Application of conventional spray dryer to prepare nanosilica-alginate based rhodamine loaded microstructures and nanobeads
Source abstract
Abstract
The applicability of conventional spray dryer was studied to prepare micro as well as nano carriers. Using spray drying technique rhodamine B (RhB) loaded nanosilica-sodium alginate microstructures (RhB-microstructures) was prepared. For the preparation of nanobeads, nozzle (atomizer) of spray dryer was used to spray the feed comprising RhB-nanosilica-sodium alginate in the calcium chloride solution and RhB loaded nanosilica-calcium alginate nanobeads (RhB-nanobeads) were obtained. Prepared carriers (RhB-microstructures and RhB-nanobeads) were characterized using SEM, FTIR, DLS and Zeta potential techniques. The flowability of prepared carriers were studied using compressibility index (C.I.) and Hausner ratio (H.R.). RhB-microstructures showed a higher loading efficiency 98.6% in comparison to 46.7% of RhB-nanobeads. In vitro release study demonstrated slow and pH-responsive release of RhB from nanobeads. Present study shows the applicability of conventional spray drying and use of spraying nozzle of conventional spray dryer to prepare microstructures and nanobeads, respectively.Graphical abstractThe application of conventional spray dryer to prepare micro and nano carriers.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Drug Solubulity and Delivery Systems · Microencapsulation and Drying Processes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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