Effect of plaque geometry on targeted delivery of stem cells containing magnetic particles in a rigid and elastic curved artery with stenosis
Source abstract
Abstract
Abstract Magnetic drug targeting (MDT) is a new and effective therapeutic technique to treat some diseases. In this method, the transfer of magnetic particles labeled with therapeutic agents in the presence of a magnetic field increases the efficiency of treatment. In this study, targeted delivery of endothelial cells containing magnetic particles in a stenosed curved artery for solid and elastic wall states was investigated, using an external magnetic field. The Eulerian-Lagrangian approach and the Eulerian-Lagrangian coupled FSI technique were employed to solve the continuum equations and track the trajectory of cells in a rigid and elastic artery, respectively. The influence of parameters was investigated, such as the mass of magnetic particles injected in each cell, the magnetic field strength, the injection time, the occlusion percentage, and the chord length of stenosis on the capture efficiency (CE). The effect of wall elasticity on CE was also studied. The results reveal that by increasing the mass of magnetic particles injected in each cell from 20 pg to 300 pg, the cells absorption at the target site is enhanced from 17% to 43%. Also, a slight increase in the magnetic field strength has a significant effect on increasing the CE. The injection of cells in a complete period of the cardiac cycle provides greater CE than other systole and diastole intervals. Examining the stenosis morphology shows that reducing the occlusion percentage from 40% to 20% and the chord length of stenosis from 70° to 30° results in an increase in the CE about 6% and 3% for 300 pg of magnetic particles in each cell, respectively. The trend of CE changes is the same for elastic artery and the rigid artery. However, in all cases, the elastic artery has a higher CE than the rigid artery. The obtained results can be useful for the treatment of atherosclerosis in curved vessels using targeted cell delivery.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Characterization and Applications of Magnetic Nanoparticles · Electrospun Nanofibers in Biomedical Applications · Lattice Boltzmann Simulation Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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