In vitro and in vivo bacterial antifouling properties of phosphite plasma-treated silicone
Source abstract
Abstract
In order to improve their bacterial antifouling property, silicone surfaces were functionalized through the plasma polymerization (PP) technique using diethyl phosphite as the precursor. The functionalized surfaces were characterized using contact angle measurements, contact angle titration, Fourier transform infrared–attenuated total reflection spectroscopy and in vitro cytotoxicity assay. The amount of non-specific protein adsorption and the conformational changes of surface-adsorbed proteins were investigated. Antifouling properties of the surfaces were evaluated in vitro and in vivo. PP functionalization generated a hydrophilic and amphoteric surface with a very good protein and bacterial antifouling property and caused less conformational changes on the secondary structure of surface-adsorbed proteins. In in vivo conditions, no slime layer was formed around bacteria that adhered on the PP-functionalized surface. It is concluded that the amphoteric nature of the PP-functionalized surface is the reason for the good antifouling property.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Polymer Surface Interaction Studies · Marine Biology and Environmental Chemistry · Microplastics and Plastic Pollution
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Plasma Aided Bioengineering and Biotechnology Research Group, Institute for Pure and Applied Sciences, Hacettepe University, Ankara, Turkey
Nanotechnology and Nanomedicine Division, Hacettepe University, Ankara, Turkey
Department of Tourism and Hotel Management, Faculty of Business Administration, Atilim University, Ankara, Turkey
Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey
Department of Clinical Microbiology and Infectious Disease, Baskent University Faculty of Medicine, Ankara, Turkey
Department of Neurosurgery, Baskent University Faculty of Medicine, Ankara, Turkey
Bioengineering Division, Institute for Pure and Applied Sciences, Hacettepe University, Ankara, Turkey
Plasma Aided Biomedical Research Group, Department of Biomedical Engineering, Faculty of Engineering, TOBB University of Economics and Technology, Ankara, Turkey
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