journal article·2025-09

Novel Approach for Processing and Fabricating PLA/MgTiO3 Composite Filaments in Biomedical 3D Printing with Enhanced Mechanical and Thermal Properties

P. Vicky Kumar, Anil Kumar Birru, Nelson Muthu

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OpenAlex topics: Bone Tissue Engineering Materials · biodegradable polymer synthesis and properties · Additive Manufacturing and 3D Printing Technologies

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References (62)

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1. M. Mohammadi Zerankeshi, R. Bakhshi, and R. Alizadeh, Polymer/Metal Composite 3D Porous Bone Tissue Engineering Scaffolds Fabricated by Additive Manufacturing Techniques: A Review, Bioprinting, 2022, 25, e00191.10.1016/j.bprint.2022.e00191 ↗
2. P.B. Maurus and C.C. Kaeding, Bioabsorbable Implant Material Review, Operative Techn Sports Med, 2004, 12(3), p 158–160.10.1053/j.otsm.2004.07.015 ↗
3. P.U. Rokkanen, O. Böstman, and E. Hirvensalo, Bioabsorbable Fixation in Orthopaedic Surgery and Traumatology, Biomaterials, 2000, 21(24), p 2607–2613.10.1016/S0142-9612(00)00128-9 ↗
4. C. Shuai, Y. Li, and G. Wang, Surface Modification of Nanodiamond: Toward the Dispersion of Reinforced Phase in Poly-L-Lactic acid Scaffolds, Int. J. Biol. Macromol., 2019, 126, p 1116–1124.10.1016/j.ijbiomac.2019.01.004 ↗
5. J. Dong, C. Mei, and J. Han, 3D Printed Poly(Lactic Acid) Composites with Grafted Cellulose Nanofibers: Effect of Nanofiber and Post-Fabrication Annealing Treatment on Composite Flexural Properties, Addit. Manuf., 2019, 28, p 621–628.
6. H. Mei, Z. Ali, and Y. Yan, Influence of Mixed Isotropic Fiber Angles and Hot Press on the Mechanical Properties of 3D Printed Composites, Addit. Manuf., 2019, 27, p 150–158.
7. M. Mohammadi Zerankeshi, R. Bakhshi, and R. Alizadeh, Polymer/Metal Composite 3D Porous Bone Tissue Engineering Scaffolds Fabricated by Additive Manufacturing Techniques: A Review, Bioprinting, 2022, 25, e00191.10.1016/j.bprint.2022.e00191 ↗
8. M. Barbeck, T. Serra, and P. Booms, Analysis of the In Vitro Degradation and the In Vivo Tissue Response to Bi-Layered 3D-Printed Scaffolds Combining PLA and Biphasic PLA/Bioglass Components—Guidance of the Inflammatory Response as Basis for Osteochondral Regeneration, Bioact Mater, 2017, 2(4), p 208–223.
9. M.P. Bernardo, B.C.R. da Silva, and L.H.C. Mattoso, Development of Three-Dimensional Printing Filaments Based on Poly(Lactic Acid)/Hydroxyapatite Composites with Potential for Tissue Engineering, J. Compos. Mater., 2021, 55(17), p 2289–2300.10.1177/0021998320988568 ↗
10. J. Lee, H. Lee, and K.-H. Cheon, Fabrication of Poly(Lactic Acid)/Ti Composite Scaffolds with Enhanced Mechanical Properties and Biocompatibility via Fused Filament Fabrication (FFF)–Based 3D Printing, Addit. Manuf., 2019, 30, 100883.
11. C. Pascual-González, C. Thompson, and J. de la Vega, Processing and Properties of PLA/Mg Filaments for 3D Printing of Scaffolds for Biomedical Applications, Rapid Prototyp J, 2021, 28(5), p 884–894.10.1108/RPJ-06-2021-0152 ↗
12. M. Mohammadi Zerankeshi and R. Alizadeh, Ag-Incorporated Biodegradable Mg Alloys, Materialia, 2022, 23, 101445.10.1016/j.mtla.2022.101445 ↗
13. D. Jiang, F. Ning, and Y. Wang, Additive Manufacturing of Biodegradable Iron-Based Particle Reinforced Polylactic Acid Composite Scaffolds for Tissue Engineering, J. Mater. Process. Technol., 2021, 289, 116952.10.1016/j.jmatprotec.2020.116952 ↗
14. Y. Wang, M. Lei, and Q. Wei, 3D Printing Biocompatible l-Arg/GNPs/PLA Nanocomposites with Enhanced Mechanical Property and Thermal Stability, J. Mater. Sci., 2020, 55(12), p 5064–5078.10.1007/s10853-020-04353-8 ↗
15. Y. Chen, Z. Xu, and C. Smith, Recent Advances on the Development of Magnesium Alloys for Biodegradable Implants, Acta Biomater., 2014, 10(11), p 4561–4573.10.1016/j.actbio.2014.07.005 ↗
16. S. Agarwal, J. Curtin, and B. Duffy, Biodegradable Magnesium Alloys for Orthopaedic Applications: A Review on Corrosion, Biocompatibility and Surface Modifications, Mater. Sci. Eng. C, 2016, 68, p 948–963.10.1016/j.msec.2016.06.020 ↗
17. N. Erdmann, N. Angrisani, and J. Reifenrath, Biomechanical Testing and Degradation Analysis of MgCa0.8 Alloy Screws: A Comparative in Vivo Study in Rabbits, Acta Biomater., 2011, 7(3), p 1421–1428.10.1016/j.actbio.2010.10.031 ↗
18. D. Bellucci, A. Sola, and R. Salvatori, Role of Magnesium Oxide and Strontium Oxide as Modifiers in Silicate-Based Bioactive Glasses: Effects on Thermal Behaviour, Mechanical Properties and In-Vitro Bioactivity, Mater. Sci. Eng., C, 2017, 72, p 566–575.10.1016/j.msec.2016.11.110 ↗
19. K. Salma-Ancane, L. Stipniece, and A. Putnins, Development of Mg-Containing Porous β-Tricalcium Phosphate Scaffolds for Bone Repair, Ceram. Int., 2015, 41(3), p 4996–5004.10.1016/j.ceramint.2014.12.065 ↗
20. F. Witte, V. Kaese, and H. Haferkamp, In Vivo Corrosion of Four Magnesium Alloys and the Associated Bone Response, Biomaterials, 2005, 26(17), p 3557–3563.10.1016/j.biomaterials.2004.09.049 ↗
21. G. Eddy Jai Poinern, S. Brundavanam, and D. Fawcett, Biomedical Magnesium Alloys: A Review of Material Properties, Surface Modifications and Potential as a Biodegradable Orthopaedic Implant, Am. J. Biomed. Eng., 2013, 2(6), p 218–40.10.5923/j.ajbe.20120206.02 ↗
22. C. Liu, Z. Ren, and Y. Xu, Biodegradable Magnesium Alloys Developed as Bone Repair Materials: A Review, Scanning, 2018, 2018, p 1–15.
23. M. Niinomi, Mechanical Properties of Biomedical Titanium Alloys, Mater. Sci. Eng. A, 1998, 243(1–2), p 231–236.10.1016/S0921-5093(97)00806-X ↗
24. M. Niinomi, Recent Research and Development in Metallic Materials for Biomedical, Dental and Healthcare Products Applications, Mater. Sci. Forum, 2007, 539–543, p 193–200.10.4028/www.scientific.net/MSF.539-543.193 ↗
25. R. Van Noort, Titanium: The Implant Material of Today, J. Mater. Sci., 1987, 22(11), p 3801–3811.10.1007/BF01133326 ↗
26. B. Yang, M. Uchida, and H.-M. Kim, Preparation of Bioactive Titanium Metal via Anodic Oxidation Treatment, Biomaterials, 2004, 25(6), p 1003–1010.10.1016/S0142-9612(03)00626-4 ↗
27. H. Kim, Effect of Heat Treatment on Apatite-Forming Ability of Ti Metal Induced by Alkali Treatment, J. Mater. Sci. Mater. Med, 1997, 8, p 341–347.10.1023/A:1018524731409 ↗
28. B. Liang, S. Fujibayashi, and J. Tamura, Bone-Bonding Ability of Anodic Oxidized Titanium, Key Eng. Mater., 2003, 240–242, p 923–926.10.4028/www.scientific.net/KEM.240-242.923 ↗
29. H. Kaneko, M. Uchida, and H.M. Kim, Process of Apatite Formation Induced by Anatase on Titanium Metal in Simulated Body Fluid, Key Eng. Mater., 2001, 218–220, p 649–652.10.4028/www.scientific.net/KEM.218-220.649 ↗
30. M. Kulkarni, A. Mazare, P. Schmuki, and A. Iglic, Biomaterial Surface Modification of Titanium and Titanium Alloys for Medical Applications, Nanomedicine, 2014, 111(615), p 111.
31. M. Riaz, R. Zia, and A. Ijaz, Synthesis of Monophasic Ag Doped Hydroxyapatite and Evaluation of Antibacterial Activity, Mater. Sci. Eng. C, 2018, 90, p 308–313.10.1016/j.msec.2018.04.076 ↗
32. F. Alam, V.R. Shukla, and K.M. Varadarajan, Microarchitected 3D Printed Polylactic Acid (PLA) Nanocomposite Scaffolds for Biomedical Applications, J. Mech. Behav. Biomed. Mater., 2020, 103, 103576.10.1016/j.jmbbm.2019.103576 ↗
33. S.C. Daminabo, S. Goel, and S.A. Grammatikos, Fused Deposition Modeling-Based Additive Manufacturing (3D Printing): Techniques for Polymer Material Systems, Mater Today Chem, 2020, 16, 100248.
34. A. Valerga, M. Batista, and J. Salguero, Influence of PLA Filament Conditions on Characteristics of FDM Parts, Materials, 2018, 11(8), p 1322.10.3390/ma11081322 ↗
35. E.G. Ertane, A. Dorner-Reisel, and O. Baran, Processing and Wear Behaviour of 3D Printed PLA Reinforced with Biogenic Carbon, Advances in Tribology, 2018, 2018, p 1–11.10.1155/2018/1763182 ↗
36. I. Antoniac, D. Popescu, and A. Zapciu, Magnesium Filled Polylactic Acid (PLA) Material for Filament Based 3D Printing, Materials, 2019, 12(5), p 719.10.3390/ma12050719 ↗
37. R. Matsuzaki, M. Ueda, and M. Namiki, Three-Dimensional Printing of Continuous-Fiber Composites by in-Nozzle Impregnation, Sci. Rep., 2016, 6(1), p 23058.10.1038/srep23058 ↗
38. A. Maurel, M. Courty, and B. Fleutot, Highly Loaded Graphite-Polylactic Acid Composite-Based Filaments for Lithium-Ion Battery Three-Dimensional Printing, Chem. Mater., 2018, 30(21), p 7484–7493.10.1021/acs.chemmater.8b02062 ↗
39. J. Lee, H. Lee, K.-H. Cheon et al., Fabrication of Poly(Lactic Acid)/Ti Composite Scaffolds with Enhanced Mechanical Properties and Biocompatibility via Fused Filament Fabrication (FFF)–Based 3D Printing, Addit. Manuf., 2019, 30, 100883.
40. D. Jiang, F. Ning, and Y. Wang, Additive Manufacturing of Biodegradable Iron-Based Particle Reinforced Polylactic Acid Composite Scaffolds for Tissue Engineering, J. Mater. Process. Technol., 2021, 289, 116952.10.1016/j.jmatprotec.2020.116952 ↗
41. C. Pascual-González, J. De La Vega, and C. Thompson et al., Processing and Mechanical Properties of Novel Biodegradable Poly-Lactic Acid/Zn 3D Printed Scaffolds for Application in Tissue Regeneration, J. Mech. Behav. Biomed. Mater., 2022, 132, 105290.10.1016/j.jmbbm.2022.105290 ↗
42. I. Antoniac, D. Popescu, A. Zapciu et al., Magnesium Filled Polylactic Acid (PLA) Material for Filament Based 3D Printing, Materials, 2019, 12(5), p 719.10.3390/ma12050719 ↗
43. A. Ferrández-Montero, M. Lieblich, J.L. González-Carrasco et al., Development of Biocompatible and Fully Bioabsorbable PLA/Mg Films for Tissue Regeneration Applications, Acta Biomater., 2019, 98, p 114–124.10.1016/j.actbio.2019.05.026 ↗
44. Á. Díaz-García, J.Y. Law, A. Cota et al., Novel Procedure for Laboratory Scale Production of Composite Functional Filaments for Additive Manufacturing, Mater. Today Commun., 2020, 24, 101049.
45. S. Feliu, A. Pardo, M.C. Merino et al., Correlation between the Surface Chemistry and the Atmospheric Corrosion of AZ31, AZ80 and AZ91D Magnesium Alloys, Appl. Surf. Sci., 2009, 255(7), p 4102–4108.10.1016/j.apsusc.2008.10.095 ↗
46. T. Motoyama, T. Tsukegi, Y. Shirai et al., Effects of MgO Catalyst on Depolymerization of Poly-L-Lactic Acid to l, L-Lactide, Polym. Degrad. Stab., 2007, 92(7), p 1350–1358.10.1016/j.polymdegradstab.2007.03.014 ↗
47. S.C. Cifuentes, M. Lieblich, F.A. López et al., Effect of Mg Content on the Thermal Stability and Mechanical Behaviour of PLLA/Mg Composites Processed by Hot Extrusion, Mater. Sci. Eng. C, 2017, 72, p 18–25.10.1016/j.msec.2016.11.037 ↗
48. Z. Oksiuta, M. Jalbrzykowski, and J. Mystkowska, Mechanical and Thermal Properties of Polylactide (PLA) Composites Modified with Mg, Fe, and Polyethylene (PE) Additives, Polymers, 2020, 12(12), p 2939.10.3390/polym12122939 ↗
49. G. Chinga, P.O. Johnsen, R. Dougherty, E.L. Berli, and J. Walter, Quantification of the 3D Microstructure of SC Surfaces, J. Microsc., 2007, 227, p 254–265.10.1111/j.1365-2818.2007.01809.x ↗
50. S. Wu, S. Zellnitz, A. Mercuri, S. Salar-Behzadi, M. Bresciani, and E. Fröhlich, An In Vitro and In Silico Study of the Impact of Engineered Surface Modifications on Drug Detachment From Model Carriers, Int. J. Pharm., 2016, 513, p 109–117.10.1016/j.ijpharm.2016.08.064 ↗
51. D01 Committee, Practice for Surface Wettability of Coatings, Substrates and Pigments by Advancing Contact Angle Measurement. ASTM International. https://doi.org/10.1520/d7334-08r22.10.1520/d7334-08r22 ↗
52. L. Zhang, S. Feih, and S. Daynes, Energy Absorption Characteristics of Metallic Triply Periodic Minimal Surface Sheet Structures under Compressive Loading, Addit. Manuf., 2018, 23, p 505–515.
53. X.-F. Wei, R.-Y. Bao, Z.-Q. Cao et al., Stereocomplex Crystallite Network in Asymmetric PLLA/PDLA Blends: Formation, Structure, and Confining Effect on the Crystallization Rate of Homocrystallites, Macromolecules, 2014, 47(4), p 1439–1448.10.1021/ma402653a ↗
54. P. Krishnamachari, J. Zhang, and J. Lou, Biodegradable Poly(Lactic Acid)/Clay Nanocomposites by Melt Intercalation: A Study of Morphological, Thermal, and Mechanical Properties, Int. J. Polym. Analy. Charact., 2009, 14(4), p 336–350.10.1080/10236660902871843 ↗
55. I. Antoniac, D. Popescu, A. Zapciu et al., Magnesium Filled Polylactic Acid (PLA) Material for Filament Based 3D Printing, Materials, 2019, 12(5), p 719.10.3390/ma12050719 ↗
56. M. Mohammadi Zerankeshi, S. Mofakhami, and E. Salahinejad, 3D Porous HA/TCP Composite Scaffolds for Bone Tissue Engineering, Ceram. Int., 2022, 48(16), p 22647–22663. https://doi.org/10.1016/j.ceramint.2022.05.10310.1016/j.ceramint.2022.05.103 ↗
57. E.Q. Dong, M. Zhang, X. Zhou, Y. Shao, J. Li, L. Wang, C. Chu, F. Xue, Q. Yao, and J. Bai, 3D-Printed Mg-Incorporated PCL-Based Scaffolds: A Promising Approach for Bone Healing, Mater. Sci. Eng. C., 2021, 129, p 112372.10.1016/j.msec.2021.112372 ↗
58. S. Calamak and M. Ermis, In Situ Silver Nanoparticle Synthesis on 3D-Printed Polylactic Acid Scaffolds for Biomedical Applications, J. Mater. Res., 2021, 36, p 166–175.10.1557/s43578-020-00064-7 ↗
59. V. Karageorgiou and D. Kaplan, Porosity of 3D Biomaterial Scaffolds and Osteogenesis, Biomaterials, 2005, 26(27), p 5474–91.10.1016/j.biomaterials.2005.02.002 ↗
60. D.L. Kopperdahl and T.M. Keaveny, Yield Strain Behavior of Trabecular Bone, J. Biomech., 1998, 31(7), p 601–608.10.1016/S0021-9290(98)00057-8 ↗
61. J. Lee, H. Lee, K.-H. Cheon et al., Fabrication of Poly(lactic acid)/Ti Composite Scaffolds with Enhanced Mechanical Properties and Biocompatibility via Fused Filament Fabrication (FFF)–Based 3D Printing, Addit. Manuf., 2019, 30, 100883.
62. F. Alam, V.R. Shukla, K.M. Varadarajan et al., Microarchitected 3D Printed Polylactic Acid (PLA) Nanocomposite Scaffolds for Biomedical Applications, J. Mech. Behav. Biomed. Mater., 2020, 103, 103576.10.1016/j.jmbbm.2019.103576 ↗