DataVXJournal of Intelligent Material Systems and StructuresPaper
journal article·1994-05

A Self-Regulated Insulin Delivery System Using Boronic Acid Gel

Daijiro Shiino, Kazunori Kataoka, Yoshiyuki Koyama, Masayuki Yokoyama, Teruo Okano, Yasuhisa Sakurai

Journal of Intelligent Material Systems and Structures· Volume 5· Issue 3
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Source abstract

Abstract

A novel polymer system sensitive to glucose concentration has been studied as a can didate material for chemically regulated insulin release system. Phenylboronic acid is able to form reversible binding to cis-diol substances. A glucose responsive insulin release system has been studied with utilization of phenylboronic acid polymers for the key material in the exchange reaction between gluconic acid modified insulin (G-Ins) and glucose. The released concentration of G-Ins from the polymer was pulsatile in response to the repeated stepwise concentration changes of glu cose. The linearity between glucose concentration and peak height of released G-Ins and the release response demonstrated no lag time to changes in glucose concentration were other important finites. The phenylboronic acid polymer shows considerable promise for use in a self-regulating insulin delivery system.
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Research context

Polymers

OpenAlex topics: Carbohydrate Chemistry and Synthesis · Glycosylation and Glycoproteins Research · Pancreatic function and diabetes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, NOF Corporation Tsukuba Research Laboratory Tokodai 5-10 Tsukuba-shi, Ibaraki 300-26 Japan

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Department of Materials Science and Research Institute for Biosciences Science University of Tokyo Yamazaki 2641 Noda-shi, Chiba 278 Japan

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Research Institute for Biosciences Science University of Tokyo Yamazaki 2669-1 Noda-shi, Chiba 278 Japan

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Institute of Biomedical Engineering Tokyo Women's Medical College Kawada-cho 8-1 Shinjuku-ku, Tokyo 162 Japan

References (15)

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