Preparation and in vitro Properties of CaSiO_3/TiO_2 Composite Bioceramics

CaSiO3 has attracted much attention as a bone substitute due to its strong ability to induce the formation of bonelike apatite in vitro.However,its poor chemical stability,biocompatibility,sintering and mechanical properties limit its further applications.In the present study,CaSiO3/TiO2 composites with initial CaSiO3/TiO2molar ratios at 2:1,3:1 and 5:1 were prepared by solid-state reaction method.CaSiO3/TiO2 ceramics sintered at 1100℃ with the crystal phases of CaSiO3 and CaTiSiO5were found to have optimistic sintering behavior,mechanical properties and degradability compared with pure CaSiO3 ceramics.With the CaSiO3content increased,the mechanical properties were enhanced while the in vitro bioactivity and biodegradability decreased.All these results suggest that CaSiO3/TiO2 composite ceramics maybe a prospective candidate for bone repair and the properties can be adjusted by changing their chemical compositions to adapt to bone regeneration.