Production and Characterization of a Bone-Like Porous Ti/Ti-Hydroxyapatite Functionally Graded Material
Source abstract
Abstract
A new kind of functionally graded material (FGM) that mimics the inner porous structure and outer dense layer of human bone was produced using powder metallurgy. The inner part of the FGM material (16 mm in diameter) has porosity of approximately 60%, and its mechanical properties are compatible with cortical bone; however, the shell (1.8 mm in thickness) is composed of a layer of Ti-10% wt. hydroxyapatite (HA) and shows hydrophilic behavior and improved biofunction. Elastic moduli of the core and shell layer were calculated as 18.99 and 42.98 GPa, respectively, and those values are compatible with that of cortical bone. Addition of HA to the shell had a significant effect on the wettability (81.6% decrease) and cell viability (46% increase). Furthermore, the porosity of the shell layer (28.88%) is similar to that of human cortical bone. It is concluded that the developed Ti-HA FGM has promising properties for implant applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (51)
Show source-provided references
1. B. Zhang, D. Myers, G. Wallace, M. Brandt, and P. Choong, Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings, Int. J. Mol. Sci., 2014, 15(7), p 11878–11921. https://doi.org/10.3390/ijms15071187810.3390/ijms150711878 ↗
2. M. Geetha, A.K. Singh, R. Asokamani, and A.K. Gogia, Ti Based Biomaterials, the Ultimate Choice for Orthopaedic Implants—A Review, Prog. Mater Sci., 2009, 54(3), p 397–425. https://doi.org/10.1016/j.pmatsci.2008.06.00410.1016/j.pmatsci.2008.06.004 ↗
3. E. Yilmaz, A. Gökçe, F. Findik, and H.Ö. Gülsoy, Powder Metallurgy Processing of Ti-Nb Based Biomedical Alloys, Acta Phys. Pol., A, 2018, 134(1), p 278–280. https://doi.org/10.12693/APhysPolA.134.27810.12693/APhysPolA.134.278 ↗
4. E. Yılmaz, A. Gökçe, F. Findik, and H.Ö. Gülsoy, Characterization of Biomedical Ti-16Nb-(0–4)Sn Alloys Produced by Powder Injection Molding, Vacuum, 2017, 142, p 164–174. https://doi.org/10.1016/j.vacuum.2017.05.01810.1016/j.vacuum.2017.05.018 ↗
5. E. Yılmaz, B. Çakıroğlu, A. Gökçe, F. Findik, H.O. Gulsoy, N. Gulsoy, Ö. Mutlu, and M. Özacar, Novel Hydroxyapatite/Graphene Oxide/Collagen Bioactive Composite Coating on Ti16Nb Alloys by Electrodeposition, Mater. Sci. Eng., C, 2019, 101, p 292–305. https://doi.org/10.1016/j.msec.2019.03.07810.1016/j.msec.2019.03.078 ↗
6. E. Yılmaz, A. Gökçe, F. Findik, and H.Ö. Gulsoy, Metallurgical Properties and Biomimetic HA Deposition Performance of Ti-Nb PIM Alloys, J. Alloys Compd., 2018, 746, p 301–313. https://doi.org/10.1016/j.jallcom.2018.02.27410.1016/j.jallcom.2018.02.274 ↗
7. S. Sazesh, A. Ghassemi, R. Ebrahimi, and M. Khodaei, Fabrication and Characterization of NHA/Titanium Dental Implant, Mater. Res. Express, 2019, 6(4), p 045060. https://doi.org/10.1088/2053-1591/aafddc10.1088/2053-1591/aafddc ↗
8. S. Anil, P.S. Anand, H. Alghamdi, and J.A. Janse, Dental Implant Surface Enhancement and Osseointegration, Implant Dentistry - A Rapidly Evolving Practice, I. Turkyilmaz, Ed., (Rijeka), InTech, 2011, https://doi.org/10.5772/16475.10.5772/16475 ↗
9. A. Arifin, A.B. Sulong, N. Muhamad, J. Syarif, and M.I. Ramli, Material Processing of Hydroxyapatite and Titanium Alloy (HA/Ti) Composite as Implant Materials Using Powder Metallurgy: A Review, Mater. Des., 2014, 55, p 165–175. https://doi.org/10.1016/j.matdes.2013.09.04510.1016/j.matdes.2013.09.045 ↗
10. A. Jarrahi, H.A. Shirazi, A. Asnafi, and M.R. Ayatollahi, Biomechanical Analysis of a Radial Functionally Graded Dental Implant-Bone System under Multi-Directional Dynamic Loads, J. Brazilian Soc. Mech. Sci. Eng., 2018, 40(5), p 249. https://doi.org/10.1007/s40430-018-1166-910.1007/s40430-018-1166-9 ↗
11. M. Mehrali, F.S. Shirazi, M. Mehrali, H.S.C. Metselaar, N.A. Bin Kadri, and N.A.A. Osman, Dental Implants from Functionally Graded Materials, J. Biomed. Mater. Res., Part A, 2013, 101(10), p 3046–3057. https://doi.org/10.1002/jbm.a.3458810.1002/jbm.a.34588 ↗
12. M. Sedighi, N. Omidi, and A. Jabbari, Experimental Investigation of FGM Dental Implant Properties Made from Ti/HA Composite, Mech. Adv. Compos. Struct., 2017, 4(3), p 233–237. https://doi.org/10.22075/macs.2017.1819.109610.22075/macs.2017.1819.1096 ↗
13. M. Roy, V.K. Balla, A. Bandyopadhyay, and S. Bose, Compositionally Graded Hydroxyapatite/Tricalcium Phosphate Coating on Ti by Laser and Induction Plasma, Acta Biomater., 2011, 7(2), p 866–873. https://doi.org/10.1016/j.actbio.2010.09.01610.1016/j.actbio.2010.09.016 ↗
14. H.-D. Jung, H. Lee, H.-E. Kim, Y.-H. Koh, and J. Song, Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications, J. Vis. Exp., 2015, https://doi.org/10.3791/5327910.3791/53279 ↗
15. H. Lee, T.-S. Jang, J. Song, H.-E. Kim, and H.-D. Jung, The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting, Materials, 2017, 10(4), p 367. https://doi.org/10.3390/ma1004036710.3390/ma10040367 ↗
16. Y.H. He, Y.Q. Zhang, Y.H. Jiang, and R. Zhou, Effect of HA (Hydroxyapatite) Content on the Microstructure, Mechanical and Corrosion Properties of (Ti13Nb13Zr)-XHA Biocomposites Synthesized by Sparkle Plasma Sintering, Vacuum, 2016, 131, p 176–180. https://doi.org/10.1016/j.vacuum.2016.06.01510.1016/j.vacuum.2016.06.015 ↗
17. C. Han, Y. Li, Q. Wang, D. Cai, Q. Wei, L. Yang, S. Wen, J. Liu, and Y. Shi, Titanium/Hydroxyapatite (Ti/HA) Gradient Materials with Quasi-Continuous Ratios Fabricated by SLM: Material Interface and Fracture Toughness, Mater. Des., 2018, 141, p 256–266. https://doi.org/10.1016/j.matdes.2017.12.03710.1016/j.matdes.2017.12.037 ↗
18. E. Yılmaz, A. Gökçe, F. Findik, H.O. Gulsoy, and O. İyibilgin, Mechanical Properties and Electrochemical Behavior of Porous Ti-Nb Biomaterials, J. Mech. Behav. Biomed. Mater., 2018, 87, p 59–67. https://doi.org/10.1016/j.jmbbm.2018.07.01810.1016/j.jmbbm.2018.07.018 ↗
19. E. Yılmaz, A. Gökçe, F. Findik, and H.Ö. Gülsoy, Biomedical Porous Ti-16Nb-10Zr-(0–15)Ta Alloys, Int. J. Mater. Res., 2019, 110(4), p 375–378. https://doi.org/10.3139/146.11174910.3139/146.111749 ↗
20. P. Balbinotti, E. Gemelli, G. Buerger, S.A. de Lima, J. de Jesus, N.H.A. Camargo, V.A.R. Henriques, and G.D.A. de Soares, Microstructure Development on Sintered Ti/HA Biocomposites Produced by Powder Metallurgy, Mater. Res., 2011, 14(3), p 384–393. https://doi.org/10.1590/s1516-1439201100500004410.1590/s1516-14392011005000044 ↗
21. T. Kokubo and S. Yamaguchi, Novel Bioactive Materials Developed by Simulated Body Fluid Evaluation: Surface-Modified Ti Metal and Its Alloys, Acta Biomater., 2016, 44, p 16–30. https://doi.org/10.1016/j.actbio.2016.08.01310.1016/j.actbio.2016.08.013 ↗
22. N. Omidi, A.H. Jabbari, and M. Sedighi, Mechanical and Microstructural Properties of Titanium/Hydroxyapatite Functionally Graded Material Fabricated by Spark Plasma Sintering, Powder Metall., 2018, 61(5), p 417–427. https://doi.org/10.1080/00325899.2018.153539110.1080/00325899.2018.1535391 ↗
23. M. Kutz, Bone Mechanics, Standard Handbook of Biomedical Engineering and Design, McGraw-Hill Professional, 2003
24. B. Dabrowski, W. Swieszkowski, D. Godlinski, and K.J. Kurzydlowski, Highly Porous Titanium Scaffolds for Orthopaedic Applications, J. Biomed. Mater. Res. Part B Appl. Biomater., 2010, 95(1), p 53–6110.1002/jbm.b.31682 ↗
25. S.P. Victor, M.G. Gayathri Devi, W. Paul, V.M. Vijayan, J. Muthu, and C.P. Sharma, Europium Doped Calcium Deficient Hydroxyapatite as Theranostic Nanoplatforms: Effect of Structure and Aspect Ratio, ACS Biomater. Sci. Eng., 2017, 3(12), p 3588–3595. https://doi.org/10.1021/acsbiomaterials.7b0045310.1021/acsbiomaterials.7b00453 ↗
26. L. Zhang, Z.Y. He, Y.Q. Zhang, Y.H. Jiang, and R. Zhou, Rapidly Sintering of Interconnected Porous Ti-HA Biocomposite with High Strength and Enhanced Bioactivity, Mater. Sci. Eng., C, 2016, 67, p 104–114. https://doi.org/10.1016/j.msec.2016.05.00110.1016/j.msec.2016.05.001 ↗
27. H. Ye, X.Y. Liu, and H. Hong, Characterization of Sintered Titanium/Hydroxyapatite Biocomposite Using FTIR Spectroscopy, J. Mater. Sci. Mater. Med., 2009, 20(4), p 843–850. https://doi.org/10.1007/s10856-008-3647-310.1007/s10856-008-3647-3 ↗
28. G. Alexandru Mihai, Ed., “Nanobiomaterials in Hard Tissue Engineering. Elsevier, 2016, https://doi.org/10.1016/c2015-0-00379-3.10.1016/c2015-0-00379-3 ↗
29. D. Smolen, T. Chudoba, I. Malka, A. Kedzierska, W. Lojkowski, W. Swieszkowski, K.J. Kurzydlowski, M. Kolodziejczyk-Mierzynska, and M. Lewandowska-Szumiel, Highly Biocompatible, Nanocrystalline Hydroxyapatite Synthesized in a Solvothermal Process Driven by High Energy Density Microwave Radiation, Int. J. Nanomed., 2013, https://doi.org/10.2147/ijn.s3929910.2147/ijn.s39299 ↗
30. Y. Yang, K.-H. Kim, C.M. Agrawal, and J.L. Ong, Interaction of Hydroxyapatite-Titanium at Elevated Temperature in Vacuum Environment, Biomaterials, 2004, 25(15), p 2927–2932. https://doi.org/10.1016/j.biomaterials.2003.09.07210.1016/j.biomaterials.2003.09.072 ↗
31. G. Kahraman, Production and Characterization of Titanium - Hydroxyapatite Composites by Powder Metallurgy Method, Sakarya University of Applied Sciences, 2019, https://doi.org/https://tez.yok.gov.tr/UlusalTezMerkezi/TezGoster?key=npGs9H39x7G6401x51yqpADG0EGr6w0hqX5lDog8h19sXJGb7Ymx1rmbhYctHgwy.
32. G. Kahraman, E. Yılmaz, and F. Fındık, Characterization of Ti-HA Biocomposite Produced by Powder Metallurgy, in 4th International conference on Materials Science and Technology, (Ankara), 2019, p 532–535.
33. Y. Shu, G. Ou, L. Wang, J. Zou, and Q. Li, Surface Modification of Titanium with Heparin-Chitosan Multilayers via Layer-by-Layer Self-Assembly Technique, J. Nanomater., 2011, 2011, p 1–8. https://doi.org/10.1155/2011/42368610.1155/2011/423686 ↗
34. A. Kumar, K. Biswas, and B. Basu, On the Toughness Enhancement in Hydroxyapatite-Based Composites, Acta Mater., 2013, 61(14), p 5198–5215. https://doi.org/10.1016/j.actamat.2013.05.01310.1016/j.actamat.2013.05.013 ↗
35. A.T. Sidambe, Biocompatibility of Advanced Manufactured Titanium Implants-A Review, Materials, 2014, 7(12), p 8168–8188. https://doi.org/10.3390/ma712816810.3390/ma7128168 ↗
36. E. Yılmaz, A. Gökçe, F. Findik, and H.Ö. Gulsoy, Assessment of Ti–16Nb–XZr Alloys Produced via PIM for Implant Applications, J. Thermal Anal. Calorim., 2017, 134, p 1–8. https://doi.org/10.1007/s10973-017-6808-010.1007/s10973-017-6808-0 ↗
37. L. Zhang, Z.Y. He, Y.Q. Zhang, Y.H. Jiang, and R. Zhou, Enhanced in Vitro Bioactivity of Porous NiTi–HA Composites with Interconnected Pore Characteristics Prepared by Spark Plasma Sintering, Mater. Des., 2016, 101, p 170–180. https://doi.org/10.1016/j.matdes.2016.03.12810.1016/j.matdes.2016.03.128 ↗
38. Y.L. Gao, Y. Liu, and X.Y. Song, Plasma-Sprayed Hydroxyapatite Coating for Improved Corrosion Resistance and Bioactivity of Magnesium Alloy, J. Therm. Spray Technol., 2018, 27(8), p 1381–1387. https://doi.org/10.1007/s11666-018-0760-910.1007/s11666-018-0760-9 ↗
39. U. Anjaneyulu, B. Priyadarshini, S. Arul Xavier Stango, M. Chellappa, M. Geetha, and U. Vijayalakshmi, Preparation and Characterisation of Sol–Gel-Derived Hydroxyapatite Nanoparticles and Its Coatings on Medical Grade Ti-6Al-4V Alloy for Biomedical Applications, Mater. Technol., 2017, 32(13), p 800–814. https://doi.org/10.1080/10667857.2017.136447610.1080/10667857.2017.1364476 ↗
40. C.M. Cotrut, A. Vladescu, M. Dinu, and D.M. Vranceanu, Influence of Deposition Temperature on the Properties of Hydroxyapatite Obtained by Electrochemical Assisted Deposition, Ceram. Int., 2018, 44(1), p 669–677. https://doi.org/10.1016/j.ceramint.2017.09.22710.1016/j.ceramint.2017.09.227 ↗
41. C.J. Wilson, R.E. Clegg, D.I. Leavesley, and M.J. Pearcy, Mediation of Biomaterial-Cell Interactions by Adsorbed Proteins: A Review, Tissue Eng., 2005, 11(1-2), p 1–18. https://doi.org/10.1089/ten.2005.11.110.1089/ten.2005.11.1 ↗
42. J.K. Odusote, Y. Danyuo, A.D. Baruwa, and A.A. Azeez, Synthesis and Characterization of Hydroxyapatite from Bovine Bone for Production of Dental Implants, J. Appl. Biomater. Funct. Mater., 2019, 17(2), p 228080001983682. https://doi.org/10.1177/228080001983682910.1177/2280800019836829 ↗
43. Anawati, H. Tanigawa, H. Asoh, T. Ohno, M. Kubota, and S. Ono, Electrochemical Corrosion and Bioactivity of Titanium-Hydroxyapatite Composites Prepared by Spark Plasma Sintering, Corros. Sci., 2013, 70, p 212–220. https://doi.org/10.1016/j.corsci.2013.01.03210.1016/j.corsci.2013.01.032 ↗
44. B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter, Molecular Biology of the Cell, (New York), Garland Science, 2002, https://www.ncbi.nlm.nih.gov/books/NBK21054/.
45. C. Jeon, K.C. Oh, K.-H. Park, and H.S. Moon, Effects of Ultraviolet Treatment and Alendronate Immersion on Osteoblast-like Cells and Human Gingival Fibroblasts Cultured on Titanium Surfaces, Sci. Rep., 2019, 9(1), p 2581. https://doi.org/10.1038/s41598-019-39355-310.1038/s41598-019-39355-3 ↗
46. J. Suwanprateeb, W. Suvannapruk, W. Chokevivat, S. Kiertkrittikhoon, N. Jaruwangsanti, and P. Tienboon, Bioactivity of a Sol–Gel-Derived Hydroxyapatite Coating on Titanium Implants in Vitro and in Vivo, Asian Biomed., 2018, 12(1), p 35–44. https://doi.org/10.1515/abm-2018-002910.1515/abm-2018-0029 ↗
47. A. Rutkovskiy, K.-O. Stensløkken, and I.J. Vaage, Osteoblast Differentiation at a Glance, Med. Sci. Monit. Basic Res., 2016, 22, p 95–106. https://doi.org/10.12659/MSMBR.90114210.12659/MSMBR.901142 ↗
48. S. Dey, M. Das, and V.K. Balla, Effect of Hydroxyapatite Particle Size, Morphology and Crystallinity on Proliferation of Colon Cancer HCT116 Cells, Mater. Sci. Eng., C, 2014, 39, p 336–339. https://doi.org/10.1016/j.msec.2014.03.02210.1016/j.msec.2014.03.022 ↗
49. Y. Parcharoen, P. Termsuksawad, and S. Sirivisoot, Improved Bonding Strength of Hydroxyapatite on Titanium Dioxide Nanotube Arrays Following Alkaline Pretreatment for Orthopedic Implants, J. Nanomater., 2016, 2016, p 1–13. https://doi.org/10.1155/2016/914396910.1155/2016/9143969 ↗
50. G.M. Peñarrieta-Juanito, M. Costa, M. Cruz, G. Miranda, B. Henriques, J. Marques, R. Magini, A. Mata, J. Caramês, F. Silva, and J.C.M. Souza, Bioactivity of Novel Functionally Structured Titanium-Ceramic Composites in Contact with Human Osteoblasts, J. Biomed. Mater. Res., Part A, 2018, 106(7), p 1923–1931. https://doi.org/10.1002/jbm.a.3639410.1002/jbm.a.36394 ↗
51. Y. Zeng, X. Pei, S. Yang, H. Qin, H. Cai, S. Hu, L. Sui, Q. Wan, and J. Wang, Graphene Oxide/Hydroxyapatite Composite Coatings Fabricated by Electrochemical Deposition, Surf. Coatings Technol., 2016, 286, p 72–79. https://doi.org/10.1016/j.surfcoat.2015.12.01310.1016/j.surfcoat.2015.12.013 ↗