TiO2 Thin Film Deposited by Enhanced Ion Beam Technique to Improve Anti-coagulability of Pyrolysis Carbon Applied to Artificial Heart Valves

A new kind of materials applied to the artificial heart valve, rutile-TiO2 thin film on low temperature isotropic pyrolysis carbon (LTI-carbon) was deposited through the enhanced ion beam approach. The thrombosis on the surface of samples was observed through platelet adhesion in vitro and animal experiments in vivo, respectively. Compared with LTI-carbon material, there is much less platelets adhesion, aggretated and coagulated as well as deformed on the surface of the thin film. Animal experiments in vivo also show that the amount of thrombus on the observed surface is much less than that of LTI-carbon. There are numerous platelets and fibrin aggregated and formed on the surface of LTI-carbon, but not on the surface of the thin film. The anti-coagulability of the deposited rutile-Ti02 thin film is much better than that of LTI-carbon traditionally used in artificial heart valves. And it also indicates that the deposited TiO2 thin film is a new kind of promising materials applied to artificial heart valves.