Study on Hemostatic Materials of Mesoporous Silicon Dioxide Doped Ca and Ag with Antibacterial Properties

An antibacterial hemostatic material of mesoporous silicon oxide gel doped with Ca and Ag(m-SCA) gel was fabricated by using cetyltrimethylammonium bromide(CTAB) as templates and Sol-Gel process.The results showed that m-SCA with mesoporous structure had the surface area of 416 m2/g and pore size of around 2 nm.The m-SCA with high surface area and good clotting function could significantly shorten the prothrombin time(PT) and activated partial thromboplastin time(APTT).The m-SCA containing a small quantity of Ag had no obvious effects on its clotting properties while Ca in m-SCA could promote clotting.The m-SCA doped 0.02wt% Ag without cytotoxicity had good antibacterial properties against E.coli.Animal experimental results showed that the m-SCA could control hemorrhage and shorten the bleeding time of rabbit ear wound,showing good hemostatic properties.It suggestes that the m-SCA is a good hemostatic material with antibacterial properties.