Enhanced tissue-compatibility of polyethylenterephtalat membranes by plasma aminofunctionalisation

Abstract Polyethylenterephtalat track-etched membranes were plasma-modified to increase cell-adhesion and tissue-compatibility. Amine functionalities were grafted onto the surfaces by means of ammonia-plasma treatment, and plasma deposition of allylamine. Changes of chemical and physical properties of the samples were followed and in vitro evaluation of biocompatibility was carried out by studying human skin fibroblast interaction with surfaces. We found that fibroblasts adhered and grew better on poly-allylamine coated surfaces with higher amine concentration than on ammonia-plasma treated ones, but both had better cell-adhesive properties than the original membrane.