The influence of the polyol solvents on the continuous growth of water-dispersible iron oxide nanoparticles
Source abstract
Abstract
Abstract Magnetic nanoparticles have continued to gain significant attention due to their unique magnetic properties and potential applications. However, it is still challenging to directly synthesize water-dispersible magnetic nanoparticles with controlled size for biomedical applications. This study investigates the influence of solvents on the continuous growth of magnetic nanoparticles, aiming to achieve controlled size and excellent water dispersibility via thermal decomposition in polyol solvents. The size of the nanoparticles gradually increases with longer polyol chain solvents. The increase in nanoparticles size is more significant under a higher reaction temperature (220 °C) compared to a lower temperature (190 °C). These monodispersed nanoparticles exhibit strong superparamagnetic properties, improving with longer solvent chain lengths at the same size. Magnetic resonance imaging (MRI) studies reveal higher relaxivities for magnetic nanoparticles synthesized in longer-chain polyols. This research offers valuable insights for synthesizing magnetic nanoparticles with precise sizes, magnetic properties, and biomedical applications. Graphical abstract
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Iron oxide chemistry and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. W. Xie, Z. Guo, F. Gao, Q. Gao, D. Wang, B.-S. Liaw, Q. Cai, X. Sun, X. Wang, L. Zhao, Shape-, size-and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics. Theranostics 8, 3284 (2018)10.7150/thno.25220 ↗
2. S.D. Topel, Ö. Topel, R.B. Bostancıoğlu, A.T. Koparal, Synthesis and characterization of Bodipy functionalized magnetic iron oxide nanoparticles for potential bioimaging applications. Colloids Surf., B 128, 245–253 (2015)10.1016/j.colsurfb.2015.01.043 ↗
3. A. Marcu, S. Pop, F. Dumitrache, M. Mocanu, C. Niculite, M. Gherghiceanu, C. Lungu, C. Fleaca, R. Ianchis, A. Barbut, Magnetic iron oxide nanoparticles as drug delivery system in breast cancer. Appl. Surf. Sci. 281, 60–65 (2013)10.1016/j.apsusc.2013.02.072 ↗
4. X.-L. Huang, Hydrolysis of phosphate esters catalyzed by inorganic iron oxide nanoparticles acting as biocatalysts. Astrobiology 18, 294–310 (2018)10.1089/ast.2016.1628 ↗
5. L. Wang, P. Hu, H. Jiang, J. Zhao, J. Tang, D. Jiang, J. Wang, J. Shi, W. Jia, Mild hyperthermia-mediated osteogenesis and angiogenesis play a critical role in magnetothermal composite-induced bone regeneration. Nano Today 43, 101401 (2022)10.1016/j.nantod.2022.101401 ↗
6. S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. Vander Elst, R.N. Muller, Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem. Rev. 108, 2064–2110 (2008)10.1021/cr068445e ↗
7. J. Park, J. Joo, S.G. Kwon, Y. Jang, T. Hyeon, Synthesis of monodisperse spherical nanocrystals. Angew. Chem. Int. Ed. 46, 4630–4660 (2007)10.1002/anie.200603148 ↗
8. J.-H. Lee, Y.-M. Huh, Y.-W. Jun, J.-W. Seo, J.-T. Jang, H.-T. Song, S. Kim, E.-J. Cho, H.-G. Yoon, J.-S. Suh, J. Cheon, Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat. Med. 13, 95–99 (2007)10.1038/nm1467 ↗
9. B.H. Kim, N. Lee, H. Kim, K. An, Y.I. Park, Y. Choi, K. Shin, Y. Lee, S.G. Kwon, H.B. Na, J.-G. Park, T.-Y. Ahn, Y.-W. Kim, W.K. Moon, S.H. Choi, T. Hyeon, Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T1 magnetic resonance imaging contrast agents. J. Am. Chem. Soc. 133, 12624–12631 (2011)10.1021/ja203340u ↗
10. H. Wei, O.T. Bruns, M.G. Kaul, E.C. Hansen, M. Barch, A. Wiśniowska, O. Chen, Y. Chen, N. Li, S. Okada, J.M. Cordero, M. Heine, C.T. Farrar, D.M. Montana, G. Adam, H. Ittrich, A. Jasanoff, P. Nielsen, M.G. Bawendi, Exceedingly small iron oxide nanoparticles as positive MRI contrast agents. Proc. Natl. Acad. Sci. 114, 2325–2330 (2017)10.1073/pnas.1620145114 ↗
11. L.M. Bauer, S.F. Situ, M.A. Griswold, A.C.S. Samia, High-performance iron oxide nanoparticles for magnetic particle imaging–guided hyperthermia (hMPI). Nanoscale 8, 12162–12169 (2016)10.1039/C6NR01877G ↗
12. C. Lu, L. Han, J. Wang, J. Wan, G. Song, J. Rao, Engineering of magnetic nanoparticles as magnetic particle imaging tracers. Chem. Soc. Rev. 50(14), 8102–46 (2021)10.1039/D0CS00260G ↗
13. L. Babes, B.T. Denizot, G. Tanguy, J.J. Jeune, P. Jallet, Synthesis of iron oxide nanoparticles used as MRI contrast agents: a parametric study. J. Colloid Interface Sci. 212, 474–482 (1999)10.1006/jcis.1998.6053 ↗
14. J.-R. Jeong, S.-C. Shin, S.-J. Lee, J.-D. Kim, Magnetic properties of superparamagnetic γ-Fe2O3 nanoparticles prepared by coprecipitation technique. J. Magn. Magn. Mater. 286, 5–9 (2005)10.1016/j.jmmm.2004.09.129 ↗
15. J. Park, K. An, Y. Hwang, J.-G. Park, H.-J. Noh, J.-Y. Kim, J.-H. Park, N.-M. Hwang, T. Hyeon, Ultra-large-scale syntheses of monodisperse nanocrystals. Nat. Mater. 3, 891–895 (2004)10.1038/nmat1251 ↗
16. T. Zhang, J. Ge, Y. Hu, Y. Yin, A general approach for transferring hydrophobic nanocrystals into water. Nano Lett. 7, 3203–3207 (2007)10.1021/nl071928t ↗
17. N. Kohler, G.E. Fryxell, M. Zhang, A Bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents. J. Am. Chem. Soc. 126, 7206–7211 (2004)10.1021/ja049195r ↗
18. Y. Xu, Y. Qin, S. Palchoudhury, Y. Bao, Water-soluble iron oxide nanoparticles with high stability and selective surface functionality. Langmuir 27, 8990–8997 (2011)10.1021/la201652h ↗
19. W. Cai, J. Wan, Facile synthesis of superparamagnetic magnetite nanoparticles in liquid polyols. J. Colloid Interface Sci. 305, 366–370 (2007)10.1016/j.jcis.2006.10.023 ↗
20. J. Wan, W. Cai, X. Meng, E. Liu, Monodisperse water-soluble magnetite nanoparticles prepared by polyol process for high-performance magnetic resonance imaging. Chem. Commun. 47, 5004–5006 (2007)10.1039/b712795b ↗
21. H. Dong, Y.C. Chen, C. Feldmann, Polyol synthesis of nanoparticles: status and options regarding metals, oxides, chalcogenides, and non-metal elements. Green Chem. 17, 4107–4132 (2015)10.1039/C5GC00943J ↗
22. R. Hachani, M. Lowdell, M. Birchall, A. Hervault, D. Mertz, S. Begin-Colin, N.T.K. Thanh, Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. Nanoscale 8, 3278–3287 (2016)10.1039/C5NR03867G ↗
23. P. Cheah, T. Cowan, R. Zhang, A. Fatemi-Ardekani, Y. Liu, J. Zheng, F. Han, Y. Li, D. Cao, Y. Zhao, Continuous growth phenomenon for direct synthesis of monodisperse water-soluble iron oxide nanoparticles with extraordinarily high relaxivity. Nanoscale 12, 9272–9283 (2020)10.1039/D0NR01552K ↗
24. P. Cheah, P. Brown, J. Qu, B. Tian, D.L. Patton, Y. Zhao, Versatile surface functionalization of water-dispersible iron oxide nanoparticles with precisely controlled sizes. Langmuir 37, 1279–1287 (2021)10.1021/acs.langmuir.0c03314 ↗
25. P. Cheah, J. Qu, Y. Li, D. Cao, X. Zhu, Y. Zhao, The key role of reaction temperature on a polyol synthesis of water-dispersible iron oxide nanoparticles. J. Magn. Magn. Mater. 540, 168481 (2021)10.1016/j.jmmm.2021.168481 ↗
26. Z. Cheng, X. Chu, H. Zhong, J. Yin, Y. Zhang, J. Xu, Synthesis of Fe3O4 nanoflowers by a simple and novel solvothermal process. Mater. Lett. 76, 90–92 (2012)10.1016/j.matlet.2012.02.062 ↗
27. E.C. Vreeland, J. Watt, G.B. Schober, B.G. Hance, M.J. Austin, A.D. Price, B.D. Fellows, T.C. Monson, N.S. Hudak, L. Maldonado-Camargo, A.C. Bohorquez, C. Rinaldi, D.L. Huber, Enhanced nanoparticle size control by extending LaMer’s mechanism. Chem. Mater. 27, 6059–6066 (2015)10.1021/acs.chemmater.5b02510 ↗
28. F. Fiévet, S. Ammar-Merah, R. Brayner, F. Chau, M. Giraud, F. Mammeri, J. Peron, J.Y. Piquemal, L. Sicard, G. Viau, The polyol process: a unique method for easy access to metal nanoparticles with tailored sizes, shapes and compositions. Chem. Soc. Rev. 47, 5187–5233 (2018)10.1039/C7CS00777A ↗
29. F.J. Douglas, D.A. MacLaren, M. Murrie, A study of the role of the solvent during magnetite nanoparticle synthesis: tuning size, shape and self-assembly. RSC Adv. 2, 8027–8035 (2012)10.1039/c2ra20494k ↗
30. L.T. Lu, N.T. Dung, L.D. Tung, C.T. Thanh, O.K. Quy, N.V. Chuc, S. Maenosono, N.T.K. Thanh, Synthesis of magnetic cobalt ferrite nanoparticles with controlled morphology, monodispersity and composition: the influence of solvent, surfactant, reductant and synthetic conditions. Nanoscale 7, 19596–19610 (2015)10.1039/C5NR04266F ↗
31. S. Chaki, T.J. Malek, M. Chaudhary, J. Tailor, M. Deshpande, Magnetite Fe3O4 nanoparticles synthesis by wet chemical reduction and their characterization. Adv. Nat. Sci. 6, 035009 (2015)
32. A. Guleria, P. Pranjali, M.K. Meher, A. Chaturvedi, S. Chakraborti, R. Raj, K.M. Poluri, D. Kumar, Effect of polyol chain length on proton relaxivity of gadolinium oxide nanoparticles for enhanced magnetic resonance imaging contrast. J. Phys. Chem. C 123, 18061–18070 (2019)10.1021/acs.jpcc.9b04089 ↗
33. K. Woo, J. Hong, S. Choi, H.-W. Lee, J.-P. Ahn, C.S. Kim, S.W. Lee, Easy synthesis and magnetic properties of iron oxide nanoparticles. Chem. Mater. 16, 2814–2818 (2004)10.1021/cm049552x ↗
34. K.H. Ngoi, J.C. Wong, W.S. Chiu, C.H. Chia, K.S. Jin, H.-J. Kim, H.-C. Kim, M. Ree, Morphological structure details, size distributions and magnetic properties of iron oxide nanoparticles. J. Ind. Eng. Chem. 95, 37–50 (2021)10.1016/j.jiec.2020.11.027 ↗
35. H. Kahil, A. Faramawy, H. El-Sayed, A. Abdel-Sattar, Magnetic properties and SAR for gadolinium-doped iron oxide nanoparticles prepared by hydrothermal method. Crystals 11, 1153 (2021)10.3390/cryst11101153 ↗