Omeprazole and H2S releasing agents encapsulated in chitosan nanoparticles to enhance healing process against indomethacin-induced gastric ulcer model
Source abstract
Abstract
To develop nanoparticle carriers to improve gastric ulcer healing and provide protective effects against ulcers that affect over 10% of the population. Omeprazole entrapped and tetrathiomolybdate adsorbed chitosan nanoparticles were prepared and characterized, and the release of molybdenum was monitored. The gastroprotective effect and healing efficiency were evaluated for these nanoparticles on a rat model. Prepared chitosan nanoparticles carried 6.53 ± 0.22 mg of omeprazole and 11.15 ± 0.50 mg of tetrathiomolybdate. Molybdenum release was sustained over 72 h. An enhancement of fluorescence of Nile red added to CSNPS@OME@ATM at pH 2.5 and 6.5 indicates the release of H2S, an essential trigger for ulcer healing. Nitrite levels (1.37 mmol/g), catalase activity (33.68 mmol H2O2/min/mg protein), decreased gastric juice content, and histopathological evaluation confirmed the protective and ulcer-healing nature. The study confirmed that chitosan nanoparticles with omeprazole and tetrathiomolybdate have superior protection and healing of gastric ulcer.Graphical abstractGastric ulcer healing through drug encapsulated chitosan nanoparticles
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Sulfur Compounds in Biology · Ginger and Zingiberaceae research · Hydrogen's biological and therapeutic effects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
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