Oral nanotherapeutics with enhanced mucus penetration and ROS-responsive drug release capacities for delivery of curcumin to colitis tissues
Source abstract
Abstract
-rich environment. Additionally, P-CUR/CAT-NPs showed the strongest capacity to suppress the secretion of the main pro-inflammatory cytokines, in comparison with their counterparts (CUR-NPs and P-CUR-NPs). Importantly, oral administration of P-CAT/CUR-NPs showed the best therapeutic outcomes than the other NPs. Collectively, these results clearly demonstrate that these mucus-penetrating NPs loaded with CAT and CUR can be exploited as an efficient nanotherapeutic for UC therapy.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Curcumin's Biomedical Applications · Advancements in Transdermal Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Silkworm Genome Biology
College of Sericulture
Textile and Biomass Sciences
Southwest University
Chongqing 400715
Department of Chemistry
Georgia State University
Atlanta
USA
Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing
School of Materials and Energy
P. R. China
Funding
National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Venture and Innovation Support Program for Chongqing Overseas Returnees
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