Electroactive nanofibrous scaffold based on polythiophene for bone tissue engineering application
Source abstract
Abstract
Electrically conductive polymeric biomaterials are promising candidates for bone tissue engineering (TE) due to pivotal role of electrical stimulation (ES) in regulating of some biological functions, including cells adhesion, migration and differentiation, as well as DNA synthesis. Herein, we have designed and developed a conductive nanofibrous scaffold composed of poly(vinyl amine) (PVAm), polythiophene (PTh), and poly(ε-caprolactone) (PCL), and its performance in bone TE was preliminary investigated in terms of some physicochemical as well as biological properties. Electrical conductivity of the produced scaffold was determined as 5.7 × 10–3Scm−1. The fabricated scaffold in acidic condition exhibited higher biodegradation rate (pH 4.2; 40.1 wt%) than the physiological condition (PBS; pH 7.4; 33.6 wt%). MTT assay results revealed that the fabricated scaffold has an acceptable biocompatibility and can improve the cells adhesion as well as proliferation that qualified it for a successful TE process.Graphical abstractNanofibrous electrically conductive scaffold composed of poly(vinyl amine) (PVAm), polythiophene (PTh), and poly(ε-caprolactone) (PCL) was developed through electrospinning technique, and its performance in bone TE was preliminary investigated in terms of some physicochemical as well as biological features.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (43)
Show source-provided references
1. S. Bose, M. Roy, A. Bandyopadhyay, Recent advances in bone tissue engineering scaffolds. Trends Biotechnol. 30(10), 546 (2012)10.1016/j.tibtech.2012.07.005 ↗
2. F.J. O’Brien, Biomaterials & scaffolds for tissue engineering. Mater. Today 14(3), 88 (2011)10.1016/S1369-7021(11)70058-X ↗
3. S. Van Vlierberghe, P. Dubruel, E. Schacht, Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. Biomacromol 12(5), 1387 (2011)10.1021/bm200083n ↗
4. M.N. Rahaman, D.E. Day, B. Sonny Bal, Q. Fu, S.B. Jung, L.F. Bonewald, A.P. Tomsia, Bioactive glass in tissue engineering. Acta Biomater. 7(6), 2355 (2011)10.1016/j.actbio.2011.03.016 ↗
5. H. Samadian, H. Maleki, A. Fathollahi, M. Salehi, S. Gholizadeh, H. Derakhshankhah, Z. Allahyari, M. Jaymand, Naturally occurring biological macromolecules-based hydrogels: potential biomaterials for peripheral nerve regeneration. Int. J. Biol. Macromol. 154, 795 (2020)10.1016/j.ijbiomac.2020.03.155 ↗
6. M. Abbasian, B. Massoumi, R. Mohammad-Rezaei, H. Samadian, M. Jaymand, Scaffolding polymeric biomaterials: are naturally occurring biological macromolecules more appropriate for tissue engineering? Int. J. Biol. Macromol. 134, 673 (2019)10.1016/j.ijbiomac.2019.04.197 ↗
7. B. Massoumi, M. Hatamzadeh, N. Firouzi, M. Jaymand, Electrically conductive nanofibrous scaffold composed of poly(ethylene glycol)-modified polypyrrole and poly(ε-caprolactone) for tissue engineering applications. Mater. Sci. Eng. C 98, 300 (2019)10.1016/j.msec.2018.12.114 ↗
8. B. Massoumi, M. Abbasian, R. Jahanban-Esfahlan, R. Mohammad-Rezaei, B. Khalilzadeh, H. Samadian, A. Rezaei, H. Derakhshankhah, M. Jaymand, A novel bio-inspired conductive, biocompatible, and adhesive terpolymer based on polyaniline, polydopamine, and polylactide as scaffolding biomaterial for tissue engineering application. Int. J. Biol. Macromol. 147, 1174 (2020)10.1016/j.ijbiomac.2019.10.086 ↗
9. V. Karageorgiou, D. Kaplan, Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26(27), 5474 (2005)10.1016/j.biomaterials.2005.02.002 ↗
10. S.J. Hollister, Porous scaffold design for tissue engineering. Nat. Mater. 4(7), 518 (2005)10.1038/nmat1421 ↗
11. T.J. Sill, H.A. von Recum, Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29(13), 1989 (2008)10.1016/j.biomaterials.2008.01.011 ↗
12. S.A. Sell, M.J. McClure, K. Garg, P.S. Wolfe, G.L. Bowlin, Electrospinning of collagen/biopolymers for regenerative medicine and cardiovascular tissue engineering. Adv. Drug Del. Rev. 61(12), 1007 (2009)10.1016/j.addr.2009.07.012 ↗
13. S. Vandghanooni, M. Eskandani, Natural polypeptides-based electrically conductive biomaterials for tissue engineering. Int. J. Biol. Macromol. 147, 706 (2020)10.1016/j.ijbiomac.2019.12.249 ↗
14. L. Ghasemi-Mobarakeh, M.P. Prabhakaran, M. Morshed, M.H. Nasr-Esfahani, H. Baharvand, S. Kiani, S.S. Al-Deyab, S. Ramakrishna, Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering. J. Tissue Eng. Regener. Med. 5(4), e17 (2011)10.1002/term.383 ↗
15. S. Vandghanooni, M. Eskandani, Electrically conductive biomaterials based on natural polysaccharides: challenges and applications in tissue engineering. Int. J. Biol. Macromol. 141, 636 (2019)10.1016/j.ijbiomac.2019.09.020 ↗
16. P. Baei, M. Hosseini, H. Baharvand, S. Pahlavan, Electrically conductive materials for in vitro cardiac microtissue engineering. J. Biomed. Mater. Res. Part A 108(5), 1203 (2020)10.1002/jbm.a.36894 ↗
17. E.N. Zare, P. Makvandi, B. Ashtari, F. Rossi, A. Motahari, G. Perale, Progress in conductive polyaniline-based nanocomposites for biomedical applications: a review. J. Med. Chem. 63(1), 1 (2020)10.1021/acs.jmedchem.9b00803 ↗
18. M. Tomczykowa, M.E. Plonska-Brzezinska, Conducting polymers, hydrogels and their composites: preparation, properties and bioapplications. Polymers 11(2), 350 (2019)10.3390/polym11020350 ↗
19. B. Guo, L. Glavas, A.C. Albertsson, Biodegradable and electrically conducting polymers for biomedical applications. Prog. Polym. Sci. 38(9), 1263 (2013)10.1016/j.progpolymsci.2013.06.003 ↗
20. T. Nezakati, A. Seifalian, A. Tan, A.M. Seifalian, Conductive polymers: opportunities and challenges in biomedical applications. Chem. Rev. 118(14), 6766 (2018)10.1021/acs.chemrev.6b00275 ↗
21. P. Zarrintaj, B. Bakhshandeh, M.R. Saeb, F. Sefat, I. Rezaeian, M.R. Ganjali, S. Ramakrishna, M. Mozafari, Oligoaniline-based conductive biomaterials for tissue engineering. Acta Biomater. 72, 16 (2018)10.1016/j.actbio.2018.03.042 ↗
22. J.H. Min, M. Patel, W.G. Koh, Incorporation of conductive materials into hydrogels for tissue engineering applications. Polymers 10(10), 1078 (2018)10.3390/polym10101078 ↗
23. T.-H. Le, Y. Kim, H. Yoon, Electrical and electrochemical properties of conducting polymers. Polymers 9(4), 150 (2017)10.3390/polym9040150 ↗
24. L.M. Cowen, J. Atoyo, M.J. Carnie, D. Baran, B.C. Schroeder, Organic materials for thermoelectric energy generation. ECS J. Solid State Sci. Technol. 6(3), N3080 (2017)10.1149/2.0121703jss ↗
25. S.M. Oliveira, N.M. Alves, J.F. Mano, Cell interactions with superhydrophilic and superhydrophobic surfaces. J. Adhes. Sci. Technol. 28(8–9), 843 (2014)10.1080/01694243.2012.697776 ↗
26. H.S. Yang, B. Lee, J.H. Tsui, J. Macadangdang, S.Y. Jang, S.G. Im, D.H. Kim, Electroconductive nanopatterned substrates for enhanced myogenic differentiation and maturation. Adv. Healthc. Mater. 5(1), 137 (2016)10.1002/adhm.201500003 ↗
27. A. Ito, Y. Yamamoto, M. Sato, K. Ikeda, M. Yamamoto, H. Fujita, E. Nagamori, Y. Kawabe, M. Kamihira, Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation. Sci. Rep. (2014). https://doi.org/10.1038/srep0478110.1038/srep04781 ↗
28. L. Hou, B. Hu, J. Jalife, Genetically engineered excitable cardiac myofibroblasts coupled to cardiomyocytes rescue normal propagation and reduce arrhythmia complexity in heterocellular monolayers. PLoS ONE (2013). https://doi.org/10.1371/journal.pone.005540010.1371/journal.pone.0055400 ↗
29. T. Ghassemi, A. Shahroodi, M.H. Ebrahimzadeh, A. Mousavian, J. Movaffagh, A. Moradi, Current concepts in scaffolding for bone tissue engineering. Arch. Bone Jt. Surg. 6(2), 90 (2018)
30. E.W.C. Chan, D. Bennet, P. Baek, D. Barker, S. Kim, J. Travas-Sejdic, Electrospun polythiophene phenylenes for tissue engineering. Biomacromol 19(5), 1456 (2018)10.1021/acs.biomac.8b00341 ↗
31. S. Wang, S. Guan, J. Wang, H. Liu, T. Liu, X. Ma, Z. Cui, Fabrication and characterization of conductive poly (3, 4-ethylenedioxythiophene) doped with hyaluronic acid/poly (L-lactic acid) composite film for biomedical application. J. Biosci. Bioeng. 123(1), 116 (2017)10.1016/j.jbiosc.2016.07.010 ↗
32. Y. Chen, X. Zheng, Y. Xie, C. Ding, H. Ruan, C. Fan, Anti-bacterial and cytotoxic properties of plasma sprayed silver-containing HA coatings. J. Mater. Sci.: Mater. Med. 19(12), 3603 (2008)
33. E. Armelin, A.L. Gomes, M.M. Pérez-Madrigal, J. Puiggalí, L. Franco, L.J. del Valle, A. Rodríguez-Galán, J.S.D.C. Campos, N. Ferrer-Anglada, C. Alemán, Biodegradable free-standing nanomembranes of conducting polymer: polyester blends as bioactive platforms for tissue engineering. J. Mater. Chem. 22(2), 585 (2012)10.1039/C1JM14168F ↗
34. D. Mawad, E. Stewart, D.L. Officer, T. Romeo, P. Wagner, K. Wagner, G.G. Wallace, A single component conducting polymer hydrogel as a scaffold for tissue engineering. Adv. Funct. Mater. 22(13), 2692 (2012)10.1002/adfm.201102373 ↗
35. M.M. Perez-Madrigal, M.I. Giannotti, L.J. del Valle, L. Franco, E. Armelin, J. Puiggalı́, F. Sanz, C. Aleman, Thermoplastic polyurethane: polythiophene nanomembranes for biomedical and biotechnological applications. ACS Appl. Mater. Interfaces 6(12), 9719 (2014)10.1021/am502150q ↗
36. H.A. Dewia, B.S. FangbenMengb, C. Guoa, B. Norlingc, X. Chenb, S. Lima: RSC Adv.
37. S. Moulton, K. Gilmore, G. Clark, G.G. Wallace, R. Breukers, D.L. Officer, M. Higgins, K. Wagner, R. Kapsa, M. Kita: Creating conductive structures for cell growth: growth and alignment of myogenic cell types on polythiophenes (2010)
38. B. Massoumi, M. Jaymand, Nanostructured star-shaped polythiophene with tannic acid core: synthesis, characterization, and its physicochemical properties. J. Appl. Polym. Sci. (2016). https://doi.org/10.1002/app.4351310.1002/app.43513 ↗
39. M. Hatamzadeh, P. Najafi-Moghadam, Y. Beygi-Khosrowshahi, B. Massoumi, M. Jaymand, Electrically conductive nanofibrous scaffolds based on poly(ethylene glycol)s-modified polyaniline and poly(ε-caprolactone) for tissue engineering applications. RSC Adv. 6(107), 105371 (2016)10.1039/C6RA22280C ↗
40. B. Massoumi, S. Davtalab, M. Jaymand, A.A. Entezami, AB2 Y-shaped miktoarm star conductive polyaniline-modified poly(ethylene glycol) and its electrospun nanofiber blend with poly(ε-caprolactone). RSC Adv. 5(46), 36715 (2015)10.1039/C5RA02926K ↗
41. M. Zamanlu, M. Eskandani, J. Barar, M. Jaymand, P.S. Pakchin, M. Farhoudi, Enhanced thrombolysis using tissue plasminogen activator (tPA)-loaded PEGylated PLGA nanoparticles for ischemic stroke. J. Drug Del. Sci. Technol. (2019). https://doi.org/10.1016/j.jddst.2019.10116510.1016/j.jddst.2019.101165 ↗
42. M.B. Bahadori, M. Eskandani, M. De Mieri, M. Hamburger, H. Nazemiyeh, Anti-proliferative activity-guided isolation of clerodermic acid from Salvia nemorosa L.: geno/cytotoxicity and hypoxia-mediated mechanism of action. Food Chem. Toxicol. 120, 155 (2018)10.1016/j.fct.2018.06.060 ↗
43. A. Ehterami, M. Salehi, S. Farzamfar, A. Vaez, H. Samadian, H. Sahrapeyma, M. Mirzaii, S. Ghorbani, A. Goodarzi, In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats model. Int. J. Biol. Macromol. 117, 601 (2018)10.1016/j.ijbiomac.2018.05.184 ↗