journal article·2020

Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives

Jie Liao, Bo Xu, Ruihong Zhang, Yubo Fan, Huiqi Xie, Xiaoming Li

Journal of Materials Chemistry B· Volume 8· Issue 44
Publisher page

Abstract

Decellularized materials (DMs) are attracting more and more attention because of their native structures, comparatively high bioactivity, low immunogenicity and good biodegradability, which are difficult to be imitated by synthetic materials. Recently, DMs have been demonstrated to possess great potential to overcome the disadvantages of autografts and have become a kind of promising material for tissue engineering. In this systematic review, we aimed to not only provide a quick access for understanding DMs, but also bring new ideas to utilize them more appropriately in tissue engineering. Firstly, the preparation of DMs was introduced. Then, the updated applications of DMs derived from different tissues and organs in tissue engineering were comprehensively summarized. In particular, their advantages, drawbacks and current improvements were emphasized. Moreover, we analyzed and proposed future perspectives.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Tissue Engineering and Regenerative Medicine · Electrospun Nanofibers in Biomedical Applications · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education

School of Biological Science and Medical Engineering

Beijing Advanced Innovation Center for Biomedical Engineering

Beihang University

Beijing 100083

Department of Research and Teaching

the Fourth Central Hospital of Baoding City

Baoding 072350

China

Laboratory of Stem Cell and Tissue Engineering

State Key Laboratory of Biotherapy and Cancer Center

West China Hospital

Sichuan University and Collaborative Innovation Center of Biotherapy

Chengdu 610041

Funding

National Basic Research Program of China · Ministry of Education of the People’s Republic of China · Ministry of Science and Technology of the People’s Republic of China · Higher Education Discipline Innovation Project · West China Hospital, Sichuan University

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