Magnetically modulated optical nanoprobes (MagMOONs) for detection and measurement of biologically important ions against the natural background fluorescence of intracellular environments

Magnetically modulated optical nanoprobes (MagMOONs) have been synthesized for the detection of pH changes in intracellular environments. MagMOONs are nanosensors designed to emit fluorescent signals and to blink in response to rotating magnetic fields. Separating the blinking probe signal from the unmodulated background signal allows for simple and sensitive detection of low analyte concentrations in the presence of autofluoresence.