A Comparative Study on the Degradation Properties of Mg Wire/Poly(lactic acid) Composite Rods: Influence of Rod Diameter
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Abstract
Abstract A comparative study on the degradation properties of fully biodegradable Mg wire/poly(lactic acid) (PLA) composite rods with rod diameter of 5 mm and 6 mm (Φ5-HP and Φ6-HP) at the same Mg wire volume content was performed. Control groups of PLA rods with the same diameter (Φ5-PLA and Φ6-PLA) were also studied. The results indicated the sample diameter significantly influenced the degradation performance. For Φ5-HP, after 3-week immersion, the pH value of immersion fluid, the mass loss rate and bending strength decline of the sample was 9.3, 22.3 and 26.8%, respectively, while the viscosity-average molecular weight of PLA matrix decreased to 3.65 × 104 g/mol with a decline amplitude of 36.0%. The changes in Φ5-HP were more obvious than those in Φ6-HP, indicating the faster degradation at a smaller diameter. According to the molecular dynamics simulation results after degradation for 1 week at 50 °C, the diffusion coefficients of H2O (DH2O) in Φ5-HP and Φ6-HP were 8.1 × 10−6 and 5.8 × 10−6 cm2/s, respectively. The DH2O in Φ5-PLA and Φ6-PLA was 2.6 × 10−5 and 1.9 × 10−5 cm2/s, respectively, while the DH2O of water itself was 1.5 × 10−4 cm2/s. The results clarified the influence mechanism of radial diffusion distance of degradation medium on degradation performances of the samples. Furthermore, the life cycle assessment method was used to calculate the carbon emission of Mg wire/PLA composite rods during their preparation and degradation process. Graphical Abstract
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Research context
OpenAlex topics: biodegradable polymer synthesis and properties · Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications
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References (36)
Show source-provided references
1. J.C. Middleton and A.J. Tipton, Synthetic Biodegradable Polymers as Orthopedic Devices, Biomaterials, 2000, 21, p 2335–2346.10.1016/S0142-9612(00)00101-0 ↗
2. J.W. Lee, H.S. Han, K.J. Han, J. Park, H. Jeon, M.R. Ok, H.K. Seok, J.P. Ahn, K.E. Lee, D.H. Lee, S.J. Yang, S.Y. Cho, P.R. Cha, H. Kwon, T.H. Nam, J.H.L. Han, H.J. Rho, K.S. Lee, Y.C. Kim and D. Mantovani, Long-Term Clinical Study and Multiscale Analysis of In Vivo Biodegradation Mechanism of Mg Alloy, PNAS, 2016, 113, p 716–721.10.1073/pnas.1518238113 ↗
3. H. Windhagen, K. Radtke, A. Weizbauer, J. Diekmann, Y. Nolll, U. Kreimeyer, R. Schavan, C.S. Colsman and H. Waizy, Biodegradable Magnesium-Based Screw Clinically Equivalent to Titanium Screw in Hallux Valgus Surgery: Short Term Results of the First Prospective, Randomized, Controlled Clinical Pilot Study, Biomed. Eng. Online, 2013, 12, p 62–71.10.1186/1475-925X-12-62 ↗
4. R. Page, J. Beazley, S. Graves, S. Rainbird and Y. Peng, Effect of Glenosphere Size on Reverse Shoulder Arthroplasty Revision Rate: An Analysis from the Australian Orthopaedic Association National Joint Replacement Registry, J. Shoulder Elb. Surg., 2022 https://doi.org/10.1016/j.jse.2021.11.01310.1016/j.jse.2021.11.013 ↗
5. H. Mehboob and S.H. Chang, Application of Composites to Orthopedic Prostheses for Effective Bone Healing: A Review, Compos. Struct., 2014, 118, p 328–341.10.1016/j.compstruct.2014.07.052 ↗
6. S. Farah, D.G. Anderson and R. Langer, Physical and Mechanical Properties of PLA, and Their Functions in Widespread Applications—A Comprehensive Review, Adv. Drug Deliver. Rev., 2016, 107, p 367–392.10.1016/j.addr.2016.06.012 ↗
7. D.D. Silva, M. Kaduri, M. Poley, O. Adir, N. Krinsky, J.S. Roitman and A. Schroeder, Biocompatibility, Biodegradation and Excretion of Polylactic Acid (PLA) in Medical Implants and Theranostic Systems, Chem. Eng. J., 2018, 340, p 9–14.10.1016/j.cej.2018.01.010 ↗
8. P. Feng, J.Y. Jia, M.Y. Liu, S.P. Peng, Z.Y. Zhao and C.J. Shuai, Degradation Mechanisms and Acceleration Strategies of Poly (Lactic Acid) Scaffold for Bone Regeneration, Mater. Design, 2021, 210, 110066.10.1016/j.matdes.2021.110066 ↗
9. H. Tsuji, Hydrolytic Degradation, Poly(Lactic Acid): Synthesis, Structures, Properties, Processing, and Applications, Wiley Series on Polymer Engineering and Technology. R. Auras, L.T. Lim, S.E.M. Selke Ed., Wiley, Hoboken, 2010, p 345–381.
10. B. Laycock, M. Nikolic, J.M. Colwell, E. Gauthier, P. Halley, S. Bottle and G. George, Lifetime Prediction of Biodegradable Polymers, Prog. Polym. Sci., 2017, 71, p 144–189.10.1016/j.progpolymsci.2017.02.004 ↗
11. F.V. Burkersroda, L. Schedl and A. Gopferich, Why Degradable Polymers Undergo Surface Erosion or Bulk Erosion, Biomaterials, 2002, 23, p 4221–4231.10.1016/S0142-9612(02)00170-9 ↗
12. P.M. Varlet, S. Gogolewski and P. Nieuwenhuis, Long-Term Soft Tissue Reaction to Various Polylactides and Their in Vivo Degradation, J. Mater. Sci. Mater. Med., 1996, 7, p 713–721.10.1007/BF00121406 ↗
13. F.A. Barber and W.D. Dockery, Long-Term Absorption of Poly-l-Lactic Acid Interference Screws, Arthro. J. Arthro. Rel. Surg., 2006, 22, p 820–826.10.1016/j.arthro.2006.04.096 ↗
14. A.R. Amini, J.S. Wallace and S.P. Nukavarapu, Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants, J. Long Term Eff. Med. Implants, 2011, 21, p 93–122.10.1615/JLongTermEffMedImplants.v21.i2.10 ↗
15. E. Hasanpur, A. Ghazavizadeh, A. Sadeghi and M. Haboussi, In Vitro Corrosion Study of PLA/Mg Composites for Cardiovascular Stent Applications, J. Mech. Behav. Biomed., 2021, 124, 104768.10.1016/j.jmbbm.2021.104768 ↗
16. A. Ferrandez-Montero, M. Lieblich, R. Benavente, J.L. González-Carrasco and B. Ferrari, New Approach to Improve Polymer–Mg Interface in Biodegradable PLA/Mg Composites through Particle Surface Modification, Surf. Coat. Technol., 2020, 383, 125285.10.1016/j.surfcoat.2019.125285 ↗
17. X. Li, W.D. Yu, L.Y. Han, C.L. Chu, J. Bai and F. Xue, Degradation Behaviors of Mg Alloy Wires/PLA Composite in the Consistent and Staged Dynamic Environments, Mat. Sci. Eng. C, 2019, 103, 109765.10.1016/j.msec.2019.109765 ↗
18. H. Cai, J. Meng, X. Li, F. Xue, C.L. Chu, C. Guo and J. Bai, In Vitro Degradation Behavior of Mg Wire/Poly(Lactic Acid) Composite Rods Prepared by Hot Pressing and Hot Drawing, Acta Biomater., 2019, 98, p 125–141.10.1016/j.actbio.2019.05.059 ↗
19. C.L. Chu, X. Han, J. Bai, F. Xue and P.K. Chu, Fabrication and Degradation Behavior of Micro-Arc Oxidized Biomedical Magnesium Alloy Wires, Surf. Coat. Technol., 2012, 213, p 307–312.10.1016/j.surfcoat.2012.10.078 ↗
20. H. Cai, X. Li, F. Xue, C.L. Chu, C. Guo, J. Bai and X.B. Zhang, In Vitro Study on Cytocompatibility of Mg Wire/Poly(Lactic Acid) Composite Rods, J. Mater. Eng. Perform., 2021, 30, p 7214–7222.10.1007/s11665-021-05883-1 ↗
21. B. Gupta, N. Revagade, N. Anjum, B. Atthoff and J. Hilborn, Preparation of Poly(Lactic Acid) Fiber by Dry-Jet-Wet Spinning. I. Influence of Draw Ratio on Fiber Properties, J. Appl. Polym. Sci., 2006, 100, p 1239–1246.10.1002/app.23497 ↗
22. M. Entrialgo-Castano, A.E. Salvucci, A. Lendlein and D. Hofmann, An Atomistic Modeling and Quantum Mechanical Approach to the Hydrolytic Degradation of Aliphatic Polyesters, Macromol. Symp., 2008, 269, p 47–64.10.1002/masy.200850908 ↗
23. A. Gautieri, A. Mezzanzanica, A. Motta, A. Redealli and S. Vesentini, Atomistic Modeling of Water Diffusion in Hydrolytic Biomaterials, J. Mol. Model., 2012, 18, p 1495–1502.10.1007/s00894-011-1176-3 ↗
24. X.X. Tian and D.A. Bradley, Water Uptake, Distribution, and Mobility in Amorphous Poly(d, l-Lactide) by Molecular Dynamics Simulation, J. Pharm. Sci., 2014, 103, p 2759–2771.10.1002/jps.23855 ↗
25. H. Schmidt, Carbon Footprinting, Labeling and Life Cycle Assessment, Int. J. Life Cycle Ass., 2009, 14, p 6–9.10.1007/s11367-009-0071-y ↗
26. L.Y. Shi and L.S. Wang, Analysis on the Accounting Method of Reducing Carbon Emission of PLA Plastic Shopping Bags, Low Carbon World, 2021, 11, p 24–25.
27. X.T. Hou, C. Tian, Z.N. Han and X.R. Huang, Carbon Footprint Evaluation of Primary Magnesium Production Based on Autonomous Life Cycle Software, Liaoning Chem. Ind., 2020, 49, p 1522–1528.
28. S.A. Ashour, Effect of Compressive Strength and Tensile Reinforcement Ratio on Flexural Behavior of High-Strength Concrete Beams, Eng. Struct., 2000, 22, p 413–423.10.1016/S0141-0296(98)00135-7 ↗
29. J.C. Mccormac and R.H. Brown, Design of Reinforced Concrete, Wiley, Hoboken, 2014.
30. X. Li, C.L. Chu, L. Liu and J. Bai, Biodegradable Poly-Lactic Acid Based-Composite Reinforced Unidirectionally with High-Strength Magnesium Alloy Wires, Biomaterials, 2015, 49, p 135–144.10.1016/j.biomaterials.2015.01.060 ↗
31. F. Codari, S. Lazzari, M. Soos, G. Storti, M. Morbidelli and D. Moscatelli, Kinetics of the Hydrolytic Degradation of Poly(Lactic Acid), Polym. Degrad. Stabil., 2012, 97, p 2460–2466.10.1016/j.polymdegradstab.2012.06.026 ↗
32. D.F. Farrar and R.K. Gillson, Hydrolytic Degradation of Polyglyconate B: The Relationship Between Degradation Time, Strength and Molecular Weight, Biomaterials, 2002, 23, p 3905–3912.10.1016/S0142-9612(02)00140-0 ↗
33. M. Deng, J. Zhou, G. Chen, D. Burkley, Y. Xu, D. Jamiolkowski and T. Barbolt, Effect of Load and Temperature on In Vitro Degradation of Poly(Glycolide-Co-l-Lactide) Multifilament Braids, Biomaterials, 2005, 26, p 4327–4336.10.1016/j.biomaterials.2004.09.067 ↗
34. W.F. Ng, K.Y. Chiu and F.T. Cheng, Effect of pH on the in Vitro Corrosion Rate of Magnesium Degradable Implant Material, Mater. Sci. Eng. C, 2010, 30, p 898–903.10.1016/j.msec.2010.04.003 ↗
35. S.J.D. Jong, E.R. Arias, D.T.S. Rijkers, C.F.V. Nostrum, J.J.K.D. Bosch and W.E. Hennink, New Insights into the Hydrolytic Degradation of Poly(Lactic Acid): Participation of the Alcohol Terminus, Polymer, 2001, 42, p 2795–2802.10.1016/S0032-3861(00)00646-7 ↗
36. H. Tsuji, Poly(l-Lactide), Encyclopedia of Polymeric Nanomaterials. S. Kobayashi, K. Mullen Ed., Springer-Verlag, Berlin, 2015, p 1692–1702.10.1007/978-3-642-29648-2_398 ↗