Fabrication of chitosan-coated ciprofloxacin drug nanocomposite for combating antibacterial and respiratory infection leading to sepsis
Source abstract
Abstract
The lack of immunity and microbial infection that leads to sepsis is a potentially fatal condition of respiratory infection. Despite this, the development of current therapies and treatments for sepsis is hindered. Antibiotic-containing polymers linked together might enable sustainable drug release mechanisms. The CIF@CS nanocomposite (NCs) is stable in dispersion and generates ultra-fine particles that remain stable in aqueous conditions. The encapsulation of ciprofloxacin antibiotic in a chitosan biopolymer increased the crosslinking of targeted molecules. The antibacterial properties of Chitosan and ciprofloxacin will reveal a synergistic impact on ROS-mediated bacterial inhibition. Antibacterial activity studies demonstrated that the CIF@CS system eliminated human pathogenic microorganisms at minimal concentrations. Anti-fungal properties investigations reveal good growth suppression againstCandida albicans fungiandAspergillus fumigatus. Lastly, the L929 cytocompatibility study shows that the constructed CIF@CS NCs are safe for biological applications. The study results emphasize the development of intelligent drug delivery for sepsis control.Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Antimicrobial agents and applications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
Show source-provided references
1. A. Mu, W.P. Klare, S.L. Baines, C.N. Ignatius Pang, R. Guérillot, N. Harbison-Price, N. Keller, J. Wilksch, N.T.K. Nhu, M.-D. Phan, Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nat. Commun. 14, 1530 (2023)10.1038/s41467-023-37200-w ↗
2. Y. Kawai, A. Nakayama, H. Fukushima, Identification of sepsis-causing bacteria from whole blood without culture using primers with no cross-reactivity to human DNA. J. Microbiol. Methods 223, 106982 (2024)10.1016/j.mimet.2024.106982 ↗
3. B. Dyck, M. Unterberg, M. Adamzik, B. Koos, The impact of pathogens on sepsis prevalence and outcome. Pathogens 13, 89 (2024)10.3390/pathogens13010089 ↗
4. S.Y. Lee, M.H. Park, D.K. Oh, C.-M. Lim, Polymicrobial bloodstream infections per se do not increase mortality compared to monomicrobial bloodstream infections in sepsis patients: a Korean nationwide sepsis cohort study. BMC Infect. Dis. 24, 285 (2024)10.1186/s12879-024-09130-5 ↗
5. P. Priyanka, P.R. Meena, D. Raj, A. Rana, A. Dhanokar, K.S. Duggirala, A.P. Singh, Urinary tract infection and sepsis causing potential of multidrug-resistant extraintestinal pathogenic E. coli isolated from plant-origin foods. Int. J. Food Microbiol. 386, 110048 (2023)10.1016/j.ijfoodmicro.2022.110048 ↗
6. A. Özkavaklı, E.Y. İmamoğlu, N. Önder, S. İmamoğlu, H.F. Ovalı, Trends in causative organisms and antimicrobial resistance in late-onset neonatal sepsis. Turkish Arch. Pediatr. 59, 375 (2024)10.5152/TurkArchPediatr.2024.24006 ↗
7. H. Qadri, A.H. Shah, M. Alkhanani, A. Almilaibary, M.A. Mir, Immunotherapies against human bacterial and fungal infectious diseases: a review. Front. Med. 10, 1135541 (2023)10.3389/fmed.2023.1135541 ↗
8. M. Ayaz, C.-H. Li, Q. Ali, W. Zhao, Y.-K. Chi, M. Shafiq, F. Ali, X.-Y. Yu, Q. Yu, J.-T. Zhao, Bacterial and fungal biocontrol agents for plant disease protection: journey from lab to field, current status, challenges, and global perspectives. Molecules 28, 6735 (2023)10.3390/molecules28186735 ↗
9. M. Gholamzadeh, H. Abtahi, R. Safdari, Comparison of different machine learning algorithms to classify patients suspected of having sepsis infection in the intensive care unit. Inform. Med. Unlocked 38, 101236 (2023)10.1016/j.imu.2023.101236 ↗
10. F. Fauzi, M.M. Musawwa, H. Hidayat, A. Kusumaatmaja, W.S.B. Dwandaru, Nanocomposites based on biocompatible polymers and graphene oxide for antibacterial coatings. Polym. Polym. Compos. 29, S1609–S1620 (2021)
11. Y. Ahmadi, N. Moeini, M. Yadav, S. Ahmad, Antimicrobial polymer nanocomposite films and coatings, in Handbook of polymer nanocomposites for industrial applications. (Elsevier, Cham, 2021), pp.379–39710.1016/B978-0-12-821497-8.00012-5 ↗
12. M. Appu, H. Wu, H. Chen, J. Huang, Tea polyphenols mediated biogenic synthesis of chitosan-coated cerium oxide (CS/CeO2) nanocomposites and their potent antimicrobial capabilities. Environ. Sci. Pollut. Res. 30, 42575–42586 (2023)10.1007/s11356-022-19349-x ↗
13. R.S. Riseh, M. Vatankhah, M. Hassanisaadi, J.F. Kennedy, Chitosan-based nanocomposites as coatings and packaging materials for the postharvest improvement of agricultural product: a review. Carbohydr. Polym. 309, 120666 (2023)10.1016/j.carbpol.2023.120666 ↗
14. J. Yu, D. Wang, N. Geetha, K.M. Khawar, S. Jogaiah, M. Mujtaba, Current trends and challenges in the synthesis and applications of chitosan-based nanocomposites for plants: a review. Carbohydr. Polym. 261, 117904 (2021)10.1016/j.carbpol.2021.117904 ↗
15. F. Chogan, T. Mirmajidi, A.H. Rezayan, A.M. Sharifi, A. Ghahary, J. Nourmohammadi, A. Kamali, M. Rahaie, Design, fabrication, and optimization of a dual function three-layer scaffold for controlled release of metformin hydrochloride to alleviate fibrosis and accelerate wound healing. Acta Biomater. 113, 144–163 (2020). https://doi.org/10.1016/j.actbio.2020.06.03110.1016/j.actbio.2020.06.031 ↗
16. N. Gupta, D. Santhiya, A. Aditya, Tailored smart bioactive glass nanoassembly for dual antibiotic in vitro sustained release against osteomyelitis. J. Mater. Chem. B. 4, 7605–7619 (2016). https://doi.org/10.1039/C6TB01528J10.1039/C6TB01528J ↗
17. Y. Li, J. Rodrigues, H. Tomás, Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chem. Soc. Rev. 41, 2193–2221 (2012). https://doi.org/10.1039/C1CS15203C10.1039/C1CS15203C ↗
18. A.M. El-Khawaga, A.A. Farrag, M.A. Elsayed, G.S. El-Sayyad, A.I. El-Batal, Antimicrobial and photocatalytic degradation activities of chitosan-coated magnetite nanocomposite. J. Clust. Sci. 32, 1107–1119 (2021)10.1007/s10876-020-01869-6 ↗
19. T. Li, A. Hawley, T. Rades, B.J. Boyd, Exposure of liposomes containing nanocrystallised ciprofloxacin to digestive media induces solid-state transformation and altered in vitro drug release. J. Control. Release. 323, 350–360 (2020). https://doi.org/10.1016/j.jconrel.2020.04.03410.1016/j.jconrel.2020.04.034 ↗
20. N. Thattaruparambil Raveendran, A. Mohandas, R. Ramachandran Menon, A. Somasekharan Menon, R. Biswas, R. Jayakumar, Ciprofloxacin-and-incorporated chitosan bandages for the treatment of polymicrobial fluconazole-containing fibrin-nanoparticle wound infections. ACS Appl. Bio Mater. 2, 243–254 (2019). https://doi.org/10.1021/acsabm.8b0058510.1021/acsabm.8b00585 ↗
21. T.S. Anirudhan, V.C. Sekhar, Fabrication of functionalized layered double hydroxide/chitosan nanocomposite with dual responsive drug release for the targeted therapy of breast cancer. Eur. Polym. J. 139, 109993 (2020)10.1016/j.eurpolymj.2020.109993 ↗
22. S. Shinde, V. Folliero, A. Chianese, C. Zannella, A. De Filippis, L. Rosati, M. Prisco, A. Falanga, A. Mali, M. Galdiero, Synthesis of chitosan-coated silver nanoparticle bioconjugates and their antimicrobial activity against multidrug-resistant bacteria. Appl. Sci. 11, 9340 (2021)10.3390/app11199340 ↗
23. P.P. Sedghizadeh, S. Sun, A.F. Junka, E. Richard, K. Sadrerafi, S. Mahabady, N. Bakhshalian, N. Tjokro, M. Bartoszewicz, M. Oleksy, P. Szymczyk, M.W. Lundy, J.D. Neighbors, R.G.G. Russell, C.E. McKenna, F.H. Ebetino, Design, synthesis, and antimicrobial evaluation of a novel bone-targeting bisphosphonate-ciprofloxacin conjugate for the treatment of osteomyelitis biofilms. J. Med. Chem. 60, 2326–2343 (2017). https://doi.org/10.1021/acs.jmedchem.6b0161510.1021/acs.jmedchem.6b01615 ↗
24. E. Nyankson, S.O. Aboagye, J.K. Efavi, B. Agyei-Tuffour, L. Paemka, B.O. Asimeng, S. Balapangu, P.K. Arthur, E.K. Tiburu, Chitosan-coated halloysite nanotubes as vehicle for controlled drug delivery to MCF-7 cancer cells in vitro. Materials 14, 2837 (2021)10.3390/ma14112837 ↗
25. F. Rancan, M. Contardi, J. Jurisch, U. Blume-Peytavi, A. Vogt, I.S. Bayer, C. Schaudinn, Evaluation of drug delivery and efficacy of ciprofloxacin-loaded povidone foils and nanofiber mats in a wound-infection model based on ex vivo human skin. Pharmaceutics 11, 527 (2019)10.3390/pharmaceutics11100527 ↗
26. S.A. Mathew, P.A. Prakash, M.S.M. Jaabir, S. Dhanavel, R. Manikandan, A. Stephen, Dopamine-conjugated CuS/chitosan nanocomposite for targeted photothermal drug delivery: in vitro cytotoxicity study to establish bio-compatibility. J. Drug Deliv. Sci. Technol. 61, 102193 (2021)10.1016/j.jddst.2020.102193 ↗
27. S.S. Nanda, D.K. Yi, Recent advances in synergistic effect of nanoparticles and its biomedical application. Int. J. Mol. Sci. 25(6), 3266 (2024)10.3390/ijms25063266 ↗
28. D. Suhag, S. Kaushik, V.B. Taxak, Nanomaterials in biomedicine, in Handbook of biomaterials for medical applications, Volume 1: fundamentals. ed. by K. Jasmin (Springer Nature Singapore, Singapore, 2024), pp.91–12010.1007/978-981-97-4818-1_4 ↗
29. T.M. Nolte, B. Lu, Size and dose of nanoparticles modulate between toxic and medicinal effect on kidney. OpenNano (2024). https://doi.org/10.1016/j.onano.2024.10020010.1016/j.onano.2024.100200 ↗
30. B. Kumar, P. Kumar, Synthesis and characterization of pH-sensitive nanocarrier based chitosan-g-poly (itaconic acid) for ciprofloxacin delivery for anti-bacterial application. Int. J. Biol. Macromol. 268, 131604 (2024)10.1016/j.ijbiomac.2024.131604 ↗
31. S. Haseli, M. Pourmadadi, A. Samadi, F. Yazdian, M. Abdouss, H. Rashedi, M. Navaei-Nigjeh, A novel pH-responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan-based nanocarrier: emphasis on the concurrent improvement of loading, sustained release, and apoptosis induction. Biotechnol. Prog. 38, e3280 (2022)10.1002/btpr.3280 ↗
32. M. Bagheri, M. Validi, A. Gholipour, P. Makvandi, E. Sharifi, Chitosan nanofiber biocomposites for potential wound healing applications: antioxidant activity with synergic antibacterial effect. Bioeng. Transl. Med. 7, e10254 (2022). https://doi.org/10.1002/btm2.1025410.1002/btm2.10254 ↗
33. S.G. Padaga, H. Bhatt, S. Ch, S. Biswas, Glycol chitosan-poly (lactic acid) conjugate nanoparticles encapsulating ciprofloxacin: a mucoadhesive, antiquorum-sensing, and biofilm-disrupting treatment modality for bacterial keratitis. ACS Appl. Mater. Interfaces 16(15), 18360–18385 (2024)10.1021/acsami.3c18061 ↗
34. N.F.C.B. Melo, M.A.B. de Lima, T.L.M. Stamford, A. Galembeck, M.A.P. Flores, G.M. de Campos Takaki, J.A. da Costa Medeiros, T.M. Stamford-Arnaud, T.C. Montenegro Stamford, In vivo and in vitro antifungal effect of fungal chitosan nanocomposite edible coating against strawberry phytopathogenic fungi. Int. J. Food Sci. Technol. 55, 3381–3391 (2020)10.1111/ijfs.14669 ↗
35. K. Zomorodian, H. Veisi, S. Yazdanpanah, S. Najafi, A. Iraji, S. Hemmati, B. Karmakar, H. Veisi, Design and in vitro antifungal activity of nystatin loaded chitosan-coated magnetite nanoparticles for targeted therapy. Inorg. Nano-Metal Chem. 53, 852–860 (2023)10.1080/24701556.2021.1977821 ↗
36. V.S. Mirbagheri, A. Alishahi, G. Ahmadian, S.H. Petroudi, G. Romanazzi, Toward understanding the antibacterial mechanism of chitosan: experimental approach and in silico analysis. Food Hydrocoll. 147, 109382 (2024)10.1016/j.foodhyd.2023.109382 ↗
37. Y. Liu, Y. Xu, Q. Wen, Carbon dots for staining bacterial dead cells and distinguishing dead/alive bacteria. Anal. Biochem. 687, 115432 (2024)10.1016/j.ab.2023.115432 ↗
38. M. Jafarlou, Unveiling the menace: a thorough review of potential pandemic fungal disease. Front. Fungal Biol. 5, 1338726 (2024)10.3389/ffunb.2024.1338726 ↗
39. S. Mudenda, Global burden of fungal infections and antifungal resistance from 1961 to 2024: findings and future implications. Pharmacol. Pharm. 15(4), 81–112 (2024)10.4236/pp.2024.154007 ↗
40. T.D. Nguyen, Q.T. Pham, K.K. Nguyen, T.N. Nguyen, Stability study and antifungal activity of chitosan films from shrimp shells against colletotrichum gloeosporioides. Trop. J. Nat. Prod. Res. (2024). https://doi.org/10.26538/tjnpr/v8i6.210.26538/tjnpr/v8i6.2 ↗
41. S. Zare, M. Eskandani, S. Vandghanooni, H. Hossainpour, M. Jaymand, Ciprofloxacin-loaded chitosan-based nanocomposite hydrogel containing silica nanoparticles as a scaffold for bone tissue engineering application. Carbohydr. Polym. Technol. Appl. 7, 100493 (2024)
42. B. Gu, Q. Jiang, B. Luo, C. Liu, J. Ren, X. Wang, X. Wang, A sandwich-like chitosan-based antibacterial nanocomposite film with reduced graphene oxide immobilized silver nanoparticles. Carbohydr. Polym. 260, 117835 (2021)10.1016/j.carbpol.2021.117835 ↗
43. H.M. Fahmy, S. Shekewy, F.A. Elhusseiny, A. Elmekawy, Enhanced biocompatibility by evaluating the cytotoxic and genotoxic effects of magnetic iron oxide nanoparticles and chitosan on hepatocellular carcinoma cells (HCC). Cell Biochem. Biophys. 1, 1–16 (2024)
44. M.G. Antoniraj, H.L.J. Kumari, A. Shanmugarathinam, R. Kandasamy, pH-responsive chitosan copolymer synthesized via click chemistry for design of polymeric nanoparticles for targeted drug delivery. Carbohydr. Res. 542, 109200 (2024)10.1016/j.carres.2024.109200 ↗
45. R.M. Saleh, O.M. Hassan, Antibacterial, antibiofilm, and quorum quenching properties of biogenic chitosan silver nanoparticles against Staphylococcus aureus. BioNanoScience (2024). https://doi.org/10.1007/s12668-024-01573-z10.1007/s12668-024-01573-z ↗
46. R.M. Shawky, A.A. Hamed, Chitosan-silver nanoparticles conjugate mediated by endophytic fungus Talaromyces sp. 7S1: antimicrobial, antibiofilm and anticancer. Egypt. J. Chem. 67, 413–423 (2024)
47. I.R. Scolari, P.L. Páez, G.E. Granero, Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: a promising strategy for repositioning this first-line antibiotic. Heliyon 10, e25604 (2024)10.1016/j.heliyon.2024.e25604 ↗
48. S. Asadi, B. Mortezagholi, A. Hadizadeh, V. Borisov, M.J. Ansari, H. Shaker Majdi, A. Nishonova, H. Adelnia, B. Farasati Far, C. Chaiyasut, Ciprofloxacin-loaded titanium nanotubes coated with chitosan: a promising formulation with sustained release and enhanced antibacterial properties. Pharmaceutics 14, 1359 (2022)10.3390/pharmaceutics14071359 ↗
49. T.M. Almeleebia, M.H. Akhter, H. Khalilullah, M.A. Rahman, S. Ahmad, N. Alam, M.S. Ali, G. Khan, I.M.M. Alanazi, N. Shahzad, Co-delivery of naringin and ciprofloxacin by oleic acid lipid core encapsulated in carboxymethyl chitosan/alginate nanoparticle composite for enhanced antimicrobial activity. ACS Omega 9, 6845–6860 (2024)10.1021/acsomega.3c08200 ↗
50. R. Gil-Gonzalo, D.A. Durante-Salmerón, S. Pouri, E. Doncel-Pérez, A.R. Alcántara, I. Aranaz, N. Acosta, Chitosan-coated liposome formulations for encapsulation of ciprofloxacin and etoposide. Pharmaceutics 16, 1036 (2024)10.3390/pharmaceutics16081036 ↗
51. H. Ibne Shoukani, S. Nisa, Y. Bibi, A. Ishfaq, A. Ali, S. Alharthi, K. Tul Kubra, M. Zia, Green synthesis of polyethylene glycol coated, ciprofloxacin loaded CuO nanoparticles and its antibacterial activity against Staphylococcus aureus. Sci. Rep. 14, 21246 (2024)10.1038/s41598-024-72322-1 ↗
52. H. Ibne Shoukani, S. Nisa, Y. Bibi, M. Zia, A. Sajjad, A. Ishfaq, H. Ali, Ciprofloxacin loaded PEG coated ZnO nanoparticles with enhanced antibacterial and wound healing effects. Sci. Rep. 14, 4689 (2024)10.1038/s41598-024-55306-z ↗