Study on Hemostatic Materials of Mesoporous Silicon Dioxide Doped Ca and Ag with Antibacterial Properties

An antibacterial hemostatic material of mesoporous silicon oxide gel doped with Ca and Ag (m-SCA) gel was fabricated by using cetyltrimethylammonium bromide(CTAB) as templates and Sol-Gel process. The results showed that m-SCA with mesoporous structure had the surface area of 416 m 2 /g and pore size of around 2 nm. The m-SCA with high surface area and good clotting function could significantly shorten the prothrombin time (PT) and activated partial thromboplastin time (APTT). The m-SCA containing a small quantity of Ag had no obvious effects on its clotting properties while Ca in m-SCA could promote clotting. The m-SCA doped 0.02wt% Ag without cyto- toxicity had good antibacterial properties against E.coli. Animal experimental results showed that the m-SCA could control hemorrhage and shorten the bleeding time of rabbit ear wound, showing good hemostatic properties. It sug- gestes that the m-SCA is a good hemostatic material with antibacterial properties.