DataVXJournal of Laser ApplicationsPaper
journal article·2011-08-01

Parameter optimization of a laser-induced fluorescence system for in vivo screening of oral cancer

V. K. Unnikrishnan, Rajesh Nayak, Rodney Bernard, K. Jeena Priya, Ajeetkumar Patil, J. Ebenezer, Keerthilatha M. Pai, Sajan D. George, V. B. Kartha, C. Santhosh

Journal of Laser Applications· Volume 23· Issue 3
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Source abstract

Abstract

Despite the advances in optical technologies for early detection of cancer, routine clinical applications are still not standardized. Among several optical methods, laser-induced fluorescence is a more matured and well understood technique. Still due care has to be taken about various factors to avoid erroneous results. The authors have carried out a systematic study on the effect of the various experimental parameters such as source stability, area of exposure, and angular/distance dependence of a fiber probe, which is used for the fluorescence measurements, from the specimen surface on the spectra. Investigations are carried out on both idealistic cases as well as on tissue surface. The details of the optimization of the parameters are presented and discussed in this paper.
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Research context

OpenAlex topics: Photodynamic Therapy Research Studies · Photoacoustic and Ultrasonic Imaging · Laser Applications in Dentistry and Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Manipal University Centre for Atomic and Molecular Physics, , Manipal, 576 104, India

Manipal University Department of Oral Medicine and Radiology, MCODS Mangalore, , Manipal, 575 001, India

Manipal University Centre for Atomic and Molecular Physics, , Manipal, 576 104 India

Jamal Mohamed College PG & Research Department of Physics, , Tiruchinapalli, Manipal, 620 020, India

MCODS Manipal Department of Oral Medicine and Radiology, , Manipal University, Manipal,576 104 India

TU Darmstadt Center of Smart Interfaces, , Petersensstrasse 32, Darmstadt, 64287, Germany

21 Udayagiri, Sion, Trombay Road, Mumbai, 400 088, India

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