Microwave-assisted Solvothermal Synthesis of Calcium Phosphate Microspheres and Polyhedra

Synthetic calcium phosphate(CaP) has been investigated as promising biomaterial due to its excellent biocompatibility.CaP nanosheet-assembled microspheres were prepared using Ca(CH3COO)2,NaH2PO4·2H2O and PLA-mPEG in aqueous solution by microwave-assisted hydrothermal method at 120℃ for 30 min.Meanwhile,CaP polyhedral were prepared using Ca(CH3COO)2,NaH2PO4·2H2O and PLA-mPEG in mixed solvent of water and ethylene glycol(EG) by microwave-assisted solvothermal method at 120℃ for 30 min.The products were characterized with X-ray powder diffraction(XRD),transmission electron microscope(TEM),scanning electron microscope(SEM) and thermogravimetric analysis(TG).EG showed a significant effect on the chemical composition and morphology of the product.The hemoglobin protein adsorption properties of the as-prepared products were investigated.The Hb adsorption amount increased with increasing Hb initial concentration,and were decreased with increasing volume of EG.