Preparation and Characterization of Magnetic Nornoxacin Gelatin Microspheres

Based on the biological compatibility of gelatin in water and its solidification by glu-taradehyde, the magnetic norfloxacin gelatin core-shell microspheres were prepared by means of the reverse phase suspension cold-condensation method using FesO4 as core and glutaric dialde-hycle as dispersed medium. The products were characterized by IR, SEM, TEM, UV/Vis. The results show that the microspheres are spherical in shape with smooth surfaces. The diameter of the microspheres is in the rang from 5 to 10μm, The content of drug in microspheres is 6.2% and of Fe3O4 is 19%. The drug encapsulation efficiency is 61.4%, the quantity of drug released from microspheres in 5 hours is 74.4%. The microspheres have good properties of drug sustain releasing.