Experimental study of in-vitro bioanalysis and in-vivo living tissue biocompatibility of Mg–Zn alloys
Source abstract
Abstract
In this study in-vitro bioanalysis and in-vivo living tissue biocompatibility were evaluated. Pure Mg and Mg + x Zn (x = 1 and 3 wt%) alloys have been used in the study. In vitro immersion and potentiodynamic corrosion were applied to these alloys in Hank’s and artificial seawater solution. The materials were kept in living tissue (gluteus-superficial) for 7 weeks in-vivo (albino-rat). After 4 and 7 week, the control and experimental groups’ urine parameters, blood mineral substance levels, and radiographic image controls were evaluated. It was observed that the bio-dissolution level decreased as the Zn-ratio increased. As a result, successful results were obtained in the biocompatible and biodegradable material class of Zn-doped Mg alloys used in the study. The dissolution amount of 1.03 mm/y (for Mg + 3Zn alloy) in Hank’s solution was calculated. The % vitality was determined at the level of 117%. Graphical abstract: [Figure not available: see fulltext.]
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Bone Tissue Engineering Materials · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (65)
Show source-provided references
1. A. Fekry, R.M. El-Sherif, Electrochim. Acta (2009). https://doi.org/10.1016/j.electacta.2009.07.04710.1016/j.electacta.2009.07.047 ↗
2. J. Gray, B. Luan, J. Alloys Compds. (2002). https://doi.org/10.1016/S0925-8388(01)01899-010.1016/S0925-8388(01)01899-0 ↗
3. P. Makkar et al., J. Appl. Biomater. Funct. Mater. (2018). https://doi.org/10.1177/228080001775035910.1177/2280800017750359 ↗
4. Y. Zhang et al., Surf. Coat. Technol. (2002). https://doi.org/10.1016/S0257-8972(02)00342-010.1016/S0257-8972(02)00342-0 ↗
5. N. Sezer et al., J. Magn. Alloy (2018). https://doi.org/10.1016/j.jma.2018.02.00310.1016/j.jma.2018.02.003 ↗
6. Y.F. Zheng, X.N. Gu, F. Witte, Mater. Sci. Eng. R Rep. (2014). https://doi.org/10.1016/j.mser.2014.01.00110.1016/j.mser.2014.01.001 ↗
7. M. Nabiyouni et al., Acta Biomater. (2018). https://doi.org/10.1016/j.actbio.2017.11.03310.1016/j.actbio.2017.11.033 ↗
8. M.S. Uddin, C. Hall, P. Murphy, Sci. Technol. Adv. Mater. (2015). https://doi.org/10.1088/1468-6996/16/5/05350110.1088/1468-6996/16/5/053501 ↗
9. K. Kainer, F. Von Buch, J. Magn. Alloys (2003). https://doi.org/10.1002/3527602046.ch110.1002/3527602046.ch1 ↗
10. M.M. Avedesian, H. Baker, Corrosion 274, 350 (1999)
11. Motegi, T., Y. Tamura, Y. Sanpei, in Magnesium Alloys, ed. by M. Co, Editor. Canadian Patent Application (2008)
12. X.-N. Gu, Y.-F. Zheng, Front. Mater. Sci. (2010). https://doi.org/10.1007/s11706-010-0024-110.1007/s11706-010-0024-1 ↗
13. S. González et al., in Biodegradation-Engineering and Technology. ed. by R. Chamy (IntechOpen, Croatia, 2013), p.476
14. L. Gu et al., Biomed. Mater. (2019). https://doi.org/10.1088/1748-605X/ab158310.1088/1748-605X/ab1583 ↗
15. Y.-K. Kim et al., Sci. Technol. Adv. Mater. (2018). https://doi.org/10.1080/14686996.2018.145171710.1080/14686996.2018.1451717 ↗
16. Q. Chen, G.A. Thouas, Mater. Sci. Eng. R Rep. (2015). https://doi.org/10.1016/j.mser.2014.10.00110.1016/j.mser.2014.10.001 ↗
17. N. Kurgan et al., Sci. Bull. (2012). https://doi.org/10.1007/s11434-012-5022-510.1007/s11434-012-5022-5 ↗
18. J. Buckwalter et al., J. Bone Jt. Surg. Am. (1995). https://doi.org/10.2106/00004623-199508000-0001910.2106/00004623-199508000-00019 ↗
19. M. Geetha et al., Prog. Mater. Sci. (2009). https://doi.org/10.1016/j.pmatsci.2008.06.00410.1016/j.pmatsci.2008.06.004 ↗
20. P. Frayssinet et al., Eur. J. Orthop. Surg. Traumatol. (1999). https://doi.org/10.1007/bf0169573710.1007/bf01695737 ↗
21. H. Gerengi, K. Ertuğrul, M. Cabrini, J. Adv. Technol. Sci. 6, 2 (2017)
22. S.D. Cramer, B.S. Covino, ASM Handbook Vol. 13 A Corrosion: Fundamentals, Testing, and Protection (ASM International, Materials Park, 2003), pp.96–19810.31399/asm.hb.v13a.9781627081825 ↗
23. L. Xu et al., J. Biomed. Mater. Res. A (2007). https://doi.org/10.1002/jbm.a.3127310.1002/jbm.a.31273 ↗
24. J.-C. Gao et al., Trans. Nonferrous Met. Soc. China (2008). https://doi.org/10.1016/S1003-6326(08)60102-810.1016/S1003-6326(08)60102-8 ↗
25. S. Cai et al., Mater. Sci. Eng. C (2012). https://doi.org/10.1016/j.msec.2012.07.04210.1016/j.msec.2012.07.042 ↗
26. B. Çiçek, Y. Sun, Mater. Des. (2012). https://doi.org/10.1016/j.matdes.2012.01.02910.1016/j.matdes.2012.01.029 ↗
27. E. Koç et al., J. Alloys Compds. (2015). https://doi.org/10.1016/j.jallcom.2015.06.22710.1016/j.jallcom.2015.06.227 ↗
28. S. Agarwal et al., Mater. Sci. Eng. C (2016). https://doi.org/10.1016/j.msec.2016.06.02010.1016/j.msec.2016.06.020 ↗
29. Y. Liu et al., Corros. Sci. (2019). https://doi.org/10.1016/j.corsci.2019.10818510.1016/j.corsci.2019.108185 ↗
30. N. Birbilis, R. Buchheit, J. Electrochem. Soc. (2008). https://doi.org/10.1149/1.282989710.1149/1.2829897 ↗
31. H. Jia, X. Feng, Y. Yang, Mater. Sci. Eng. C (2020). https://doi.org/10.1016/j.msec.2019.11001310.1016/j.msec.2019.110013 ↗
32. R.M. Pilliar, in Biomedical Materials. ed. by R. Narayan (Springer, Cham, 2021), pp.1–47
33. D. Chen et al., Int. J. Mol. Med. (2011). https://doi.org/10.3892/ijmm.2011.70710.3892/ijmm.2011.707 ↗
34. Z. Shi, M. Liu, A. Atrens, Corros. Sci. (2010). https://doi.org/10.1016/j.corsci.2009.10.01610.1016/j.corsci.2009.10.016 ↗
35. J. Fu et al., Biomaterials (2020). https://doi.org/10.1016/j.biomaterials.2019.11964110.1016/j.biomaterials.2019.119641 ↗
36. R.F. Wallin, MDDI: Los Angeles (1998)
37. R.F. Wallin, E. Arscott, Medical Device and Diagnostic Industry (1998)
38. D. Fischer et al., Biomaterials (2003). https://doi.org/10.1016/S0142-9612(02)00445-310.1016/S0142-9612(02)00445-3 ↗
39. J. Reifenrath et al., Mater, Werkst. (2010). https://doi.org/10.1002/mawe.20100070910.1002/mawe.201000709 ↗
40. E. Aghion, G. Levy, S. Ovadia, J. Mater. Sci. Mater. Med. (2012). https://doi.org/10.1007/s10856-011-4536-810.1007/s10856-011-4536-8 ↗
41. M.P. Staiger et al., Biomaterials (2006). https://doi.org/10.1016/j.biomaterials.2005.10.00310.1016/j.biomaterials.2005.10.003 ↗
42. G. Manivasagam, D. Dhinasekaran, A. Rajamanickam, Recent Pat. Corros. Sci. (2010). https://doi.org/10.2174/187761080100201004010.2174/1877610801002010040 ↗
43. F. Witte et al., J. Biomed. Mater. Res. A (2007). https://doi.org/10.1002/jbm.a.3117010.1002/jbm.a.31170 ↗
44. S. Johnston, M. Dargusch, A. Atrens, SCMs (2018). https://doi.org/10.1007/s40843-017-9173-710.1007/s40843-017-9173-7 ↗
45. M.F. Ulum et al., Coatings (2019). https://doi.org/10.3390/coatings905028210.3390/coatings9050282 ↗
46. D. Vojtech et al., Mater. Technol. (2015). https://doi.org/10.17222/mit.2014.12910.17222/mit.2014.129 ↗
47. H. Jiang et al., Mater. Sci. Eng. C (2017). https://doi.org/10.1016/j.msec.2017.03.01910.1016/j.msec.2017.03.019 ↗
48. L. Witting et al., Materialia (2020). https://doi.org/10.1016/j.mtla.2020.10094910.1016/j.mtla.2020.100949 ↗
49. B. Comba et al., Ankara Univ. Vet. Fac. J. 63, 3 (2016)
50. T. Karaca et al., Kafkas J. Med. Sci. (2013). https://doi.org/10.5505/kjms.2013.3685510.5505/kjms.2013.36855 ↗
51. B. Comba et al., Vet. Sci. Pract. (2014). https://doi.org/10.17094/avbd.4181610.17094/avbd.41816 ↗
52. C. Kilkenny et al., Br. J. Pharmacol. (2010). https://doi.org/10.1111/j.1476-5381.2010.00872.x10.1111/j.1476-5381.2010.00872.x ↗
53. A. Comba et al., Mater. Technol. (2022). https://doi.org/10.1080/10667857.2022.208111510.1080/10667857.2022.2081115 ↗
54. S. Zhang et al., Bioact. Mater. (2017). https://doi.org/10.1016/j.bioactmat.2017.03.00410.1016/j.bioactmat.2017.03.004 ↗
55. D. Noviana et al., JOT (2016). https://doi.org/10.1016/j.jot.2015.08.00310.1016/j.jot.2015.08.003 ↗
56. J. Gary, Am. J. Clin. Nutr. (1990). https://doi.org/10.1093/ajcn/51.2.22510.1093/ajcn/51.2.225 ↗
57. F. Witte et al., Biomaterials (2006). https://doi.org/10.1016/j.biomaterials.2005.07.03710.1016/j.biomaterials.2005.07.037 ↗
58. N.I.Z. Abidin et al., Corros. Sci. (2013). https://doi.org/10.1016/j.corsci.2013.06.01910.1016/j.corsci.2013.06.019 ↗
59. J. Tkacz et al., Metals (2017). https://doi.org/10.3390/met711046510.3390/met7110465 ↗
60. B. Mordike, T. Ebert, Mater. Sci. Eng. A (2001). https://doi.org/10.1016/S0921-5093(00)01351-410.1016/S0921-5093(00)01351-4 ↗
61. E. Koç, An investigation on corrosion dependent mechanical behaviours of biodegradable magnesium alloys. (Karabuk, Karabuk University, Institute of Science and Technology, 2013)
62. U.T. Seyfert, V. Biehl, J. Schenk, Biomol. Eng. (2002). https://doi.org/10.1016/S1389-0344(02)00015-110.1016/S1389-0344(02)00015-1 ↗
63. E. Ostertagova, O. Ostertag, J. Kováč, AMM (2014). https://doi.org/10.4028/www.scientific.net/AMM.611.11510.4028/www.scientific.net/AMM.611.115 ↗
64. A. Dinno, Stata J. (2015). https://doi.org/10.1177/1536867X150150011710.1177/1536867X1501500117 ↗
65. Y.S. Park et al., AAPS J. (2013). https://doi.org/10.1208/s12248-012-9442-610.1208/s12248-012-9442-6 ↗