Photocatalytic antibacterial properties and mechanism of PEG-modified superparamagnetic iron oxide nanoparticles
Source abstract
Abstract
Today, bacterial infections have jumped to an extremely critical health crisis and have become one of the most pressing health threats. 10 million people will die per year because of bacterial infections by 2050. There is an urgent need to develop a new antibacterial strategy to deal with bacterial infections. In this study, PEG-modified superparamagnetic iron oxide nanoparticles (PEG-SPIONs) were prepared using an ultra-straightforward high thermal decomposition method. The synthesized PEG-SPIONs showed excellent biocompatibility, stability, superparamagnetic, and photocatalytic properties. It is worth noting that PEG-SPIONs have excellent photocatalytic antimicrobial activity againstE. coliandS. aureus. In addition, the antimicrobial mechanism revealed that PEG-SPIONs could inhibit the formation of bacterial biofilms and cause disruption of bacterial biofilms, the crumple or rupture of bacteria, triggering inclusion leakage and Reactive Oxygen Species production, while avoiding inducing drug resistance. In conclusion, PEG-SPIONs have great potential for application as an efficient photocatalytic antibacterial material.Graphical abstractThe synthesis (a) and antibacterial schematic diagram (b) of PEG-SPIONs. We prepared PEG-modified superparamagnetic iron oxide nanoparticles (PEG-SPIONs) using an ultra-simple pyrolysis method. The synthesized PEG-SPIONs showed good biocompatibility, stability, superparamagnetic, and photocatalytic properties. It is worth noting that PEG-SPIONs have excellent photocatalytic antimicrobial activity against E. coli and S. aureus. In addition, the antimicrobial mechanism revealed that PEG-SPIONs could inhibit the formation of bacterial biofilms and cause disruption of bacterial biofilms, the crumple or rupture of bacteria, leading to leakage of inclusions and the generation of reactive oxygen species (ROS) without inducing the drug resistance of bacteria. In conclusion, the prepared PEG-SPIONs are promising for photocatalytic synergistic antimicrobial applications. This work serves as a reference for developing various functional photocatalytic nanomaterials for exploitation strategies and applications.Photocatalytic antibacterial properties and mechanism of PEG-modified superparamagnetic iron oxide nanoparticles
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (58)
Show source-provided references
1. S.A.A. Rizvi, G.P. Einstein, O.L. Tulp, F. Sainvil, R. Branly, Introduction to traditional medicine and their role in prevention and treatment of emerging and Re-emerging diseases. Biomolecules (2022). https://doi.org/10.3390/biom1210144210.3390/biom12101442 ↗
2. S. Duan, R. Wu, Y.H. Xiong, H.M. Ren, C. Lei, Y.Q. Zhao, X.Y. Zhang, F.J. Xu, Multifunctional antimicrobial materials: From rational design to biomedical applications. Prog. Mater. Sci. (2021). https://doi.org/10.1016/j.pmatsci.2021.10088710.1016/j.pmatsci.2021.100887 ↗
3. S. Khanna, R. Pardi, Clostridioides difficile infection: curbing a difficult menace. Ther. Adv. Gastroenterol. (2022). https://doi.org/10.1177/1756284822108990610.1177/17562848221089906 ↗
4. C. Wang, Y. Yang, Y. Cao, K. Liu, H. Shi, X. Guo, W. Liu, R. Hao, H. Song, R. Zhao, Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection. Biomater. Sci. (2022). https://doi.org/10.1039/d2bm01489k10.1039/d2bm01489k ↗
5. M. Evgenia, E. Lara, S. Folke, R.R. McCarthy, Burns and biofilms: priority pathogens and in vivo models. npj Biofilms and Microbiomes (2021). https://doi.org/10.1038/s41522-021-00243-210.1038/s41522-021-00243-2 ↗
6. C. Wang, C. Li, X. Li, L. Cai, Z. Han, R. Du, Burn wounds: proliferating site for biofilm infection. Appl. Biochem. Biotechnol. (2022). https://doi.org/10.1007/s12010-022-03964-y10.1007/s12010-022-03964-y ↗
7. R. Yahya, N.M. Alharbi, Biosynthesized silver nanoparticles-capped chondroitin sulfate nanogel targeting microbial infections and biofilms for biomedical applications. Int. J. Biol. Macromol. (2023). https://doi.org/10.1016/j.ijbiomac.2023.12708010.1016/j.ijbiomac.2023.127080 ↗
8. M. Di Pietro, S. Filardo, R. Sessa, Editorial for the special issue antibacterial activity of drug-resistant strains. Int. J. Mol. Sci. 25, 1878 (2024)10.3390/ijms25031878 ↗
9. M.D. Torres, J. Cao, O.L. Franco, T.K. Lu, C. de la Fuente-Nunez, Synthetic biology and computer-based frameworks for antimicrobial peptide discovery. ACS Nano (2021). https://doi.org/10.1021/acsnano.0c0950910.1021/acsnano.0c09509 ↗
10. M.A. Mahmoud, M. Abdelsalam, O.A. Mahdy, H.M. El Miniawy, Z.A. Ahmed, A.H. Osman, H.M. Mohamed, A.M. Khattab, M.Z. Ewiss, Infectious bacterial pathogens, parasites and pathological correlations of sewage pollution as an important threat to farmed fishes in Egypt. Environ. Pollut. (2016). https://doi.org/10.1016/j.envpol.2016.09.04410.1016/j.envpol.2016.09.044 ↗
11. C. Nurizzo, Reclaimed water reuse in the Mediterranean region: some considerations on water resources, standards and bacterial re-growth phenomena. Water Sci. Technol. Water Supply (2018). https://doi.org/10.2166/ws.2003.007810.2166/ws.2003.0078 ↗
12. S. Dula, T.A. Ajayeoba, O.A. Ijabadeniyi, Bacterial biofilm formation on stainless steel in the food processing environment and its health implications. Folia Microbiol. (2021). https://doi.org/10.1007/s12223-021-00864-210.1007/s12223-021-00864-2 ↗
13. F. Rossi, S. Santonicola, C. Amadoro, L. Marino, G. Colavita, Recent records on bacterial opportunistic infections via the dietary route. Microorganisms (2023). https://doi.org/10.3390/microorganisms1201006910.3390/microorganisms12010069 ↗
14. M. Bonten, Tales of the unexpected in antibiotic resistance. J. Hosp. Infect. (2022). https://doi.org/10.1016/j.jhin.2022.02.01910.1016/j.jhin.2022.02.019 ↗
15. S. Haberl Meglič, D. Slokar, D. Miklavčič, Inactivation of antibiotic-resistant bacteria Escherichia coli by electroporation. Front. Microbiol. (2024). https://doi.org/10.3389/fmicb.2024.134700010.3389/fmicb.2024.1347000 ↗
16. J. Li, S. Feng, X. Liu, X. Jia, F. Qiao, J. Guo, S. Deng, Effects of traditional Chinese medicine and its active ingredients on drug-resistant bacteria. Front. Pharmacol. (2022). https://doi.org/10.3389/fphar.2022.83790710.3389/fphar.2022.837907 ↗
17. C.G. Bunick, J. Keri, S.K. Tanaka, N. Furey, G. Damiani, J.L. Johnson, A. Grada, Antibacterial mechanisms and efficacy of sarecycline in animal models of infection and inflammation. Antibiotics (2021). https://doi.org/10.3390/antibiotics1004043910.3390/antibiotics10040439 ↗
18. J.A. Santos, M.H. Lamers, Novel antibiotics targeting bacterial replicative DNA polymerases. Antibiotics (2020). https://doi.org/10.3390/antibiotics911077610.3390/antibiotics9110776 ↗
19. H. Chandra, P. Bishnoi, A. Yadav, B. Patni, A.P. Mishra, A.R. Nautiyal, Antimicrobial resistance and the alternative resources with special emphasis on plant-based antimicrobials—a review. Plants (2017). https://doi.org/10.3390/plants602001610.3390/plants6020016 ↗
20. J. Wang, X. Zhu, W. Pei, L. Zhou, L. Cai, H. Jiang, J. Chen, ZnO nanocluster loaded superparamagnetic iron oxide nanocomposites as recyclable antibacterial agent. Colloid Interface Sci. Commun. (2021). https://doi.org/10.1016/j.colcom.2021.10051010.1016/j.colcom.2021.100510 ↗
21. G. Martelli, D. Giacomini, Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. Eur. J. Med. Chem. (2018). https://doi.org/10.1016/j.ejmech.2018.09.00910.1016/j.ejmech.2018.09.009 ↗
22. H.A. Rasheed, A. Rehman, A. Karim, F. Al-Asmari, H. Cui, L. Lin, A comprehensive insight into plant-derived extracts/bioactives: exploring their antimicrobial mechanisms and potential for high-performance food applications. Food Biosci. (2024). https://doi.org/10.1016/j.fbio.2024.10403510.1016/j.fbio.2024.104035 ↗
23. D. Kang, D. Bagchi, I.A. Chen, Pharmacokinetics and biodistribution of phages and their current applications in antimicrobial therapy. Adv. Ther. (2023). https://doi.org/10.1002/adtp.20230035510.1002/adtp.202300355 ↗
24. L. Ushanov, B. Lasareishvili, I. Janashia, A.E. Zautner, application of campylobacter jejuni phages: challenges and perspectives. Animals (2020). https://doi.org/10.3390/ani1002027910.3390/ani10020279 ↗
25. X. Ma, W. Tang, R. Yang, Bioinspired nanomaterials for the treatment of bacterial infections. Nano Res. (2023). https://doi.org/10.1007/s12274-023-6283-910.1007/s12274-023-6283-9 ↗
26. E.O. Ogunsona, R. Muthuraj, E. Ojogbo, O. Valerio, T.H. Mekonnen, Engineered nanomaterials for antimicrobial applications: a review. Appl. Mater. Today (2019). https://doi.org/10.1016/j.apmt.2019.10047310.1016/j.apmt.2019.100473 ↗
27. A. Frei, A.D. Verderosa, A.G. Elliott, J. Zuegg, M.A.T. Blaskovich, Metals to combat antimicrobial resistance. Nat. Rev. Chem. (2023). https://doi.org/10.1038/s41570-023-00463-410.1038/s41570-023-00463-4 ↗
28. M. Nakhaei, K. Akhbari, A. Phuruangrat, Synthesis and characterization of silver and copper metal–organic hybrid nanomaterials and their biological application. Colloid and Polym. Sci. (2021). https://doi.org/10.1007/s00396-020-04788-010.1007/s00396-020-04788-0 ↗
29. C.A. Shahed, F. Ahmad, E. Günister, F.M. Foudzi, S. Ali, K. Malik, W.S.W. Harun, Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys: a review. J. Magnes. Alloys (2023). https://doi.org/10.1016/j.jma.2023.08.01810.1016/j.jma.2023.08.018 ↗
30. M. Zhang, S. Han, X. Niu, H. Li, D. Zhang, H. Fan, X. Liu, K. Wang, PPy and CQDs-doped novel CuO nanocomposites for enhanced antibacterial activity against drug-resistant bacteria. ChemistrySelect (2022). https://doi.org/10.1002/slct.20220363610.1002/slct.202203636 ↗
31. Z. Liu, X. Qu, New insights into nanomaterials combating bacteria: ROS and beyond. Sci. China Life Sci. (2018). https://doi.org/10.1007/s11427-018-9417-110.1007/s11427-018-9417-1 ↗
32. R. Lubart, Metal-oxide nanoparticles increase the bactericidal effect of blue light. Photomed. Laser Surg. (2012). https://doi.org/10.1089/pho.2012.989110.1089/pho.2012.9891 ↗
33. T. Kumeria, Advances on porous nanomaterials for biomedical application (Drug delivery, sensing, and tissue engineering). ACS Biomater. Sci. Eng. (2022). https://doi.org/10.1021/acsbiomaterials.2c0110310.1021/acsbiomaterials.2c01103 ↗
34. H. Zhang, J. Cui, J. Yang, H. Yan, X. Zhu, Y. Shao, H. Zhang, J. Zhu, Effect of carrier materials for active silver in antibacterial powder coatings. Coatings (2024). https://doi.org/10.3390/coatings1403029710.3390/coatings14030297 ↗
35. D. Yancey-Gray, R. Nyamwihura, Z. Arslan, I.V. Ogungbe, Antibacterial activities of copper, silver, and zinc-derived nanoparticles and their capacity to enhance the antimicrobial activities of antibiotics. Curr. Nanosci. (2024). https://doi.org/10.2174/01157341373010102405071015310.2174/011573413730101024050710153 ↗
36. N. Liu, G. Chen, W. Dong, C. Liu, C. Xu, Preparation of Au nanoparticles with high dispersion and thermal stability by a controlled impregnation method for alcohol oxidation. Gold Bull. (2017). https://doi.org/10.1007/s13404-017-0206-z10.1007/s13404-017-0206-z ↗
37. B. Asgari Lajayer, N. Najafi, E. Moghiseh, M. Mosaferi, J. Hadian, Removal of heavy metals (Cu2+ and Cd2+ ) from effluent using gamma irradiation, titanium dioxide nanoparticles and methanol. J. Nanostruct. Chem. (2018). https://doi.org/10.1007/s40097-018-0292-310.1007/s40097-018-0292-3 ↗
38. P. Panjan, A. Drnovšek, M. Čekada, M. Panjan, Contamination of substrate-coating interface caused by ion etching. Coatings (2022). https://doi.org/10.3390/coatings1206084610.3390/coatings12060846 ↗
39. F. Wahid, C. Zhong, H.-S. Wang, X.-H. Hu, L.-Q. Chu, Recent advances in antimicrobial hydrogels containing metal ions and metals/metal oxide nanoparticles. Polymers (2017). https://doi.org/10.3390/polym912063610.3390/polym9120636 ↗
40. M. Nouri Hajbaba, M. Pourmadadi, F. Yazdian, H. Rashedi, M. Abdouss, D.S. Zhohrabi, The function of chitosan/agarose biopolymer on Fe2O3 nanoparticles and evaluation of their effects on MCF-7 breast cancer cell line and expression of BCL2 and BAX genes. Biotechnol Prog (2022). https://doi.org/10.1002/btpr.330510.1002/btpr.3305 ↗
41. N. Tabassum, V. Singh, V.K. Chaturvedi, E. Vamanu, M.P. Singh, A facile synthesis of flower-like iron oxide nanoparticles and its efficacy measurements for antibacterial cytotoxicity and antioxidant activity. Pharmaceutics (2023). https://doi.org/10.3390/pharmaceutics1506172610.3390/pharmaceutics15061726 ↗
42. M. Balk, T. Haus, J. Band, H. Unterweger, E. Schreiber, R.P. Friedrich, C. Alexiou, A.-O. Gostian, Cellular SPION uptake and toxicity in various head and neck cancer cell lines. Nanomaterials (2021). https://doi.org/10.3390/nano1103072610.3390/nano11030726 ↗
43. J. Dulińska-Litewka, A. Łazarczyk, P. Hałubiec, O. Szafrański, K. Karnas, A. Karewicz, Superparamagnetic iron oxide nanoparticles—Current and prospective medical applications. Materials (2019). https://doi.org/10.3390/ma1204061710.3390/ma12040617 ↗
44. H. Wei, Y. Hu, J. Wang, X. Gao, X. Qian, M. Tang, Superparamagnetic iron oxide nanoparticles: cytotoxicity, metabolism, and cellular behavior in biomedicine applications. Int. J. Nanomed. (2021). https://doi.org/10.2147/ijn.s32198410.2147/ijn.s321984 ↗
45. J. Wang, B. Zhang, L. Wang, M. Wang, F. Gao, One-pot synthesis of water-soluble superparamagnetic iron oxide nanoparticles and their MRI contrast effects in the mouse brains. Biomater. Adv. (2014). https://doi.org/10.1016/j.msec.2014.12.02610.1016/j.msec.2014.12.026 ↗
46. J. Wang, B. Zhang, G. Yang, L. Su, L. Wang, F. Gao, Transferrin-conjugated superparamagnetic iron oxide nanoparticles as in vivo magnetic resonance imaging contrast agents. J. Nanosci. Nanotechnol. (2020). https://doi.org/10.1166/jnn.2020.1731110.1166/jnn.2020.17311 ↗
47. X. Zhu, J. Wang, L. Cai, Y. Wu, M. Ji, H. Jiang, J. Chen, Dissection of the antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies. J. Hazard. Mater. (2022). https://doi.org/10.1016/j.jhazmat.2022.12843610.1016/j.jhazmat.2022.128436 ↗
48. H. Bantawal, U.S. Shenoy, D.K. Bhat, Vanadium-doped SrTiO3 nanocubes: insight into role of vanadium in improving the photocatalytic activity. Appl. Surf. Sci. (2020). https://doi.org/10.1016/j.apsusc.2020.14585810.1016/j.apsusc.2020.145858 ↗
49. L. Zhang, H. Qi, Y. Zhao, L. Zhong, Y. Zhang, Y. Wang, J. Xue, Y. Li, Au nanoparticle modified three-dimensional network PVA/RGO/TiO2 composite for enhancing visible light photocatalytic performance. Appl. Surf. Sci. (2019). https://doi.org/10.1016/j.apsusc.2019.14385510.1016/j.apsusc.2019.143855 ↗
50. J. Jiang, Y. Jia, Y. Wang, R. Chong, L. Xu, X. Liu, Insight into efficient photocatalytic elimination of tetracycline over SrTiO3(La, Cr) under visible-light irradiation: the relationship of doping and performance. Appl. Surf. Sci. (2019). https://doi.org/10.1016/j.apsusc.2019.04.26110.1016/j.apsusc.2019.04.261 ↗
51. J. Wang, J. Xuan, Y. Liu, Z. Li, Y. Han, Z. Wang, NIR-dependent photothermal-photodynamic synergistic antibacterial mechanism for titanium carbide nanosheets intercalated and delaminated by tetramethylammonium hydroxide. Biomater. Adv. (2023). https://doi.org/10.1016/j.bioadv.2023.21349210.1016/j.bioadv.2023.213492 ↗
52. X.-M. Jia, C. Cheng, T. Liu, Y.-L. Zhao, B. Guo, L. Tang, Y.-Y. Yang, Synthesis and antibiofilm evaluation of N-acyl-2-aminopyrimidine derivatives against acinetobacter baumannii. Bioorg. Med. Chem (2022). https://doi.org/10.1016/j.bmc.2022.11709510.1016/j.bmc.2022.117095 ↗
53. J. Palacci, S. Sacanna, S.H. Kim, G.R. Yi, D.J. Pine, P.M. Chaikin, Light-activated self-propelled colloids. Philos. Trans. of the R. Soc. A: Math. Phys. Eng. Sci. (2014). https://doi.org/10.1098/rsta.2013.0372.(1)10.1098/rsta.2013.0372.(1) ↗
54. M. Youssef, A. Morin, A. Aubret, S. Sacanna, J. Palacci, Rapid characterization of neutral polymer brush with a conventional zetameter and a variable pinch of salt. Soft Matter 16(17), 4274–4282 (2020). https://doi.org/10.1039/c9sm01850f.(1)10.1039/c9sm01850f.(1) ↗
55. K. Kharga, I. Dhar, S. Kashyap, S. Sengupta, D. Kumar, L. Kumar, Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm. World J. Microbiol. Biotechnol. (2024). https://doi.org/10.1007/s11274-023-03716-y10.1007/s11274-023-03716-y ↗
56. R. Ullah, Semiconductor ZnFe2O4 as efficient photocatalyst for the degradation of organic dyes: an update. J. Chem. Rev. (2023). https://doi.org/10.48309/JCR.2023.407658.123210.48309/JCR.2023.407658.1232 ↗
57. O.K. Akeremale, Metal-organic frameworks (MOFs) as adsorbents for purification of dye-contaminated wastewater: a review. J. Chem. Rev (2022). https://doi.org/10.22034/JCR.2022.314728.113010.22034/JCR.2022.314728.1130 ↗
58. N.E. Al-Hazmi, D.M. Naguib, Antioxidant and antibacterial activities of nano-probiotics versus free probiotics against gastrointestinal pathogenic bacteria. Indian J Microbiol (2024). https://doi.org/10.1007/s12088-023-01140-210.1007/s12088-023-01140-2 ↗