Bone-like Apatite Formation on Calcium Phosphate Dense Ceramicsin Dynamic SBF

Bone-like apatite formation on the surface of calcium phosphate ceramics has been believed to be the necessary step that new bone grows on the ceramics and to be relative to the osteoinductivity of the material. The research of the factors effecting bone-like apatite formation is a great help to understanding the mechanism of osteoinduction. This study was a comparative study of in vitro formation of bone-like apatite on the surface of dense calcium phosphate ceramics with SBF flowing at different speeds. The results showed that the rough surface was beneficial to the formation of bone-like apatite and the apatite formed faster in 1.5 SBF than in SBF. Rough surface, namely, larger surface area, increased the dissolution of Ca2+, HPO42- and higher concentration of Ca2+ and HPO42- ions of SBF was advantageous to the accumulation of Ca2+, HPO42-, PO43- near the ceramic surface. Local supersaturating concentration of Ca2+, HP042-. PO43- near sample surface was critical for nucleation of apatite on the surface of sample.