Drug delivery properties of three-dimensional ordered macroporous zinc-doped hydroxyapatite
Source abstract
Abstract
Porous hydroxyapatite (HA) as a drug carrier in drug delivery systems has been widely concerned. Three-dimensional ordered macroporous (3DOM) HA and 3DOM Zn-doped HA (Zn–HA) for drug delivery systems were successfully prepared to improve its amoxicillin loading and release rate. Effect of Zn doping amount on the 3DOM morphology and amoxicillin delivery properties of the HA were investigated. In the drug delivery test of amoxicillin, the prepared 3DOM Zn–HA (1 mol%) had a higher amoxicillin loading, and the drug loading of amoxicillin reached 101.4 mg g−1. The release rate of amoxicillin from the 3DOM Zn–HA (1 mol%) in the first 5 h was about 42.58%, which was significantly lower than that of pure 3DOM HA (55.37%). The 3DOM Zn–HA was expected to be a promising drug carrier for the biomedical field, though more detailed pre-clinical studies were necessary to verify these observations.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Layered Double Hydroxides Synthesis and Applications · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (19)
Show source-provided references
1. Q. Yuan, J. Wu, C. Qin, A. Xu, Z. Zhang, Y. Lin, Z. Chen, S. Lin, Z. Yuan, X. Ren, P. Zhang, One-pot synthesis and characterization of Zn-doped hydroxyapatite nanocomposites. Mater. Chem. Phys. 199, 122 (2017)10.1016/j.matchemphys.2017.06.047 ↗
2. Y. Ryabenkova, N. Jadav, M. Conte, M.F.A. Hippler, N. Reeves-Mclaren, P.D. Coates, P. Twigg, A. Paradkar, The mechanism of hydrogen-bonded complex formation between ibuprofen and nanocrystalline hydroxyapatite. Langmuir 33(12), 2965 (2017)10.1021/acs.langmuir.6b04510 ↗
3. M. Parent, H. Baradari, E. Champion, C. Damia, M. Viana-Trecant, Design of calcium phosphate ceramics for drug delivery applications in bone diseases: a review of the parameters affecting the loading and release of the therapeutic substance. J. Control. Release 252, 1 (2017)10.1016/j.jconrel.2017.02.012 ↗
4. A.T. Jani, N.B. Haghighi, M. Sheikh Hossein Pour, M. Aminian, S. Molzemi, Hydroxyapatite incorporation into MCM-41 and study of ibuprofen drug release. J. Aust. Ceram. Soc. 56(2), 653 (2020)10.1007/s41779-019-00384-w ↗
5. Z.L. Liu, Q.Y. Jia, X.D. Li, S.P. Li, J. Shen, J. Lin, D.X. Li, Synthesis of hollow mesoporous HAp-Au/MTX and its application in drug delivery. Colloids Surfaces A Physicochem. Eng. Asp. 586(2019), 124231 (2020)10.1016/j.colsurfa.2019.124231 ↗
6. Y. Han, Q. Wei, P. Chang, K. Hu, O. V. Okoro, A. Shavandi, and L. Nie: Three-dimensional printing of hydroxyapatite composites for biomedical application. Crystals11(4) (2021).10.3390/cryst11040353 ↗
7. S. Safi, F. Karimzadeh, S. Labbaf, Mesoporous and hollow hydroxyapatite nanostructured particles as a drug delivery vehicle for the local release of ibuprofen. Mater. Sci. Eng. C 92, 712 (2018)10.1016/j.msec.2018.07.004 ↗
8. S. Mondal, U. Pal, 3D hydroxyapatite scaffold for bone regeneration and local drug delivery applications. J. Drug Deliv. Sci. Technol. 53(April), 101131 (2019)10.1016/j.jddst.2019.101131 ↗
9. N. Eliaz, N. Metoki, Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications. Materials. 10(4), 334 (2017)10.3390/ma10040334 ↗
10. D. Xidaki, P. Agrafioti, D. Diomatari, A. Kaminari, E. Tsalavoutas-Psarras, P. Alexiou, V. Psycharis, E.C. Tsilibary, S. Silvestros, M. Sagnou, Synthesis of hydroxyapatite, β-Tricalcium phosphate and biphasic calcium phosphate particles to act as local delivery carriers of curcumin: loading, release and in vitro studies. Materials. 11(4), 595 (2018)10.3390/ma11040595 ↗
11. A.P.S. Prasanna, G.D. Venkatasubbu, Sustained release of amoxicillin from hydroxyapatite nanocomposite for bone infections. Prog. Biomater. 7(4), 289 (2018)10.1007/s40204-018-0103-4 ↗
12. Y. Xu, L. An, L. Chen, L. Cao, D. Zeng, G. Wang, A Facile chemical route to synthesize Zn doped hydroxyapatite nanorods for protein drug delivery. Mater. Chem. Phys. 214, 359 (2018)10.1016/j.matchemphys.2018.04.117 ↗
13. F. Ren, R. Xin, X. Ge, Y. Leng, Characterization and structural analysis of zinc-substituted hydroxyapatites. Acta Biomater. 5(8), 3141 (2009)10.1016/j.actbio.2009.04.014 ↗
14. H. Kim, S. Mondal, S. Bharathiraja, P. Manivasagan, M.S. Moorthy, J. Oh, Optimized Zn-doped hydroxyapatite/doxorubicin bioceramics system for efficient drug delivery and tissue engineering application. Ceram. Int. 44(6), 6062 (2018)10.1016/j.ceramint.2017.12.235 ↗
15. D. Predoi, S.L. Iconaru, A. Deniaud, M. Chevallet, I. Michaud-Soret, N. Buton, A.M. Prodan, Textural, structural and biological evaluation of hydroxyapatite doped with zinc at low concentrations. Materials 10(3), 229 (2017)10.3390/ma10030229 ↗
16. S. Shang, Q. Zhao, D. Zhang, R. Sun, Y. Tang, Molecular dynamics simulation of the adsorption behavior of two different drugs on hydroxyapatite and Zn-doped hydroxyapatite. Mater. Sci. Eng. C 105(September), 110017 (2019)10.1016/j.msec.2019.110017 ↗
17. E.A. Ofudje, A.I. Adeogun, M.A. Idowu, S.O. Kareem, Synthesis and characterization of Zn-Doped hydroxyapatite: scaffold application, antibacterial and bioactivity studies. Heliyon 5(5), e01716 (2019)10.1016/j.heliyon.2019.e01716 ↗
18. W. Yu, T.W. Sun, C. Qi, Z. Ding, H. Zhao, S. Zhao, Z. Shi, Y.J. Zhu, D. Chen, Y. He, Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation. Int. J. Nanomed. 12, 2293 (2017)10.2147/IJN.S126505 ↗
19. T. Limongi, F. Susa, M. Allione, E. Di Fabrizio, Drug delivery applications of three-dimensional printed (3DP) mesoporous scaffolds. Pharmaceutics 12(9), 1 (2020)10.3390/pharmaceutics12090851 ↗