Fabrication and in vitro characterization of novel co-electrospun polycaprolactone/collagen/polyvinylpyrrolidone nanofibrous scaffolds for bone tissue engineering applications
Source abstract
Abstract
Electrospinning is a facile method to create a porous fibrous structure. Therefore, here, co-electrospun polycaprolactone (PCL)/collagen (COL)/polyvinylpyrrolidone (PVP) (PCL/COL/PVP) nanofibrous scaffolds were synthesized for bone regeneration. Morphology observations demonstrated bead-free uniform fibrous structure. Fiber diameter measurements showed relatively uniform fiber distribution with the most fiber diameter in the range of 0.1–1 μm for PCL/COL/PVP scaffold. X-ray diffraction test revealed semi-crystalline nature of the scaffold due to the existence of PCL. Furthermore, mechanical, wettability, swelling, and biodegradability properties of scaffolds were evaluated and it was concluded that addition of COL and PVP to the PCL scaffold improved the mentioned properties. The PCL/COL/PVP nanofibrous scaffolds had acceptable interactions with MG-63 cells and showed high cell metabolism. According to Alizarin red staining, the scaffold showed great Ca deposition and mineralization. It seems that co-electrospinning of the PCL/COL/PVP nanofibrous scaffold can meet the basic required specifications for bone tissue engineering.Graphical abstractSchematic of co-electrospinning of the PCL/COL/PVP scaffolds.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Tissue Engineering and Regenerative Medicine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (59)
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