Composite hydrogels comprised from interpenetrating networks of alginate-collagen-polyurethane for biomedicine
Source abstract
Abstract
AbstractNovel formulation of hydrogels based on interpenetrating networks of alginate-collagen-polyurethane (ACP) is presented. These materials have a porous semi-crystalline surface made by microspherical aggregates. Chemical crosslinking mediated by amide, urea, and urethane bonds allows to tailor the physicochemical properties of hydrogels, not affecting the native biocompatibility of alginate and collagen. The modification of the chemical structure of the polyurethane using hexamethylene diisocyanate or isophorone diisocyanate P(IPDI) can modulate the properties of these hydrogels. Hydrogels based on ACP(IPDI) present higher resistance to thermal degradation, slower degradation rate under both hydrolytic and proteolytic conditions and higher storage modulus, allowing the controlled release of cholecalciferol. Composite hydrogels present excellent hemocompatibility, antibacterial capacity, not presenting cytotoxic effects on fibroblasts and monocytes allowing their proliferation and decreasing the alpha tumoral necrosis factor secretion in monocytes. These biomaterials are candidates for healing of chronic wounds.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Wound Healing and Treatments · Hydrogels: synthesis, properties, applications · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (38)
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