 90, 1 (2019)10.1016/j.actbio.2019.03.057 ↗
25. T. Ma, X. Zhai, Y. Huang, M. Zhang, X. Zhao, Y. Du, C. Yan, A smart nanoplatform with photothermal antibacterial capability and antioxidant activity for chronic wound healing. Adv. Healthc. Mater. 10(13), e2100033 (2021)10.1002/adhm.202100033 ↗
26. D. Zhang, F. Peng, J. Tan, Y. Zhang, F. Wang, J. Xie, R. Xu, H. Du, S. Qian, Y. Qiao, M. Li, X. Liu, Self-assembled ferric oxyhydroxide nanosheet on PEO-coated magnesium alloy with photocatalytic/photothermal antibacterial and enhanced osteogenesis activities. Chem. Eng. J. 437, 135257 (2022)10.1016/j.cej.2022.135257 ↗
27. R. Ye, H. Xu, C. Wan, S. Peng, L. Wang, H. Xu, Z.P. Aguilar, Y. Xiong, Z. Zeng, H. Wei, Antibacterial activity and mechanism of action of epsilon-poly-L-lysine. Biochem. Biophys. Res. Commun. 439(1), 148 (2013)10.1016/j.bbrc.2013.08.001 ↗
28. S. Rao, M. Sun, Y. Hu, X. Zheng, Z. Yang, X. Jiao, ε-Polylysine-coated liposomes loaded with a β-CD inclusion complex loaded with carvacrol: Preparation, characterization, and antibacterial activities. LWT 146, 111422 (2021)10.1016/j.lwt.2021.111422 ↗
29. A. Gonsho, K. Irie, H. Susaki, H. Iwasawa, S. Okuno, T. Sugawara, Tissue-targeting ability of saccharide-poly(L-lysine) conjugates. Biol. Pharm. Bull. 17(2), 275 (1994)10.1248/bpb.17.275 ↗
30. S.S. Wang, P.L. Hsieh, P.S. Chen, Y.T. Chen, J.S. Jan, Genipin-cross-linked poly(L-lysine)-based hydrogels: synthesis, characterization, and drug encapsulation. Colloids Surf. B 111, 423 (2013)10.1016/j.colsurfb.2013.06.028 ↗
31. X. Li, D. Fan, X. Ma, C. Zhu, Y. Luo, B. Liu, L. Chen, A novel injectable pH/temperature sensitive CS-HLC/β-GP hydrogel: the gelation mechanism and its properties. Soft Mater. 12(1), 1 (2014)10.1080/1539445X.2011.584269 ↗
32. Y. Fan, T. Saito, A. Isogai, Individual chitin nano-whiskers prepared from partially deacetylated α-chitin by fibril surface cationization. Carbohydr. Polym. 79(4), 1046 (2010)10.1016/j.carbpol.2009.10.044 ↗