Bioactive bacterial cellulose–chitosan composite scaffolds for prospective periodontal tissue regeneration
Source abstract
Abstract
Periodontal defects due to infections must be treated to reconstruct the shape and characteristics of periodontal tissues including cementum and periodontal ligament. Freeze-dried composite scaffolds were synthesized from bacterial cellulose, chitosan, hydroxyapatite (HA), and pomegranate peel extract (PG extract). The PG is an active wound-healing phytochemical from peels of pomegranate fruit, extracted and characterized through UV, FTIR, and GCMS analysis. These GTR scaffolds were synthesized by freeze gelation using 0.4%, 0.8%, and 1.2%-PG and were freeze dried. Interestingly, the surface morphology revealed 3 distinct microstructures for each composite having porous, and foam-like appearance with interconnected channels. FTIR results suggest the presence of each compound including PG. The XRD results show main peaks of CH, BC, and HA. The extract release from hydrophilic composites was in dose- and time-dependent manner with a microbicidal effect and high biocompatibility and wound-healing ability. Thus, formed scaffolds can be periodontal regenerative materials.Graphical abstractMethod of fabrication and characterization of Composite osteogenic CH–BC–HA–PG scaffolds for periodontal tissue regeneration.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Periodontal Regeneration and Treatments · Oral microbiology and periodontitis research · Oral and gingival health research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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