Preparation and Characterization of Bioactive Poly (Lactic Acid)/SiO_2-CaO Composite Membranes

A novel porous poly(lactic acid)(PLA)/SiO2-CaO(n(SiO2):n(CaO)=1:1) composite membrane is synthe-sized by Sol-Gel method.The microstructure and composition of the composite membranes are characterized by Fou-rier transform infrared(FTIR) spectroscope and scanning electron microscope(SEM).The surface zeta potential is monitored by the SurPASS electrokinetic analyzer.The bioactivity is evaluated by investigating the formation of apa-tite on the surface of the composite membranes in simulated body fluids and the cytotoxicity is evaluated by MTT ex-periments.After soaked in simulated body fluids for 7d,the surface of the PLA/SiO2-CaO composite membranes is covered by an apatite layer with an orderly ring structure.The surface zeta potential of the composite membranes de-creases with increasing SiO2-CaO contents suggesting better bioactivity.The PLA/SiO2-CaO composite membranes do not induce cytotoxcity to MG-63 cells and support cell proliferation.