Development of a Multi-axial Mechanical Cell Stimulator
Source abstract
Abstract
This article proposes a novel electro-mechanical device to facilitate the investigation of mechanical stimuli on cells. The system was designed to dynamically apply a generalized, multi-axial state of deformation to a cell-encapsulated in a hydrogel cube by applying independent combinations of normal and shear forces to the faces of the cube. The compact device was prototyped using ABS plastic and used shape memory alloy actuator wires to generate the required forces and deformations. The electro-thermal and thermo-mechanical behaviors of the actuation system were modeled analytically and the stimulator was tested to evaluate its performance. Strain amplitudes of up to 8% (tension/compression and shear) were achievable, while deforming a cube with 1 cm side length.
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Research context
OpenAlex topics: Neuroscience and Neural Engineering · 3D Printing in Biomedical Research · Cellular Mechanics and Interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical and Materials Engineering, Queen's University, Kingston Ontario K7L 3N6, Canada
Department of Mechanical and Materials Engineering, Queen's University, Kingston Ontario K7L 3N6, Canada, Department of Chemical Engineering, Queen's University, Kingston Ontario K7L 3N6, Canada, Human Mobility Research Centre, Queen's University and Kingston General Hospital, Kingston Ontario K7L 2V7, Canada
Department of Mechanical and Materials Engineering, Queen's University, Kingston Ontario K7L 3N6, Canada,
References (15)
Show source-provided references
1. 10.1108/1355254021044116610.1108/13552540210441166 ↗
2. 10.1016/S0142-9612(00)00350-110.1016/S0142-9612(00)00350-1 ↗
3. Bo, Z. · Analysis and Applications · 1994 · 45 · 9
4. 10.1177/1045389X940050030610.1177/1045389X9400500306 ↗
5. 10.1177/1045389X960070011210.1177/1045389X9600700112 ↗
6. 10.1177/1045389X970080010310.1177/1045389X9700800103 ↗
7. 10.1016/S0021-9290(99)00177-310.1016/S0021-9290(99)00177-3 ↗
8. 10.1016/S0021-9290(00)00100-710.1016/S0021-9290(00)00100-7 ↗
9. 10.1023/B:ABME.0000007789.99565.4210.1023/B:ABME.0000007789.99565.42 ↗
10. 10.1115/1.158249910.1115/1.1582499 ↗
11. 10.1007/s00249-007-0139-110.1007/s00249-007-0139-1 ↗
12. 10.1088/0964-1726/6/3/00510.1088/0964-1726/6/3/005 ↗
13. 10.1089/107632704250021010.1089/1076327042500210 ↗
14. 10.22203/eCM.v013a0710.22203/eCM.v013a07 ↗
15. Wartella, K.A.