Efficacy of photodynamic therapy using UVB radiation-emitting novel phosphor material for non-surgical treatment of psoriasis
Source abstract
Abstract
Ultraviolet (UV) light is the key to treat various skin conditions effectively. Commercial UV lamps emit a broad spectrum (width > 100 nm) and are widely used to treat skin diseases. Psoriasis is a non-contagious long-term skin infection that affects many people worldwide. Only a small part of the UV light spectrum is required for skin rejuvenation, which corresponds to action spectrum of psoriasis. However, the use of broadband emitting commercial UV light leads to side effects such as skin tanning, erythema, etc. To avoid this issue, a series of UV emitting Ca2MgSi2O7:Gd3+phosphors that have a specific narrow wavelength range were prepared for the first time with promising results in the field of dermatology. The optimized Ca2-xMgSi2O7:xGd3+phosphor had an intensity comparable to commercial LaPO4:Ce3+phosphor (UVB-315), making the developed phosphor a promising option for the effective treatment of psoriasis in fewer lesions with minimal risk of erythema.Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: bioluminescence and chemiluminescence research · Photodynamic Therapy Research Studies · Psoriasis: Treatment and Pathogenesis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (49)
Show source-provided references
1. A.O. Chauhan, A.B. Gawande, S.K. Omanwar, Narrow band UVB emitting phosphor LaPO4:Gd3+ for phototherapy lamp. Optik (Stuttg) 127, 6647–6652 (2016). https://doi.org/10.1016/j.ijleo.2016.04.13110.1016/j.ijleo.2016.04.131 ↗
2. K. Danielsen, A.O. Olsen, T. Wilsgaard et al., Is the prevalence of psoriasis increasing?-A 30 year follow-up of a population-based cohort. Br J Dermatol 168, 1303–1310 (2013). https://doi.org/10.1111/bjd.1223010.1111/bjd.12230 ↗
3. S. Gibbs, Skin disease and socioeconomic conditions in rural Africa: Tanzania. Int J Dermatol 35, 633–639 (1996). https://doi.org/10.1111/j.1365-4362.1996.tb03687.x10.1111/j.1365-4362.1996.tb03687.x ↗
4. A. Rendon, K. Schäkel, Psoriasis pathogenesis and treatment. Int J Mol Sci 20, 1475 (2019). https://doi.org/10.3390/ijms2006147510.3390/ijms20061475 ↗
5. T.R. Matos, T.C. Ling, V. Sheth, Ultraviolet B radiation therapy for psoriasis: pursuing the optimal regime. Clin Dermatol 34, 587–593 (2016). https://doi.org/10.1016/j.clindermatol.2016.05.00810.1016/j.clindermatol.2016.05.008 ↗
6. H.J. Vreman, R.J. Wong, D.K. Stevenson, Phototherapy: current methods and future directions. Semin Perinatol 28, 326–333 (2004). https://doi.org/10.1053/j.semperi.2004.09.00310.1053/j.semperi.2004.09.003 ↗
7. A. Menter, N.J. Korman, C.A. Elmets et al., Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 62, 114–135 (2010). https://doi.org/10.1016/j.jaad.2009.08.02610.1016/j.jaad.2009.08.026 ↗
8. M. Nimbalkar, M. Yawalkar, N. Mahajan, S.J. Dhoble, Potential of luminescent materials in phototherapy. Photodiagnosis Photodyn Ther 33, 102082 (2021). https://doi.org/10.1016/j.pdpdt.2020.10208210.1016/j.pdpdt.2020.102082 ↗
9. D. Popa, R. Hopper, S.Z. Ali et al., A highly stable, nanotube-enhanced, CMOS-MEMS thermal emitter for mid-IR gas sensing. Sci Rep 11, 22915 (2021). https://doi.org/10.1038/s41598-021-02121-510.1038/s41598-021-02121-5 ↗
10. T.G.V.M. Rao, A.R. Kumar, N. Veeraiah, M.R. Reddy, Optical and structural investigation of Sm3+-Nd3+ co-doped in magnesium lead borosilicate glasses. J Phys Chem Solids 74, 410–417 (2013). https://doi.org/10.1016/j.jpcs.2012.11.00210.1016/j.jpcs.2012.11.002 ↗
11. Y. Pan, Effects of Cu, Ag and Au on electronic and optical properties of α-Ga2O3 oxide according to first-principles calculations. J Phys Chem Solids 174, 111152 (2023). https://doi.org/10.1016/j.jpcs.2022.11115210.1016/j.jpcs.2022.111152 ↗
12. S. Sharma, S.K. Dubey, A.K. Diwakar, S. Pandey, Structural characterization and luminescence properties of Ca2MgSi2O7 (CMS) phosphor. Int J Sci Res Res Pap Phys Appl Sci 9, 49–53 (2021). https://doi.org/10.1007/s11164-015-1929-110.1007/s11164-015-1929-1 ↗
13. Y. Pan, First-principles investigation of the influence of point defect on the electronic and optical properties of α-Ga2O3. Intl J Energy Res 46, 13070–13078 (2022). https://doi.org/10.1002/er.804710.1002/er.8047 ↗
14. Y. Pan, First-principles investigation of structural stability, electronic and optical properties of suboxide (Zr3O). Mater Sci Eng B 281, 115746 (2022). https://doi.org/10.1016/j.mseb.2022.11574610.1016/j.mseb.2022.115746 ↗
15. H. Yang, R.M. Hazen, R.T.L.W. DownsFinger, Structural change associated with the incommensurate-normal phase transition in akermanite, Ca2MgSi2O7, at high pressure. Phys chem Miner 24, 510–519 (1997). https://doi.org/10.1007/s00269005006610.1007/s002690050066 ↗
16. L. Zhou, R. Ye, F. Liu et al., Dual-emitting from Bi3+/Eu3+ co-activated akermanite phosphor for optical thermometric applications. Opt Mater (Amst) 116, 111076 (2021). https://doi.org/10.1016/j.optmat.2021.11107610.1016/j.optmat.2021.111076 ↗
17. S.K. Zand, S. Baghshahi, M. Rajabi, The effect of Eu and Dy dopants on the luminescence properties of Sr4Al14O25:Eu2+, Dy3+ phosphorescent nano-pigments prepared by the solution combustion method. J Mater Sci Mater Electron 27, 12533–12538 (2016). https://doi.org/10.1007/s10854-016-5787-410.1007/s10854-016-5787-4 ↗
18. Y. Pan, First-principles investigation of the effect of noble metals on the electronic and optical properties of GaN nitride. Mater Sci Semicond Process 151, 107051 (2022). https://doi.org/10.1016/j.mssp.2022.10705110.1016/j.mssp.2022.107051 ↗
19. Z.C. Wu, L.N. Yang, J. Liu et al., Luminescent properties of Eu2+ in BaCdP2O7: Eu2+ phosphor: experimental and theoretical analysis. Dye Pigment 149, 158–166 (2018). https://doi.org/10.1016/j.dyepig.2017.09.06510.1016/j.dyepig.2017.09.065 ↗
20. M. Pal, U. Pal, J.M.G.Y. Jiménez, F. Pérez-Rodríguez, Effects of crystallization and dopant concentration on the emission behavior of TiO 2: Eu nanophosphors. Nanoscale Res Lett 7, 1–12 (2012). https://doi.org/10.1186/1556-276X-7-110.1186/1556-276X-7-1 ↗
21. J.K. Sharda, S. Chawla, Synthesis of Mn doped ZnO nanoparticles with biocompatible capping. Appl Surf Sci 256, 2630–2635 (2010). https://doi.org/10.1016/j.apsusc.2009.11.00810.1016/j.apsusc.2009.11.008 ↗
22. T. Yu, F. Zhong, F. Zhang et al., Application of scanning electron microscopy in metal material detection. J Phys Conf Ser 2002, 012010 (2021). https://doi.org/10.1088/1742-6596/2002/1/01201010.1088/1742-6596/2002/1/012010 ↗
23. M. Rakshita, A. Babu, K. Jayanthi et al., Studies on contact angle measurements in superoleophobic aluminum hydroxide nanoflakes. Mater Lett 315, 131938 (2022). https://doi.org/10.1016/j.matlet.2022.13193810.1016/j.matlet.2022.131938 ↗
24. Y. Pan, First-principles investigation of structural, electronic, and optical properties of transition metal-doped C40 CrSi2. Int J Quantum Chem 120, 1–7 (2020). https://doi.org/10.1002/qua.2640110.1002/qua.26401 ↗
25. T. Dubroca, K. Moyant, R.E. Hummel, Ultra-violet and visible absorption characterization of explosives by differential reflectometry. Spectrochim Acta Part A Mol Biomol Spectrosc 105, 149–155 (2013). https://doi.org/10.1016/j.saa.2012.11.09010.1016/j.saa.2012.11.090 ↗
26. T. Jan, S. Azmat, B. Wahid et al., Chemically synthesized ZnO-Bi2O3 (BZO) nanocomposites with tunable optical, photoluminescence, and antibacterial characteristics. Mater Sci Semicond Process 84, 71–75 (2018). https://doi.org/10.1016/j.mssp.2018.05.00710.1016/j.mssp.2018.05.007 ↗
27. L. Cao, W. Weng, X. Chen et al., Effects of mesoporous calcium magnesium silicate on setting time, compressive strength, apatite formation, degradability and cell behavior to magnesium phosphate-based bone cement. RSC Adv 7, 870–879 (2017). https://doi.org/10.1039/c6ra25503e10.1039/c6ra25503e ↗
28. X. Chen, M. Yang, Y. Cheng et al., Narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen-ultraviolet A photochemotherapy for psoriasis. Cochrane Database Syst Rev 2013, CD009481 (2013). https://doi.org/10.1002/14651858.CD009481.pub210.1002/14651858.CD009481.pub2 ↗
29. Z. Fu, S. Zhou, S. Zhang, Study on optical properties of rare-earth ions in nanocrystalline monoclinic SrAl2O4: Ln (Ln = Ce3+, Pr 3+, Tb3+). J Phys Chem B 109, 14396–14400 (2005). https://doi.org/10.1021/jp051313p10.1021/jp051313p ↗
30. D.S. Thakare, S.K. Omanwar, P.L. Muthal et al., UV-emitting phosphors: synthesis, photoluminescence and applications. Phys Status Solidi Appl Res 201, 574–581 (2004). https://doi.org/10.1002/pssa.20030672010.1002/pssa.200306720 ↗
31. T. Deng, S. Yan, J. Hu, A novel narrow band UV-B emitting phosphor-YPO4:Sb3+, Gd3+. J Rare Earths 34, 137–142 (2016). https://doi.org/10.1016/S1002-0721(16)60005-410.1016/S1002-0721(16)60005-4 ↗
32. M.A. Sadovnikova, F.F. Murzakhanov, I.V. Fadeeva et al., Study of tricalcium phosphate ceramics doped with gadolinium ions with various EPR techniques. Ceramics 5, 1154–1166 (2022). https://doi.org/10.3390/ceramics504008110.3390/ceramics5040081 ↗
33. V. Singh, N. Singh, M.S. Pathak, V. Natarajan, Development of UVB radiation-emitting Gd3+-doped Na3YSi2O7 host material. J Electron Mater 48, 1498–1505 (2019). https://doi.org/10.1007/s11664-018-06884-y10.1007/s11664-018-06884-y ↗
34. Y. Zhang, J. Xu, B.B. Yang et al., Luminescence properties and energy migration mechanism of Eu3+ activated Bi4Si3O12 as a potential phosphor for white LEDs. Mater Res Express 5, 2053–1591 (2018). https://doi.org/10.1088/2053-1591/aaab8a10.1088/2053-1591/aaab8a ↗
35. Y. Pan, E. Yu, First-principles investigation of electronic and optical properties of H-doped FeS2. Int J Energy Res 45, 11284–11293 (2021). https://doi.org/10.1002/er.651010.1002/er.6510 ↗
36. M.Y.A. Yagoub, H.C. Swart, E. Coetsee, Concentration quenching, surface and spectral analyses of SrF2:Pr3+ prepared by different synthesis techniques. Opt Mater (Amst) 42, 204–209 (2015). https://doi.org/10.1016/j.optmat.2015.01.01110.1016/j.optmat.2015.01.011 ↗
37. D. Gao, Y. Li, L. Cheng et al., Concentration effects of fluorescence quenching and optical transition properties of Dy3+ doped NaYF4 phosphor. J Alloys Compd 895, 162616 (2022). https://doi.org/10.1016/j.jallcom.2021.16261610.1016/j.jallcom.2021.162616 ↗
38. P.S. Hemne, R.G. Kunghatkar, S.J. Dhoble et al., Phosphor for phototherapy: review on psoriasis. Luminescence 32, 260–270 (2017). https://doi.org/10.1002/bio.326610.1002/bio.3266 ↗
39. A. Ferahbas, H. Donmez-Altuntas, Z. Hamurcu et al., Micronucleus evaluation in mitogen-stimulated lymphocytes of narrow-band (311 nm TL01) UVB-treated patients. Photodermatol Photoimmunol Photomed 20, 81–85 (2004). https://doi.org/10.1111/j.1600-0781.2004.00086.x10.1111/j.1600-0781.2004.00086.x ↗
40. K. Storbeck, E. Hölzle, N. Schürer et al., Narrow-band UVB (311 nm) versus conventional broad-band UVB with and without dithranol in phototherapy for psoriasis. J Am Acad Dermatol 28, 227–231 (1993). https://doi.org/10.1016/0190-9622(93)70032-O10.1016/0190-9622(93)70032-O ↗
41. S.M. Kirke, S. Lowder, J.J. Lloyd et al., A randomized comparison of selective broadband UVB and narrowband UVB in the treatment of psoriasis. J Invest Dermatol 127, 1641–1646 (2007). https://doi.org/10.1038/sj.jid.570076710.1038/sj.jid.5700767 ↗
42. P.A. Nagpure, S.K. Omanwar, Synthesis and photoluminescence study of rare earth activated phosphor Na2La2B2O7. J Lumin 132, 2088–2091 (2012). https://doi.org/10.1016/j.jlumin.2012.03.06810.1016/j.jlumin.2012.03.068 ↗
43. S.P. Bhagat, A.B. Gawande, S.K. Omanwar, Photoluminescence study of a novel UV emitting phosphor Sr2Mg(BO3)2:Pb2+, Gd3+. Opt Mater (Amst) 40, 36–40 (2015). https://doi.org/10.1016/j.optmat.2014.11.04310.1016/j.optmat.2014.11.043 ↗
44. P.A. Nagpure, S.K. Omanwar, UV emitting borate phosphors for phototherapy lamps. Indian J Pure Appl Phys 53, 77–81 (2015). https://doi.org/10.56042/ijpap.v53i2.571110.56042/ijpap.v53i2.5711 ↗
45. R.G. Kunghatkar, P.S. Hemne, S.J. Dhoble, UVB emitting LiSrBO3 phosphor for phototherapy lamp. AIP Conf Proc 1953, 080038-1-080038–5 (2018). https://doi.org/10.1063/1.503284410.1063/1.5032844 ↗
46. N. de Moura Barros, L.L. Sbroglio, M. de Oliveira Buffara et al., Phototherapy. An Bras Dermatol 96, 397–407 (2021). https://doi.org/10.1016/j.abd.2021.03.00110.1016/j.abd.2021.03.001 ↗
47. S.C. Weatherhead, P.M. Farr, N.J. Reynolds, Spectral effects of UV on psoriasis. Photochem Photobiol Sci 12, 47–53 (2013). https://doi.org/10.1039/c2pp25116g10.1039/c2pp25116g ↗
48. D.G. Fortune, H.L. Richards, B. Kirby et al., Psychological distress impairs clearance of psoriasis in patients treated with photochemotherapy. Arch Dermatol 139, 752–756 (2003). https://doi.org/10.1001/archderm.139.6.75210.1001/archderm.139.6.752 ↗
49. X. Yang, X. Wang, Y. Feng et al., Removal of multifold heavy metal contaminations in drinking water by porous magnetic Fe2O3@AlO(OH) superstructure. J Mater Chem A 1, 473–477 (2013). https://doi.org/10.1039/c2ta00594h10.1039/c2ta00594h ↗