Synthesis and evaluation of curcumin functionalized calcium polyphosphate for bone regeneration
Source abstract
Abstract
Inspired by the significances of calcium polyphosphate in bone cells metabolism regulation, curcumin functionalized calcium polyphosphate composites with different phosphate chain length were developed for various bone tissue engineering applications. The material characteristics were evaluated using various methods. Curcumin functionalized calcium polyphosphate composite with a chain length of 25 phosphate units (Cur–CaP25) exhibited irregular spherical amorphous particles of sub-micron size and the extracted curcumin has comparable anti-oxidant potential to free curcumin. It was found that the composite exhibited enhanced cell proliferation over curcumin and calcium polyphosphate alone. Besides, Cur–CaP25displayed higher curcumin loading content and superior regulation effect on osteoblast proliferation/differentiation/mineralization than the other three curcumin functionalized calcium phosphate composites. The curcumin loading efficiency and the ability to regulate osteoblast physiological activities of the composites were positively correlated with the phosphate chain length. Cur–CaP25proposed could be a promising material for various bone tissue engineering applications.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Coagulation, Bradykinin, Polyphosphates, and Angioedema · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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