DataVXArtificial Cells, Nanomedicine, and BiotechnologyPaper
journal article·2017-11-17Open access

Conjugated anionic PEG-citrate G2 dendrimer with multi-epitopic HIV-1 vaccine candidate enhance the cellular immune responses in mice

Asghar Abdoli, Nina Radmehr, Azam Bolhassani, Akram Eidi, Parvaneh Mehrbod, Fatemeh Motevalli, Zahra Kianmehr, Mohsen Chiani, Mehdi Mahdavi, Shaghayegh Yazdani, Mehdi Shafiee Ardestani, Mohammad Reza Kandi, Mohammad Reza Aghasadeghi

Artificial Cells, Nanomedicine, and Biotechnology· Volume 45· Issue 8
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Source abstract

Abstract

Multi-epitope vaccines might cause immunity against multiple antigenic targets. Four immunodominant epitopes of HIV-1 genome were used to construct a polytope vaccine, formulated by dendrimer. Two regimens of polytopes mixture with dendrimer were utilized to immunize BALB/c mice. Adjuvants were also used to boost immune responses. The conjugated polytope could arouse significant cellular immune responses (P < 0.05) and Th1 response showed higher intensity compared to Th2 (P < 0.05). Our study depicted that conjugated dendrimer with multi-epitopic rHIVtop4 would efficiently induce cell-mediated immune responses and might be considered as promising delivery system for vaccines formulation.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: RNA Interference and Gene Delivery · Immunotherapy and Immune Responses · HIV Research and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran;

Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran;

Influenza and Other Respiratory Viruses Department, Pasteur Institute of Iran, Tehran, Iran;

Immunoregulation Research Centre, Shahed University, Tehran, Iran;

Department of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran;

Department of Immunology, Pasteur Institute of Iran, Tehran, Iran;

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;

Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;

Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran

Funding

Iran National Science Foundation

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