Facile fabrication of catechin-loaded PLGA/chitosan nanofibers for effective nursing care of wound-infecting bacterial pathogens and healing
Source abstract
Abstract
A multifunctional catechin-encapsulated PLGA/chitosan nanofiber was fabricated using a simple electrospinning technique and an antimicrobial agent for wound healing applications. Incorporating catechin into the PLGA/chitosan matrix enhanced the thermal stability and pH-responsive drug release efficacy. CA@PLGA/CS nanofibers show almost 65% of catechin was released over 48 h. The antibacterial experiments confirmed that the CA@PLGA/CS nanofibers effectively reduced bacterial colonies. The MIC (IC50) values of pathogens were found to be 45.13 ± 1.02 μg/mL forS. aureusand 50.40 ± 1.03 μg/mL forE. coli. Antifungal assays indicated that the fabricated CA@PLGA/CS nanofibers inhibited againstA. fumigatusandC. albicans. The nanofibers demonstrated immediate cell regeneration and migration in fibroblast cells. Cytotoxicity studies confirmed that the CA@PLGA/CS nanofibers are biocompatible in non-cancerous cells. This investigation demonstrates that CA@PLGA/CS nanofibers matrix enhances the biomedical functionality of CA@PLGA/CS nanofibers, making them promising materials for infected wound healing and nursing care applications.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Silk-based biomaterials and applications · Advanced Sensor and Energy Harvesting Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (44)
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