journal article·2021

Riboflavin-based carbon dots with high singlet oxygen generation for photodynamic therapy

Juan Yue, Li Li, Chenyu Jiang, Qian Mei, Wen-Fei Dong, Ruhong Yan

Journal of Materials Chemistry B· Volume 9· Issue 38
Publisher page

Abstract

Photodynamic therapy, as an effective treatment for superficial tumors, has attracted more and more attention. The development of safe, biocompatible and in vivo photosensitive materials is helpful to promote photodynamic therapy. Here we report green fluorescent carbon quantum dots prepared from a natural vitamin, riboflavin (VB2), as a photosensitizer. The VB2-based carbon dots have excellent water solubility and biocompatibility, and their singlet oxygen generation ability is much stronger than that of riboflavin itself. Through endocytosis, the carbon dots can easily enter the cells and show bright green fluorescence. In vivo experiments show that after photodynamic therapy the carbon dots can significantly inhibit the growth of tumors, and will not have toxic and side effects on other organs.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, P. R. China

The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou 215153, P. R. China

CAS Key Laboratory of Biomedical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science (CAS), 88 Keling Road, Suzhou 215163, P. R. China

Jinan Guokeyigong Science and Technology Development Co., Ltd, Jinan 250103, P. R. China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Jiangsu Provincial Key Research and Development Program · Chinese Academy of Sciences · Youth Innovation Promotion Association of the Chinese Academy of Sciences

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