journal article·2023-09-14

Ceramic nanomaterials: Preparation and applications in osteoporosis and bone tissue regeneration

Anish John, Apurva M. Shetty, Kshema Salian, Samantha Neha Sequeria, P. R. Sumukh, Dewi Sukmawati, Gowtham Menon, Shajan Abraham, Jayachandran Venkatesan, V. Anoop Narayanan

Journal of Materials Research· Volume 38· Issue 17
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Abstract

The lives and well-being of individuals have been greatly impacted by bone defects brought on by trauma, tumors, genetic disorders, osteoporosis, etc. Also, in the past few decades, the worlds aging population has increased the need for nanotechnology to treat trauma-related bone diseases and tissue damage. To successfully imitate the structures seen in naturally occurring systems, nanoengineered systems can now do so. Hence, much focus and effort have been spent in the last decade on nanotechnology, especially nanomaterials. Ceramic nanomaterials have been widely used in tissue repair and engineering due to their high biocompatibility and reactivity. This review aims to identify and discuss the properties, applications in osteoporosis and bone tissue regeneration, mechanism of action, biocompatibility, drawbacks, and future scopes of a few ceramic nanomaterials, i.e., calcium phosphate, hydroxyapatite, mesoporous silica, and bioactive glass.Graphical AbstractImages reproduced from sources: Adobe Stock, Wikimedia commons, Vecteezy, and iStock under creative commons (with free-to-reuse permission for noncommercial purposes).
Source: expertdata · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Facial Trauma and Fracture Management · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (100+)

Show source-provided references
1. I. Akkawi, H. Zmerly, Osteoporosis: current concepts. Joints 6(02), 122 (2018)10.1055/s-0038-1660790 ↗
2. W.F. Lems, H.G. Raterman, Critical issues and current challenges in osteoporosis and fracture prevention. An overview of unmet needs. Ther. Adv. Musculoskelet. Dis. 9(12), 299–300 (2017)10.1177/1759720X17732562 ↗
3. M.A. Clynes, N.C. Harvey, E.M. Curtis, N.R. Fuggle, E.M. Dennison, C. Cooper, The epidemiology of osteoporosis. Br. Med. Bull. 133(1), 105 (2020)
4. O. Riester, M. Borgolte, R. Csuk, H.-P. Deigner, Challenges in bone tissue regeneration: stem cell therapy, biofunctionality and antimicrobial properties of novel materials and its evolution. Int. J. Mol. Sci. 22(1), 192 (2020)10.3390/ijms22010192 ↗
5. R. Dimitriou, E. Jones, D. McGonagle, P.V. Giannoudis, Bone regeneration: current concepts and future directions. BMC Med. 9(1), 1 (2011)10.1186/1741-7015-9-66 ↗
6. D. Iannazzo, A. Pistone, M. Salamò, S. Galvagno, Hybrid ceramic/polymer composites for bone tissue regeneration, in Hybrid Polymer Composite Materials (Elsevier, Amsterdam, 2017), p. 12510.1016/B978-0-08-100789-1.00006-X ↗
7. K. Szurkowska, P. Kazimierczak, J. Kolmas, Mg, Si–Co-substituted hydroxyapatite/alginate composite beads loaded with raloxifene for potential use in bone tissue regeneration. Int. J. Mol. Sci. 22(6), 2933 (2021)10.3390/ijms22062933 ↗
8. C. Buzea, I. Pacheco, Nanomaterials and their classification, in EMR/ESR/EPR Spectroscopy for Characterization of Nanomaterials (Springer, New Delhi, 2017), p. 310.1007/978-81-322-3655-9_1 ↗
9. R. Foulkes, E. Man, J. Thind, S. Yeung, A. Joy, C. Hoskins, The regulation of nanomaterials and nanomedicines for clinical application: current and future perspectives. Biomater. Sci. 8(17), 4653 (2020)10.1039/D0BM00558D ↗
10. S. Balasubramanian, B. Gurumurthy, A. Balasubramanian, Biomedical applications of ceramic nanomaterials: a review. Int. J. Pharm. Sci. Res. 8(12), 4950 (2017)
11. N. Ambiga, Selection and creation of nano particles using artificial intelligence. Int. J. Manag. IT Eng. 8(9), 211 (2018)
12. J. Jeong, J.H. Kim, J.H. Shim, N.S. Hwang, C.Y. Heo, Bioactive calcium phosphate materials and applications in bone regeneration. Biomater. Res. 23(1), 1 (2019)10.1186/s40824-018-0149-3 ↗
13. L. Zhao, J. Li, L. Zhang, Y. Wang, J. Wang, B. Gu, J. Chen, T. Hao, C. Wang, N. Wen, Preparation and characterization of calcium phosphate/pectin scaffolds for bone tissue engineering. RSC Adv. 6(67), 62071 (2016)10.1039/C6RA07800A ↗
14. R. Reck, S. Störkel, A. Meyer, Bioactive glass-ceramics in middle ear surgery. An 8-year review. Ann. N. Y. Acad. Sci. 523, 100–101 (1988)10.1111/j.1749-6632.1988.tb38504.x ↗
15. M. Tahriri, R. Bader, W. Yao, S. Dehghani, K. Khoshroo, M. Rasoulianboroujeni, L. Tayebi, Bioactive glasses and calcium phosphates, in Biomaterials for Oral and Dental Tissue Engineering (Elsevier, Amsterdam, 2017), p. 710.1016/B978-0-08-100961-1.00002-5 ↗
16. A. Khojasteh, F. Fahimipour, M.B. Eslaminejad, M. Jafarian, S. Jahangir, F. Bastami, M. Tahriri, A. Karkhaneh, L. Tayebi, Development of PLGA-coated β-TCP scaffolds containing VEGF for bone tissue engineering. Mater. Sci. Eng. C 69, 780 (2016)10.1016/j.msec.2016.07.011 ↗
17. J.R. Popp, K.E. Laflin, B.J. Love, A.S. Goldstein, Fabrication and characterization of poly (lactic-co-glycolic acid) microsphere/amorphous calcium phosphate scaffolds. J. Tissue Eng. Regen. Med. 6(1), 12 (2012)10.1002/term.390 ↗
18. S. Bansal, V. Chauhan, S. Sharma, R. Maheshwari, A. Juyal, S. Raghuvanshi, Evaluation of hydroxyapatite and beta-tricalcium phosphate mixed with bone marrow aspirate as a bone graft substitute for posterolateral spinal fusion. Indian J. Orthopaed. 43(3), 234 (2009)10.4103/0019-5413.49387 ↗
19. I. Kulinets, Biomaterials and their applications in medicine, in Regulatory Affairs for Biomaterials and Medical Devices (Elsevier, Amsterdam, 2015), p. 110.1533/9780857099204.1 ↗
20. T.J. Levingstone, S. Herbaj, N.J. Dunne, Calcium phosphate nanoparticles for therapeutic applications in bone regeneration. Nanomaterials 9(11), 1570 (2019)10.3390/nano9111570 ↗
21. L. Schröter, F. Kaiser, S. Stein, U. Gbureck, A. Ignatius, Biological and mechanical performance and degradation characteristics of calcium phosphate cements in large animals and humans. Acta Biomater. 117, 1 (2020)10.1016/j.actbio.2020.09.031 ↗
22. X. Lin, J. Chen, Y. Liao, J.L. Pathak, H. Li, Y. Liu, Biomimetic calcium phosphate coating as a drug delivery vehicle for bone tissue engineering: a mini-review. Coatings 10(11), 1118 (2020)10.3390/coatings10111118 ↗
23. N.M. Pu’ad, P. Koshy, H. Abdullah, M. Idris, T. Lee, Syntheses of hydroxyapatite from natural sources. Heliyon 5(5), e01588 (2019)10.1016/j.heliyon.2019.e01588 ↗
24. S. Agrawal, R. Srivastava, Osteoinductive and osteoconductive biomaterials, in Racing for the Surface (Springer, Cham, 2020), p. 35510.1007/978-3-030-34471-9_15 ↗
25. G. Fernandez de Grado, L. Keller, Y. Idoux-Gillet, Q. Wagner, A.-M. Musset, N. Benkirane-Jessel, F. Bornert, D. Offner, Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management. J. Tissue Eng. 9, 2041731418776819 (2018)10.1177/2041731418776819 ↗
26. M.U. Munir, S. Salman, A. Ihsan, T. Elsaman, Synthesis, characterization, functionalization and bio-applications of hydroxyapatite nanomaterials: an overview. International Journal of Nanomedicine. 17, 1903–1925 (2022)10.2147/IJN.S360670 ↗
27. C. Guo, J. Xue, Y. Dong, Fabrication and characterization of hydroxyapatite nanomaterial dual deposited with nano silver and zinc oxide. Mater. Lett. 219, 182 (2018)10.1016/j.matlet.2018.02.045 ↗
28. M. Barry, H. Pearce, L. Cross, M. Tatullo, A.K. Gaharwar, Advances in Nanotechnology for the Treatment of Osteoporosis. Curr. Osteoporos. Rep. 14, 87 (2016)10.1007/s11914-016-0306-3 ↗
29. S. Mehnath, M. Jeyaraj, Hydroxyapatite-based nanomaterials for bone tissue regeneration, in Functional Nanomaterials for Regenerative Tissue Medicines, (CRC Press, Boca Raton, 2021), p. 19510.1201/9781003140108-9 ↗
30. A.L.C. Maia, C.H. Cavalcante, M.G. de Souza, C.A. Ferreira, D. Rubello, S. Chondrogiannis, V.N. Cardoso, G.A. Ramaldes, A.L. de Barros, D.C. Soares, Hydroxyapatite nanoparticles: preparation, characterization, and evaluation of their potential use in bone targeting: an animal study. Nucl. Med. Commun. 37(7), 775 (2016)10.1097/MNM.0000000000000510 ↗
31. M. Sadat-Shojai, M.-T. Khorasani, E. Dinpanah-Khoshdargi, A. Jamshidi, Synthesis methods for nanosized hydroxyapatite with diverse structures. Acta Biomater. 9(8), 7591 (2013)10.1016/j.actbio.2013.04.012 ↗
32. L. Stipniece, V. Stepanova, I. Narkevica, K. Salma-Ancane, A.R. Boyd, Comparative study of surface properties of Mg-substituted hydroxyapatite bioceramic microspheres. J. Eur. Ceram. Soc. 38(2), 761 (2018)10.1016/j.jeurceramsoc.2017.09.026 ↗
33. A. Pal, S. Maity, S. Chabri, S. Bera, A.R. Chowdhury, M. Das, A. Sinha, Mechanochemical synthesis of nanocrystalline hydroxyapatite from Mercenaria clam shells and phosphoric acid. Biomed. Phys. Eng. Express 3(1), 015010 (2017)10.1088/2057-1976/aa54f5 ↗
34. A. Pal, S. Paul, A.R. Choudhury, V.K. Balla, M. Das, A. Sinha, Synthesis of hydroxyapatite from Lates calcarifer fish bone for biomedical applications. Mater. Lett. 203, 89 (2017)10.1016/j.matlet.2017.05.103 ↗
35. R.S. Al-Hamdan, B. Almutairi, H.F. Kattan, S. Alresayes, T. Abduljabbar, F. Vohra, Assessment of hydroxyapatite nanospheres incorporated dentin adhesive. A SEM/EDX, micro-raman, microtensile and micro-indentation study. Coatings 10(12), 1181–82 (2020)10.3390/coatings10121181 ↗
36. M. Manzano, M. Vallet-Regí, Mesoporous silica nanoparticles for drug delivery. Adv. Funct. Mater. 30(2), 1902634 (2020)10.1002/adfm.201902634 ↗
37. X. Lyu, X. Wu, Y. Liu, W. Huang, B. Lee, T. Li, Synthesis and characterization of mesoporous silica nanoparticles loaded with Pt catalysts. Catalysts 12(2), 183 (2022)10.3390/catal12020183 ↗
38. D. Das, Y. Yang, J.S. O’Brien, D. Breznan, S. Nimesh, S. Bernatchez, M. Hill, A. Sayari, R. Vincent, P. Kumarathasan, Synthesis and physicochemical characterization of mesoporous SiO2 nanoparticles. J. Nanomater. 2014, 62 (2014)10.1155/2014/176015 ↗
39. M. Gisbert-Garzarán, M. Manzano, M. Vallet-Regí, Mesoporous silica nanoparticles for the treatment of complex bone diseases: bone cancer, bone infection and osteoporosis. Pharmaceutics. 12(1), 83 (2020)10.3390/pharmaceutics12010083 ↗
40. E. Bindini, Z. Chehadi, M. Faustini, P.-A. Albouy, D. Grosso, A. Cattoni, C. Chanéac, O. Azzaroni, C. Sanchez, C. Boissiere, Following in situ the degradation of mesoporous silica in biorelevant conditions: at last, a good comprehension of the structure influence. ACS Appl. Mater. Interfaces 12(12), 13598 (2020)10.1021/acsami.9b19956 ↗
41. Q. Fu, M.N. Rahaman, H. Fu, X. Liu, Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. I. Preparation and in vitro degradation. J. Biomed. Mater. Res. Part A 95(1), 164 (2010)10.1002/jbm.a.32824 ↗
42. F. Chen, H. Hong, S. Shi, S. Goel, H.F. Valdovinos, R. Hernandez, C.P. Theuer, T.E. Barnhart, W. Cai, Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy. Sci. Rep. 4(1), 1 (2014)
43. A. Lukowiak, J. Lao, J. Lacroix, J.-M. Nedelec, Bioactive glass nanoparticles obtained through sol–gel chemistry. Chem. Commun. 49(59), 6620 (2013)10.1039/c3cc00003f ↗
44. N. Pajares-Chamorro, X. Chatzistavrou, Bioactive glass nanoparticles for tissue regeneration. ACS Omega 5(22), 12716 (2020)10.1021/acsomega.0c00180 ↗
45. I.A. Silver, J. Deas, M. Erecińska, Interactions of bioactive glasses with osteoblasts in vitro: effects of 45S5 Bioglass®, and 58S and 77S bioactive glasses on metabolism, intracellular ion concentrations and cell viability. Biomaterials 22(2), 175 (2001)10.1016/S0142-9612(00)00173-3 ↗
46. Y. Wang, H. Pan, X. Chen, The preparation of hollow mesoporous bioglass nanoparticles with excellent drug delivery capacity for bone tissue regeneration. Front. Chem. 7, 283 (2019)10.3389/fchem.2019.00283 ↗
47. A. Yao, D. Wang, W. Huang, Q. Fu, M.N. Rahaman, D.E. Day, In vitro bioactive characteristics of borate-based glasses with controllable degradation behavior. J. Am. Ceram. Soc. 90(1), 303 (2007)10.1111/j.1551-2916.2006.01358.x ↗
48. W. Huang, D.E. Day, K. Kittiratanapiboon, M.N. Rahaman, Kinetics and mechanisms of the conversion of silicate (45S5), borate, and borosilicate glasses to hydroxyapatite in dilute phosphate solutions. J. Mater. Sci. Mater. Med. 17(7), 583 (2006)10.1007/s10856-006-9220-z ↗
49. J. Sanz-Herrera, A. Boccaccini, Modelling bioactivity and degradation of bioactive glass based tissue engineering scaffolds. Int. J. Solids Struct. 48(2), 257 (2011)10.1016/j.ijsolstr.2010.09.025 ↗
50. M. Uo, M. Mizuno, Y. Kuboki, A. Makishima, F. Watari, Properties and cytotoxicity of water soluble Na2O–CaO–P2O5 glasses. Biomaterials 19(24), 2277 (1998)10.1016/S0142-9612(98)00136-7 ↗
51. F. Naghizadeh, N. Sultana, M.R.A. Kadir, T.M.T.M. Md. Shihabudin, R. Hussain, T. Kamarul, The fabrication and characterization of PCL/rice husk derived bioactive glass-ceramic composite scaffolds. J. Nanomater. 2014, 4–5 (2014)10.1155/2014/253185 ↗
52. M.-O. Montjovent, L. Mathieu, B. Hinz, L.L. Applegate, P.-E. Bourban, P.-Y. Zambelli, J.-A. Månson, D.P. Pioletti, Biocompatibility of bioresorbable poly (l-lactic acid) composite scaffolds obtained by supercritical gas foaming with human fetal bone cells. Tissue Eng. 11(11–12), 1640 (2005)10.1089/ten.2005.11.1640 ↗
53. E. Fujii, M. Ohkubo, K. Tsuru, S. Hayakawa, A. Osaka, K. Kawabata, C. Bonhomme, F. Babonneau, Selective protein adsorption property and characterization of nano-crystalline zinc-containing hydroxyapatite. Acta Biomater. 2(1), 69 (2006)10.1016/j.actbio.2005.09.002 ↗
54. D.D. Deligianni, N.D. Katsala, P.G. Koutsoukos, Y.F. Missirlis, Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials 22(1), 87 (2000)10.1016/S0142-9612(00)00174-5 ↗
55. A.H. Choi, B. Ben-Nissan, R.C. Conway, I.J. Macha, Advances in calcium phosphate nanocoatings and nanocomposites, in Advances in Calcium Phosphate Biomaterials, vol. 485 (Springer, Cham, 2014).10.1007/978-3-642-53980-0_16 ↗
56. M.A. Foreman, Y. Gu, J.D. Howl, S. Jones, S.J. Publicover, Group III metabotropic glutamate receptor activation inhibits Ca2+ influx and nitric oxide synthase activity in bone marrow stromal cells. J. Cell Physiol. 204(2), 704 (2005)10.1002/jcp.20353 ↗
57. R.J. Van’T Hof, S.H. Ralston, Nitric oxide and bone. Immunology 103(3), 255 (2001)10.1046/j.1365-2567.2001.01261.x ↗
58. M.H. Nascimento, M.T. Pelegrino, J.C. Pieretti, A.B. Seabra, How can nitric oxide help osteogenesis? AIMS Mol. Sci. 7(1), 29 (2020)10.3934/molsci.2020003 ↗
59. N.S. Hwang, S. Varghese, H.J. Lee, Z. Zhang, J. Elisseeff, Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells. Tissue Eng. Part A 19(15–16), 1723 (2013)10.1089/ten.tea.2013.0064 ↗
60. T.E. Danciu, R.M. Adam, K. Naruse, M.R. Freeman, P.V. Hauschka, Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett. 536(1–3), 193 (2003)10.1016/S0014-5793(03)00055-3 ↗
61. W. Liang, P. Ding, G. Li, E. Lu, Z. Zhao, Hydroxyapatite nanoparticles facilitate osteoblast differentiation and bone formation within sagittal suture during expansion in rats. Drug Des. Dev. Ther. 15, 905–906 (2021)10.2147/DDDT.S299641 ↗
62. P. Kalia, G. Vizcay-Barrena, J.P. Fan, A. Warley, L. Di Silvio, J. Huang, Nanohydroxyapatite shape and its potential role in bone formation: an analytical study. J. R. Soc. Interface 11(93), 20140004 (2014)10.1098/rsif.2014.0004 ↗
63. M. Vallet-Regi, Bio-ceramics with Clinical Applications (Wiley, Hoboken, 2014)10.1002/9781118406748 ↗
64. N.A.A. Halim, M.Z. Hussein, M.K. Kandar, Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery. Int. J. Nanomed. 16, 6477 (2021)10.2147/IJN.S298936 ↗
65. F. Balas, M. Manzano, P. Horcajada, M. Vallet-Regí, Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials. J. Am. Chem. Soc. 128(25), 8116 (2006)10.1021/ja062286z ↗
66. M. Colilla, I. Izquierdo-Barba, M. Vallet-Regí, Phosphorus-containing SBA-15 materials as bisphosphonate carriers for osteoporosis treatment. Microporous Mesoporous Mater. 135(1–3), 51 (2010)10.1016/j.micromeso.2010.06.010 ↗
67. M. Ashrafi, F. Ghalichi, B. Mirzakouchaki, M. Doblare, On the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model. Sci. Rep. 11(1), 1 (2021)10.1038/s41598-021-82502-y ↗
68. A. Stavropoulos, K. Bertl, P. Pietschmann, N. Pandis, M. Schiødt, B. Klinge, The effect of antiresorptive drugs on implant therapy: Systematic review and meta-analysis. Clin. Oral Implant Res. 29, 54 (2018)10.1111/clr.13282 ↗
69. A. Watermann, J. Brieger, Mesoporous silica nanoparticles as drug delivery vehicles in cancer. Nanomaterials 7(7), 189 (2017)10.3390/nano7070189 ↗
70. Y. Hu, K. Cai, Z. Luo, K.D. Jandt, Layer-by-layer assembly of β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis. Adv. Mater. 22(37), 4146 (2010)10.1002/adma.201000854 ↗
71. N. Al-Harbi, H. Mohammed, Y. Al-Hadeethi, A.S. Bakry, A. Umar, M.A. Hussein, M.A. Abbassy, K.G. Vaidya, G. Al Berakdar, E.M. Mkawi, Silica-based bioactive glasses and their applications in hard tissue regeneration: a review. Pharmaceuticals 14(2), 75 (2021)10.3390/ph14020075 ↗
72. I.D. Xynos, A.J. Edgar, L.D. Buttery, L.L. Hench, J.M. Polak, Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem. Biophys. Res. Commun. 276(2), 461 (2000)10.1006/bbrc.2000.3503 ↗
73. G. Kaur, O.P. Pandey, K. Singh, D. Homa, B. Scott, G. Pickrell, A review of bioactive glasses: their structure, properties, fabrication and apatite formation. J. Biomed. Mater. Res. Part A 102(1), 254 (2014)10.1002/jbm.a.34690 ↗
74. S.-B. Hua, J. Su, Z.-L. Deng, J.-M. Wu, L.-J. Cheng, X. Yuan, F. Chen, H. Zhu, D.-H. Qi, J. Xiao, Microstructures and properties of 45S5 bioglass® & BCP bioceramic scaffolds fabricated by digital light processing. Addit. Manuf. 45, 102074 (2021)
75. P. Ducheyne, Q. Qiu, Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials 20(23–24), 2287 (1999)10.1016/S0142-9612(99)00181-7 ↗
76. M. Bohner, J. Lemaitre, Can bioactivity be tested in vitro with SBF solution? Biomaterials 30(12), 2175 (2009)10.1016/j.biomaterials.2009.01.008 ↗
77. V. Marghussian, Biomedical applications of nano-glass ceramics, in Nano-Glass Ceramics: Processing, Properties and Applications, ed. by V. Marghussian, vol. 225 (Elsevier, Amsterdam, 2015)10.1016/B978-0-323-35386-1.00005-0 ↗
78. K. Bastari, M. Arshath, Z.H.M. Ng, J.H. Chia, Z.X.D. Yow, B. Sana, M.F.C. Tan, S. Lim, S.C.J. Loo, A controlled release of antibiotics from calcium phosphate-coated poly (lactic-co-glycolic acid) particles and their in vitro efficacy against Staphylococcus aureus biofilm. J. Mater. Sci. - Mater. Med. 25(3), 747 (2014)10.1007/s10856-013-5125-9 ↗
79. V. Sokolova, M. Epple, Biological and medical applications of calcium phosphate nanoparticles. Chemistry 27(27), 7471 (2021)10.1002/chem.202005257 ↗
80. A. Liu, G.-H. Xue, M. Sun, H.-F. Shao, C.-Y. Ma, Q. Gao, Z.-R. Gou, S.-G. Yan, Y.-M. Liu, Y. He, 3D printing surgical implants at the clinic: a experimental study on anterior cruciate ligament reconstruction. Sci. Rep. 6(1), 1 (2016)10.1038/s41598-016-0001-8 ↗
81. A. López-Noriega, E. Quinlan, N. Celikkin, F.J. O’Brien, Incorporation of polymeric microparticles into collagen-hydroxyapatite scaffolds for the delivery of a pro-osteogenic peptide for bone tissue engineering. APL Mater. 3(1), 014910 (2015)10.1063/1.4902833 ↗
82. S. Ishack, A. Mediero, T. Wilder, J.L. Ricci, B.N. Cronstein, Bone regeneration in critical bone defects using three-dimensionally printed β-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2. J. Biomed. Mater. Res. B Appl. Biomater. 105(2), 366 (2017)10.1002/jbm.b.33561 ↗
83. J.-G. Huang, L. Pang, Z.-R. Chen, X.-P. Tan, Dual-delivery of vancomycin and icariin from an injectable calcium phosphate cement-release system for controlling infection and improving bone healing. Mol. Med. Rep. 8(4), 1221 (2013)10.3892/mmr.2013.1624 ↗
84. S. Jiang, X. Liu, Y. Liu, J. Liu, W. He, Y. Dong, Synthesis of silver@ hydroxyapatite nanoparticles based biocomposite and their assessment for viability of osseointegration for rabbit knee joint anterior cruciate ligament rehabilitation. J. Photochem. Photobiol. B Biol. 202, 111677 (2020)10.1016/j.jphotobiol.2019.111677 ↗
85. Y. Lu, L. Li, M. Li, Z. Lin, L. Wang, Y. Zhang, Q. Yin, H. Xia, G. Han, Zero-dimensional carbon dots enhance bone regeneration, osteosarcoma ablation, and clinical bacterial eradication. Bioconjug. Chem. 29(9), 2982 (2018)10.1021/acs.bioconjchem.8b00400 ↗
86. Y. Jia, P. Zhang, Y. Sun, Q. Kang, J. Xu, C. Zhang, Y. Chai, Regeneration of large bone defects using mesoporous silica coated magnetic nanoparticles during distraction osteogenesis. Nanomed. Nanotechnol. Biol. Med. 21, 102040 (2019)10.1016/j.nano.2019.102040 ↗
87. T.-H. Kim, R.K. Singh, M.S. Kang, J.-H. Kim, H.-W. Kim, Inhibition of osteoclastogenesis through siRNA delivery with tunable mesoporous bioactive nanocarriers. Acta Biomater. 29, 352 (2016)10.1016/j.actbio.2015.09.035 ↗
88. Y. Tang, K. Luo, Y. Chen, Y. Chen, R. Zhou, C. Chen, J. Tan, M. Deng, Q. Dai, X. Yu, Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering. Bioact. Mater. 6(7), 2039 (2021)10.1016/j.bioactmat.2020.12.025 ↗
89. P. Mora-Raimundo, D. Lozano, M. Manzano, M. Vallet-Regí, Nanoparticles to knockdown osteoporosis-related gene and promote osteogenic marker expression for osteoporosis treatment. ACS Nano 13(5), 5451 (2019)10.1021/acsnano.9b00241 ↗
90. Z. Luo, S. Zhang, J. Pan, R. Shi, H. Liu, Y. Lyu, X. Han, Y. Li, Y. Yang, Z. Xu, Time-responsive osteogenic niche of stem cells: a sequentially triggered, dual-peptide loaded, alginate hybrid system for promoting cell activity and osteo-differentiation. Biomaterials 163, 25 (2018)10.1016/j.biomaterials.2018.02.025 ↗
91. M. Porgham Daryasari, M. Dusti Telgerd, M. Hossein Karami, A. Zandi-Karimi, H. Akbarijavar, M. Khoobi, E. Seyedjafari, G. Birhanu, P. Khosravian, F. SadatMahdavi, Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery. Artif. Cells Nanomed. Biotechnol. 47(1), 4020 (2019)10.1080/21691401.2019.1658594 ↗
92. B. Kuru, S. Yılmaz, K. Argın, Ü. Noyan, Enamel matrix derivative alone or in combination with a bioactive glass in wide intrabony defects. Clin. Oral Invest. 10(3), 227 (2006)10.1007/s00784-006-0052-5 ↗
93. B. Demir, D. Şengün, A. Berberoğlu, Clinical evaluation of platelet-rich plasma and bioactive glass in the treatment of intra-bony defects. J. Clin. Periodontol. 34(8), 709 (2007)10.1111/j.1600-051X.2007.01108.x ↗
94. E.S. Tadjoedin, G.L. De Lange, D. Lyaruu, L. Kuiper, E.H. Burger, High concentrations of bioactive glass material (BioGran®) vs. autogenous bone for sinus floor elevation: histomorphometrical observations on three split mouth clinical cases. Clin. Oral Implants Res. 13(4), 428–29 (2002)10.1034/j.1600-0501.2002.130412.x ↗
95. T. Van Vugt, J. Geurts, J. Arts, N. Lindfors: Biomaterials in treatment of orthopedic infections, in Management of Periprosthetic Joint Infections (PJIs), (Elsevier, Amsterdam, 2017), p. 4110.1016/B978-0-08-100205-6.00003-3 ↗
96. S. Sowmya, P.S. Kumar, K. Chennazhi, S. Nair, H. Tamura, R. Jayakumar, Biocompatible β-chitin hydrogel/nanobioactive glass ceramic nanocomposite scaffolds for periodontal bone regeneration. Artif. Organs 25(1), 1 (2011)
97. A.R. Boccaccini, M. Erol, W.J. Stark, D. Mohn, Z. Hong, J.F. Mano, Polymer/bioactive glass nanocomposites for biomedical applications: a review. Compos. Sci. Technol. 70(13), 1764 (2010)10.1016/j.compscitech.2010.06.002 ↗
98. T.A. Ostomel, Q. Shi, C.K. Tsung, H. Liang, G.D. Stucky, Spherical bioactive glass with enhanced rates of hydroxyapatite deposition and hemostatic activity. Small 2(11), 1261 (2006)10.1002/smll.200600177 ↗
99. C. Vichery, J.-M. Nedelec, Bioactive glass nanoparticles: from synthesis to materials design for biomedical applications. Materials 9(4), 288 (2016)10.3390/ma9040288 ↗
100. Z. Tang, X. Li, Y. Tan, H. Fan, X. Zhang, The material and biological characteristics of osteoinductive calcium phosphate ceramics. Regen. Biomater. 5(1), 43 (2018)10.1093/rb/rbx024 ↗