Magnetophoresis-Based particle separation in microfluidic channels using grooved current-carrying conductor: Design, simulation, and optimization
Source abstract
Abstract
This study investigates the application of magnetophoresis for efficient particle separation within microfluidic channels. By modifying the structure of a current-carrying conductor, a controlled magnetic field gradient is generated. This gradient exerts precise forces on magnetic particles, influencing their trajectories in the laminar flow of the microchannel. The system design incorporates an asymmetric groove in the conductor to enhance the non-uniformity of the magnetic field, thereby optimizing particle manipulation. Finite element simulations are conducted to analyze and validate the performance of the system under varying parameters such as groove dimensions, electric current intensity, and fluid flow rates. Results demonstrate that optimal design parameters significantly improve separation efficiency, highlighting the potential of magnetophoresis for biomedical and industrial applications requiring precise particle handling in microfluidic environments.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Microfluidic and Bio-sensing Technologies · Electrostatics and Colloid Interactions · Microfluidic and Capillary Electrophoresis Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (29)
Show source-provided references
1. Connections between single-cell biomechanics and human disease states: Gastrointestinal cancer and malaria10.1016/j.actbio.2004.09.001 ↗
2. Cell and biomolecular mechanics in silico10.1038/nmat2040 ↗
3. Simultaneous diamagnetic and magnetic particle trapping in ferrofluid microflows via a single permanent magnet10.1063/1.4926615 ↗
4. Biocompatible and label-free separation of cancer cells from cell culture lines from white blood cells in ferrofluids10.1039/C7LC00327G ↗
5. Magnetic particle separation using current-carrying plates: A novel geometry in magnetophoresis10.1016/j.sna.2023.114897 ↗
6. Spreading of a ferrofluid core in three-stream micromixer channels10.1063/1.4919927 ↗
7. Separation of particles with bacterial size range using the control of sheath flow ratio in spiral microfluidic channel10.1016/j.sna.2018.12.047 ↗
8. Recent advances in microparticle continuous separation10.1049/iet-nbt:20070025 ↗
9. A novel magnetic microfluidic platform for on-chip separation of 3 types of silica coated magnetic nanoparticles (Fe3O4 @ SiO2)10.1016/j.sna.2017.12.047 ↗
10. A novel dielectrophoresis activated cell sorter (DACS) to evaluate the apoptotic rate of K562 cells treated with arsenic trioxide (As2O3)10.1016/j.sna.2016.02.034 ↗
11. Thermophoresis: Moving particles with thermal gradients10.1039/b805888c ↗
12. The advancement of blood cell research by optical tweezers10.1016/j.revip.2020.100043 ↗
13. Particle separation by standing surface acoustic waves inside a sessile droplet10.1016/j.sna.2021.112731 ↗
14. Magnetism and microfluidics10.1039/B513005K ↗
15. A review on magnetophoretic immunoseparation10.1166/jnn.2016.10930 ↗
16. Recent advances and current challenges in magnetophoresis based micro magnetofluidics10.1063/1.5035388 ↗
17. Microfluidic magnetic separator using an array of soft magnetic elements10.1063/1.2159418 ↗
18. Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis10.1039/b604542a ↗
19. Single-cell isolation of circulating tumor cells from whole blood by lateral magnetophoretic microseparation and microfluidic dispensing10.1021/acs.analchem.6b00570 ↗
20. Combination of dynamic magnetophoretic separation and stationary magnetic trap for highly sensitive and selective detection of Salmonella typhimurium in complex matrix10.1016/j.bios.2015.07.019 ↗
21. Simultaneous separation of different magnetic particles by sputtering magnetic wires at the bottom of a microchip: Novel geometry in magnetophoresis10.1016/j.jmmm.2023.170816 ↗
22. Microdevice for continuous flow magnetic separation for bioengineering applications10.1088/1361-6439/aa666d ↗
23. Eshaghi M. Nazari M. Particle separation in a microchannel by applying magnetic fields and nickel sputtering 2020 HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/PII/S0304885320309616.10.1016/j.jmmm.2020.167121 ↗
24. Microfluidic multi-target sorting by magnetic repulsion10.1007/s10404-018-2083-z ↗
25. Separation and trapping of magnetic particles by insertion of ferromagnetic wires inside a microchip: Proposing a novel geometry in magnetophoresis10.1016/j.jmmm.2022.169424 ↗
26. Three-dimensional analysis and enhancement of continuous magnetic separation of particles in microfluidics10.1007/s10404-014-1516-6 ↗
27. Purcell E.M. Morin D.J. Electricity and magnetism: third edition 2020 Cambridge University Press www.cambridge.org.
28. Microfluidics based magnetophoresis: A review10.1002/tcr.201800018 ↗
29. Design and development of a traveling wave ferro-microfluidic device and system rig for potential magnetophoretic cell separation and sorting in a water-based ferrofluid10.3390/mi14040889 ↗