journal article·2022-11-14

An ultrasensitive electrochemical DNA biosensor based on the highly conductive Nd–Sb-co-doped SnO2@Pt nanocomposite for the rapid detection of HIV-DNA

Enyang Ma, Chang Liu, Xiongfei Bai, Puyang Fan, Guang Li, Kexin Chen, Lei Li, Qing Qu

Journal of Materials Research· Volume 37· Issue 21
Publisher page

Abstract

Human immune deficiency virus (HIV) continues to cause havoc around the globe and has a significant impact on public safety. Therefore, a convenient method for the rapid detection of HIV-DNA is the key to the treatment and prevention of this kind of disease. In this work, we constructed an ultrasensitive electrochemical biosensor for the rapid detection of HIV-DNA based on Nd–Sb-co-doped SnO2@Pt electrode material. The doping of Sb and Nd increased oxygen vacancies of the SnO2crystal lattice, which greatly improved the conductivity of the material. Meanwhile, the spherical nanoflower structure of Nd–Sb-co-doped SnO2not only provided abundant attachment sites for Pt nanoparticles (Pt NPs) but also avoided the aggregation of DNA strands. Hence, the biosensor exhibited high sensitivity, good stability, outstanding selectivity, wide detection ranges (from 1.0 × 10−13to 1.0 × 10−7M), as well as a low limit of detection (0.099 pM) for HIV-DNA.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Biosensors and Analytical Detection · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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